Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats
It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field te...
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| Veröffentlicht in: | Phytotherapy research 2021-04, Vol.35 (4), p.2074-2084 |
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| creator | Sakhri, Fatma Z. Adachi, Naoki Zerizer, Sakina Ohashi, Yusuke Ikemoto, Hideshi Tsukada, Mana Kabouche, Zahia Hisamitsu, Tadashi Sunagawa, Masataka |
| description | It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) and on neurological alterations by analysis of the hippocampal neurogenesis. A daily 6 hr exposure to chronic immobilization stress (CIS) for 21 consecutive days induced anxiety‐ and depressive‐like behaviors in rats' concomitant with decreased weight gain and increased plasma corticosterone (CORT) levels, rats also showed atrophy in the CA3 subregion of the hippocampus and a decreased number of Ki67 and DCX positive cells in the dentate gyrus (DG). Treatment with HECO successfully suppressed the physiological and behavioral markers of the CIS and prevents the structural abnormality and the impaired cell proliferation in the hippocampus. Moreover, the daily administration of HECO improved the mood function in normal rats. Taking together, our findings demonstrate, for the first time, the anti‐depressive effect of C. oblonga fruit by enhancing the hippocampal neurogenesis in the rat model of depression. |
| doi_str_mv | 10.1002/ptr.6953 |
| format | Article |
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In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) and on neurological alterations by analysis of the hippocampal neurogenesis. A daily 6 hr exposure to chronic immobilization stress (CIS) for 21 consecutive days induced anxiety‐ and depressive‐like behaviors in rats' concomitant with decreased weight gain and increased plasma corticosterone (CORT) levels, rats also showed atrophy in the CA3 subregion of the hippocampus and a decreased number of Ki67 and DCX positive cells in the dentate gyrus (DG). Treatment with HECO successfully suppressed the physiological and behavioral markers of the CIS and prevents the structural abnormality and the impaired cell proliferation in the hippocampus. Moreover, the daily administration of HECO improved the mood function in normal rats. Taking together, our findings demonstrate, for the first time, the anti‐depressive effect of C. oblonga fruit by enhancing the hippocampal neurogenesis in the rat model of depression.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.6953</identifier><identifier>PMID: 33205508</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Atrophy ; Cell proliferation ; Chronic Disease ; chronic immobilization stress ; Corticosterone ; Cydonia oblonga ; Dentate gyrus ; depression ; Doublecortin protein ; Field tests ; Fruit - chemistry ; Fruits ; hippocampal neurogenesis ; Hippocampus ; Immobilization ; Male ; Mental disorders ; Mood ; Neurogenesis ; Open-field behavior ; Physiology ; Plant Extracts - chemistry ; Rats ; Rats, Wistar ; Rosaceae - chemistry ; Stress ; Stress, Physiological - drug effects ; Sucrose</subject><ispartof>Phytotherapy research, 2021-04, Vol.35 (4), p.2074-2084</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4153-ecc082e344814dbc1f548b1999b791cbc381295095726d44f4572c1803cf0f593</citedby><cites>FETCH-LOGICAL-c4153-ecc082e344814dbc1f548b1999b791cbc381295095726d44f4572c1803cf0f593</cites><orcidid>0000-0002-4850-1467</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.6953$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.6953$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33205508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakhri, Fatma Z.</creatorcontrib><creatorcontrib>Adachi, Naoki</creatorcontrib><creatorcontrib>Zerizer, Sakina</creatorcontrib><creatorcontrib>Ohashi, Yusuke</creatorcontrib><creatorcontrib>Ikemoto, Hideshi</creatorcontrib><creatorcontrib>Tsukada, Mana</creatorcontrib><creatorcontrib>Kabouche, Zahia</creatorcontrib><creatorcontrib>Hisamitsu, Tadashi</creatorcontrib><creatorcontrib>Sunagawa, Masataka</creatorcontrib><title>Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) and on neurological alterations by analysis of the hippocampal neurogenesis. A daily 6 hr exposure to chronic immobilization stress (CIS) for 21 consecutive days induced anxiety‐ and depressive‐like behaviors in rats' concomitant with decreased weight gain and increased plasma corticosterone (CORT) levels, rats also showed atrophy in the CA3 subregion of the hippocampus and a decreased number of Ki67 and DCX positive cells in the dentate gyrus (DG). Treatment with HECO successfully suppressed the physiological and behavioral markers of the CIS and prevents the structural abnormality and the impaired cell proliferation in the hippocampus. Moreover, the daily administration of HECO improved the mood function in normal rats. Taking together, our findings demonstrate, for the first time, the anti‐depressive effect of C. oblonga fruit by enhancing the hippocampal neurogenesis in the rat model of depression.