Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis
The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in...
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| Veröffentlicht in: | Experimental parasitology 2021-01, Vol.220, p.108042-108042, Article 108042 |
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| creator | Shirgholami, Z. Borji, H. Mohebalian, H. Heidarpour, M. |
| description | The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in this study. Each animal was intraperitoneally injected with 1500 protoscoleces. The infected animals were randomly divided into six groups: albendazole (100 mg/kg), MEAS 10 (10 mg/kg), MEAS 20 (20 mg/kg), MEAS 40 (40 mg/kg), MEAS 80 (80 mg/kg) and control group with no treatment. The studied animals received albendazole and/or MEAS through drinking water for 30 days. Serum IFN-γ concentration significantly increased in the MEAS 20 and 80 groups in comparison to the control, albendazole and MEAS 10 groups (P |
| doi_str_mv | 10.1016/j.exppara.2020.108042 |
| format | Article |
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[Display omitted]
•A significant increase in IFN-γ concentration was observed in MEAS 20 and 80 groups.•Present study showed that MEAS can enhance Th1 response in mice with echinococcosis.•It may have therapeutic value in medical therapy of cystic echinococcosis.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/j.exppara.2020.108042</identifier><identifier>PMID: 33207240</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Albendazole - administration & dosage ; Albendazole - pharmacology ; Albendazole - therapeutic use ; Allium sativum ; Animals ; Anticestodal Agents - administration & dosage ; Anticestodal Agents - pharmacology ; Anticestodal Agents - therapeutic use ; Cystic echinococcosis ; Drinking Water - chemistry ; Echinococcosis - drug therapy ; Echinococcosis - immunology ; Echinococcus granulosus - drug effects ; Echinococcus granulosus - immunology ; Female ; Garlic - chemistry ; IFN-γ ; IL4 ; Interferon-gamma - blood ; Interleukin-4 - blood ; Mice ; Mice, Inbred BALB C ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Random Allocation</subject><ispartof>Experimental parasitology, 2021-01, Vol.220, p.108042-108042, Article 108042</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-55e304394171ef8a30a7671bc63490380c0e8093e1d95224e7dee400e8fb88713</citedby><cites>FETCH-LOGICAL-c365t-55e304394171ef8a30a7671bc63490380c0e8093e1d95224e7dee400e8fb88713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exppara.2020.108042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33207240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shirgholami, Z.</creatorcontrib><creatorcontrib>Borji, H.</creatorcontrib><creatorcontrib>Mohebalian, H.</creatorcontrib><creatorcontrib>Heidarpour, M.</creatorcontrib><title>Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in this study. Each animal was intraperitoneally injected with 1500 protoscoleces. The infected animals were randomly divided into six groups: albendazole (100 mg/kg), MEAS 10 (10 mg/kg), MEAS 20 (20 mg/kg), MEAS 40 (40 mg/kg), MEAS 80 (80 mg/kg) and control group with no treatment. The studied animals received albendazole and/or MEAS through drinking water for 30 days. Serum IFN-γ concentration significantly increased in the MEAS 20 and 80 groups in comparison to the control, albendazole and MEAS 10 groups (P < 0.05). The serum IL-4 level showed no significant difference between the trial groups. The findings of this study showed that MEAS at 20 and 80 mg/kg concentrations enhanced Th1 cell response in mice with cystic echinococcosis.
