Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease
Background Protein energy wasting (PEW) is a common cause of morbidity and mortality in patients with stage 5 chronic kidney disease (CKD 5). Intradialytic parenteral nutrition (IDPN) has been used as a therapy for preventing and treating PEW in children with CKD 5 when other conventional modalities...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2021-06, Vol.36 (6), p.1561-1569 |
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| creator | El-Serw, Hagar El-Saied Saad Bassiouni, Dina Abdel Rasoul Helal Al-Wakeil, Angy Adel El-Masry, Ragaa Shawky Aly Ibrahim Bakr, Ashraf Mohamed Abd EI Basset |
| description | Background
Protein energy wasting (PEW) is a common cause of morbidity and mortality in patients with stage 5 chronic kidney disease (CKD 5). Intradialytic parenteral nutrition (IDPN) has been used as a therapy for preventing and treating PEW in children with CKD 5 when other conventional modalities fail. However, not enough data is available to define its effectiveness in treating malnutrition in children. This study aims to investigate potential benefits of IDPN in Egyptian children with CKD 5.
Methods
In this prospective, placebo-controlled, parallel-group single blinded study, we enrolled 50 CKD 5 patients; 25 patients (intervention group) received intravenous amino acids (KIDIMN), while 25 patients (control group) received normal saline as placebo, each given during regular dialysis 3 times a week for 9 months. Patients were subjected to nutritional assessment at baseline and 3-, 6-, and 9-month follow-up using height Z-score, hand grip strength (HGS) for muscle power assessment, body composition monitor (BCM) for assessing lean tissue mass (LTM) and adipose tissue mass (ATM), and biochemical measures including serum albumin, serum triglyceride, and serum cholesterol.
Results
When comparing baseline and 9-month follow-up values, significant improvement was recorded in height Z-score, LTM, and serum albumin in the intervention group unlike the control group where no significant changes were recorded.
Conclusion
IDPN is proposed to be an effective method for preventing and treating malnutrition in children with CKD 5. However, further multi-centric studies with larger sample size and longer duration of follow-up are still recommended. |
| doi_str_mv | 10.1007/s00467-020-04806-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2461863080</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A660213904</galeid><sourcerecordid>A660213904</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-68ba3dc99b199df3e9459c13643ee92392fb70ede8b2af5f365b3d33856b8ddf3</originalsourceid><addsrcrecordid>eNp9kk1rVDEYhS-i2LH6B1xIQBA3t-bj3kyyLKV-QMGNQnchN3kzkzaT1CQXO__eTKdaK4NkEXjf5xzIyem61wSfEIyXHwrGA1_2mOIeDwLz_vZJtyADoz2R4vJpt8CSkbYil0fdi1KuMMZiFPx5d8QYxZxSseiuz53zRpstSg75WLO2Xodt9QbpjY8JaeNtQSmiONfsq09RB1SqrnNpPDJrH2yGiH76ut7NV4DGNs0pNotrbyNskfUFdIGX3TOnQ4FX9_dx9_3j-bezz_3F109fzk4vejMSUnsuJs2skXIiUlrHQA6jNITxgQFIyiR10xKDBTFR7UbH-Dgxy5gY-SRsExx37_e-Nzn9mKFUtfHFQAg6QpqLogMngjMscEPf_oNepTm3JzZqJHLksmX8QK10AOWjSy0nszNVp5xjSpi8o_oD1AoiZB1SBOfb-BF_coBvx8LGm4OCd38J1qBDXZcU5t2nlMcg3YMmp1IyOHWT_UbnrSJY7aqj9tVRrTrqrjrqtone3EcxTxuwfyS_u9IAtgdKW8UV5Ies_mP7C0tOzSs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2519569004</pqid></control><display><type>article</type><title>Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>El-Serw, Hagar El-Saied Saad ; Bassiouni, Dina Abdel Rasoul Helal ; Al-Wakeil, Angy Adel ; El-Masry, Ragaa Shawky Aly Ibrahim ; Bakr, Ashraf Mohamed Abd EI Basset</creator><creatorcontrib>El-Serw, Hagar El-Saied Saad ; Bassiouni, Dina Abdel Rasoul Helal ; Al-Wakeil, Angy Adel ; El-Masry, Ragaa Shawky Aly Ibrahim ; Bakr, Ashraf Mohamed Abd EI Basset</creatorcontrib><description>Background
Protein energy wasting (PEW) is a common cause of morbidity and mortality in patients with stage 5 chronic kidney disease (CKD 5). Intradialytic parenteral nutrition (IDPN) has been used as a therapy for preventing and treating PEW in children with CKD 5 when other conventional modalities fail. However, not enough data is available to define its effectiveness in treating malnutrition in children. This study aims to investigate potential benefits of IDPN in Egyptian children with CKD 5.