</description><subject>Animals</subject><subject>Atrophy</subject><subject>Cell proliferation</subject><subject>Chronic Disease</subject><subject>chronic immobilization stress</subject><subject>Corticosterone</subject><subject>Cydonia oblonga</subject><subject>Dentate gyrus</subject><subject>depression</subject><subject>Doublecortin protein</subject><subject>Field tests</subject><subject>Fruit - chemistry</subject><subject>Fruits</subject><subject>hippocampal neurogenesis</subject><subject>Hippocampus</subject><subject>Immobilization</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Mood</subject><subject>Neurogenesis</subject><subject>Open-field behavior</subject><subject>Physiology</subject><subject>Plant Extracts - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rosaceae - chemistry</subject><subject>Stress</subject><subject>Stress, Physiological - drug effects</subject><subject>Sucrose</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1rGzEQhkVJaJy00F9QBLn0ss5oJa1Xx9bkCwIpxYXehFardRR2JUfSOnV_feTYTSCQkwbxzKMZvQh9ITAlAOXZKoVpJTj9gCYEhCgIn9EDNAHBScFI_ecIHcd4DwCiBPYRHVFaAudQT5D7Ye7U2vqgeqxci50Zg-_90up8YYdV8GszGJdws8HzTeudVdg3vXdLhbsw2oTN3xSUTtg6rO9CBnTuG3xje_tPJesdjimYGHFQKX5Ch53qo_m8P0_Q74vzxfyquLm9vJ5_vyk0I5wWRmuoS0MZqwlrG006zuqGCCGamSC60bQmpeB5v1lZtYx1LBea1EB1Bx0X9AR923nzAg-jiUkONmrT98oZP0ZZsorUVfZDRk_foPd-DC5PJ0tOID8MFX0V6uBjDKaTq2AHFTaSgNxmIHMGcptBRr_uhWMzmPYF_P_pGSh2wKPtzeZdkfy5-PUsfAL8X5Cy</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Sakhri, Fatma Z.</creator><creator>Adachi, Naoki</creator><creator>Zerizer, Sakina</creator><creator>Ohashi, Yusuke</creator><creator>Ikemoto, Hideshi</creator><creator>Tsukada, Mana</creator><creator>Kabouche, Zahia</creator><creator>Hisamitsu, Tadashi</creator><creator>Sunagawa, Masataka</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4850-1467</orcidid></search><sort><creationdate>202104</creationdate><title>Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats</title><author>Sakhri, Fatma Z. ; Adachi, Naoki ; Zerizer, Sakina ; Ohashi, Yusuke ; Ikemoto, Hideshi ; Tsukada, Mana ; Kabouche, Zahia ; Hisamitsu, Tadashi ; Sunagawa, Masataka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4153-ecc082e344814dbc1f548b1999b791cbc381295095726d44f4572c1803cf0f593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Atrophy</topic><topic>Cell proliferation</topic><topic>Chronic Disease</topic><topic>chronic immobilization stress</topic><topic>Corticosterone</topic><topic>Cydonia oblonga</topic><topic>Dentate gyrus</topic><topic>depression</topic><topic>Doublecortin protein</topic><topic>Field tests</topic><topic>Fruit - chemistry</topic><topic>Fruits</topic><topic>hippocampal neurogenesis</topic><topic>Hippocampus</topic><topic>Immobilization</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Mood</topic><topic>Neurogenesis</topic><topic>Open-field behavior</topic><topic>Physiology</topic><topic>Plant Extracts - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rosaceae - chemistry</topic><topic>Stress</topic><topic>Stress, Physiological - drug effects</topic><topic>Sucrose</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakhri, Fatma Z.</creatorcontrib><creatorcontrib>Adachi, Naoki</creatorcontrib><creatorcontrib>Zerizer, Sakina</creatorcontrib><creatorcontrib>Ohashi, Yusuke</creatorcontrib><creatorcontrib>Ikemoto, Hideshi</creatorcontrib><creatorcontrib>Tsukada, Mana</creatorcontrib><creatorcontrib>Kabouche, Zahia</creatorcontrib><creatorcontrib>Hisamitsu, Tadashi</creatorcontrib><creatorcontrib>Sunagawa, Masataka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakhri, Fatma Z.</au><au>Adachi, Naoki</au><au>Zerizer, Sakina</au><au>Ohashi, Yusuke</au><au>Ikemoto, Hideshi</au><au>Tsukada, Mana</au><au>Kabouche, Zahia</au><au>Hisamitsu, Tadashi</au><au>Sunagawa, Masataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2021-04</date><risdate>2021</risdate><volume>35</volume><issue>4</issue><spage>2074</spage><epage>2084</epage><pages>2074-2084</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) and on neurological alterations by analysis of the hippocampal neurogenesis. A daily 6 hr exposure to chronic immobilization stress (CIS) for 21 consecutive days induced anxiety‐ and depressive‐like behaviors in rats' concomitant with decreased weight gain and increased plasma corticosterone (CORT) levels, rats also showed atrophy in the CA3 subregion of the hippocampus and a decreased number of Ki67 and DCX positive cells in the dentate gyrus (DG). Treatment with HECO successfully suppressed the physiological and behavioral markers of the CIS and prevents the structural abnormality and the impaired cell proliferation in the hippocampus. Moreover, the daily administration of HECO improved the mood function in normal rats. Taking together, our findings demonstrate, for the first time, the anti‐depressive effect of C. oblonga fruit by enhancing the hippocampal neurogenesis in the rat model of depression.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>33205508</pmid><doi>10.1002/ptr.6953</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4850-1467</orcidid></addata></record> |
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| subjects | Animals Atrophy Cell proliferation Chronic Disease chronic immobilization stress Corticosterone Cydonia oblonga Dentate gyrus depression Doublecortin protein Field tests Fruit - chemistry Fruits hippocampal neurogenesis Hippocampus Immobilization Male Mental disorders Mood Neurogenesis Open-field behavior Physiology Plant Extracts - chemistry Rats Rats, Wistar Rosaceae - chemistry Stress Stress, Physiological - drug effects Sucrose |
| title | Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats |
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