[Display omitted]
•A significant increase in IFN-γ concentration was observed in MEAS 20 and 80 groups.•Present study showed that MEAS can enhance Th1 response in mice with echinococcosis.•It may have therapeutic value in medical therapy of cystic echinococcosis.</description><subject>Administration, Oral</subject><subject>Albendazole - administration & dosage</subject><subject>Albendazole - pharmacology</subject><subject>Albendazole - therapeutic use</subject><subject>Allium sativum</subject><subject>Animals</subject><subject>Anticestodal Agents - administration & dosage</subject><subject>Anticestodal Agents - pharmacology</subject><subject>Anticestodal Agents - therapeutic use</subject><subject>Cystic echinococcosis</subject><subject>Drinking Water - chemistry</subject><subject>Echinococcosis - drug therapy</subject><subject>Echinococcosis - immunology</subject><subject>Echinococcus granulosus - drug effects</subject><subject>Echinococcus granulosus - immunology</subject><subject>Female</subject><subject>Garlic - chemistry</subject><subject>IFN-γ</subject><subject>IL4</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-4 - blood</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Random Allocation</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1u2zAQRomiReMkPUILLruROyRHErUKgiA_BoxkkywDgqZGCA1JdEg5bc6Ve-RMpWG326w-YPBmPsxj7LuAuQBR_VrP6c9mY6OdS5C7mQaUn9hMQAOFRGw-sxmAwAJ1g0fsOKU1AGgh8Ss7UkpCLRFm7PGy68hNiYeOn_e93w482cm_5AwjX1zdFu9v3I4tXyyRuzA6GqeYgTAm7kc-eEf8t5-euHtNk3ec3JMfgwvOheTTKfvS2T7Rt0OesIery_uLm2J5d724OF8WTlXlVJQlKUDVoKgFddoqsHVVi5WrFDagNDggDY0i0TallEh1S4SQh91K61qoE_Zzf3cTw_OW0mQGnxz1vR0pbJORWOVvNSJmtNyjLoaUInVmE_1g46sRYHZmzdoczJqdWbM3m_d-HCq2q4Ha_1v_VGbgbA9QfvTFUzTJecrCWh-zYdMG_0HFX5Jdi30</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Shirgholami, Z.</creator><creator>Borji, H.</creator><creator>Mohebalian, H.</creator><creator>Heidarpour, M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202101</creationdate><title>Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis</title><author>Shirgholami, Z. ; Borji, H. ; Mohebalian, H. ; Heidarpour, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-55e304394171ef8a30a7671bc63490380c0e8093e1d95224e7dee400e8fb88713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Administration, Oral</topic><topic>Albendazole - administration & dosage</topic><topic>Albendazole - pharmacology</topic><topic>Albendazole - therapeutic use</topic><topic>Allium sativum</topic><topic>Animals</topic><topic>Anticestodal Agents - administration & dosage</topic><topic>Anticestodal Agents - pharmacology</topic><topic>Anticestodal Agents - therapeutic use</topic><topic>Cystic echinococcosis</topic><topic>Drinking Water - chemistry</topic><topic>Echinococcosis - drug therapy</topic><topic>Echinococcosis - immunology</topic><topic>Echinococcus granulosus - drug effects</topic><topic>Echinococcus granulosus - immunology</topic><topic>Female</topic><topic>Garlic - chemistry</topic><topic>IFN-γ</topic><topic>IL4</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-4 - blood</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shirgholami, Z.</creatorcontrib><creatorcontrib>Borji, H.</creatorcontrib><creatorcontrib>Mohebalian, H.</creatorcontrib><creatorcontrib>Heidarpour, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shirgholami, Z.</au><au>Borji, H.</au><au>Mohebalian, H.</au><au>Heidarpour, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis</atitle><jtitle>Experimental parasitology</jtitle><addtitle>Exp Parasitol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>220</volume><spage>108042</spage><epage>108042</epage><pages>108042-108042</pages><artnum>108042</artnum><issn>0014-4894</issn><eissn>1090-2449</eissn><abstract>The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in this study. Each animal was intraperitoneally injected with 1500 protoscoleces. The infected animals were randomly divided into six groups: albendazole (100 mg/kg), MEAS 10 (10 mg/kg), MEAS 20 (20 mg/kg), MEAS 40 (40 mg/kg), MEAS 80 (80 mg/kg) and control group with no treatment. The studied animals received albendazole and/or MEAS through drinking water for 30 days. Serum IFN-γ concentration significantly increased in the MEAS 20 and 80 groups in comparison to the control, albendazole and MEAS 10 groups (P < 0.05). The serum IL-4 level showed no significant difference between the trial groups. The findings of this study showed that MEAS at 20 and 80 mg/kg concentrations enhanced Th1 cell response in mice with cystic echinococcosis.
[Display omitted]
•A significant increase in IFN-γ concentration was observed in MEAS 20 and 80 groups.•Present study showed that MEAS can enhance Th1 response in mice with echinococcosis.•It may have therapeutic value in medical therapy of cystic echinococcosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33207240</pmid><doi>10.1016/j.exppara.2020.108042</doi><tpages>1</tpages></addata></record> |
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| subjects | Administration, Oral Albendazole - administration & dosage Albendazole - pharmacology Albendazole - therapeutic use Allium sativum Animals Anticestodal Agents - administration & dosage Anticestodal Agents - pharmacology Anticestodal Agents - therapeutic use Cystic echinococcosis Drinking Water - chemistry Echinococcosis - drug therapy Echinococcosis - immunology Echinococcus granulosus - drug effects Echinococcus granulosus - immunology Female Garlic - chemistry IFN-γ IL4 Interferon-gamma - blood Interleukin-4 - blood Mice Mice, Inbred BALB C Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Random Allocation |
| title | Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis |
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