Methods
In this prospective, placebo-controlled, parallel-group single blinded study, we enrolled 50 CKD 5 patients; 25 patients (intervention group) received intravenous amino acids (KIDIMN), while 25 patients (control group) received normal saline as placebo, each given during regular dialysis 3 times a week for 9 months. Patients were subjected to nutritional assessment at baseline and 3-, 6-, and 9-month follow-up using height Z-score, hand grip strength (HGS) for muscle power assessment, body composition monitor (BCM) for assessing lean tissue mass (LTM) and adipose tissue mass (ATM), and biochemical measures including serum albumin, serum triglyceride, and serum cholesterol.
Results
When comparing baseline and 9-month follow-up values, significant improvement was recorded in height Z-score, LTM, and serum albumin in the intervention group unlike the control group where no significant changes were recorded.
Conclusion
IDPN is proposed to be an effective method for preventing and treating malnutrition in children with CKD 5. However, further multi-centric studies with larger sample size and longer duration of follow-up are still recommended.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-020-04806-x</identifier><identifier>PMID: 33206228</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adipose tissue ; Albumin ; Amino Acids ; Body composition ; Care and treatment ; Child ; Child Nutrition Disorders ; Children ; Cholesterol ; Chronic kidney failure ; Complications and side effects ; Dialysis ; Hand Strength ; Health aspects ; Humans ; Intravenous administration ; Kidney diseases ; Kidney Failure, Chronic ; Malnutrition ; Malnutrition - etiology ; Malnutrition - prevention & control ; Malnutrition in children ; Medicine ; Medicine & Public Health ; Methods ; Morbidity ; Nephrology ; Nutritional Status ; Original Article ; Parenteral feeding ; Parenteral nutrition ; Parenteral therapy ; Pediatric research ; Pediatrics ; Placebos ; Prospective Studies ; Protein-Energy Malnutrition ; Renal Dialysis - adverse effects ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - therapy ; Urology ; What’s New in Chronic Kidney Disease</subject><ispartof>Pediatric nephrology (Berlin, West), 2021-06, Vol.36 (6), p.1561-1569</ispartof><rights>IPNA 2020</rights><rights>COPYRIGHT 2021 Springer</rights><rights>IPNA 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-68ba3dc99b199df3e9459c13643ee92392fb70ede8b2af5f365b3d33856b8ddf3</citedby><cites>FETCH-LOGICAL-c511t-68ba3dc99b199df3e9459c13643ee92392fb70ede8b2af5f365b3d33856b8ddf3</cites><orcidid>0000-0002-3575-887X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-020-04806-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-020-04806-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33206228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Serw, Hagar El-Saied Saad</creatorcontrib><creatorcontrib>Bassiouni, Dina Abdel Rasoul Helal</creatorcontrib><creatorcontrib>Al-Wakeil, Angy Adel</creatorcontrib><creatorcontrib>El-Masry, Ragaa Shawky Aly Ibrahim</creatorcontrib><creatorcontrib>Bakr, Ashraf Mohamed Abd EI Basset</creatorcontrib><title>Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
Protein energy wasting (PEW) is a common cause of morbidity and mortality in patients with stage 5 chronic kidney disease (CKD 5). Intradialytic parenteral nutrition (IDPN) has been used as a therapy for preventing and treating PEW in children with CKD 5 when other conventional modalities fail. However, not enough data is available to define its effectiveness in treating malnutrition in children. This study aims to investigate potential benefits of IDPN in Egyptian children with CKD 5.
Methods
In this prospective, placebo-controlled, parallel-group single blinded study, we enrolled 50 CKD 5 patients; 25 patients (intervention group) received intravenous amino acids (KIDIMN), while 25 patients (control group) received normal saline as placebo, each given during regular dialysis 3 times a week for 9 months. Patients were subjected to nutritional assessment at baseline and 3-, 6-, and 9-month follow-up using height Z-score, hand grip strength (HGS) for muscle power assessment, body composition monitor (BCM) for assessing lean tissue mass (LTM) and adipose tissue mass (ATM), and biochemical measures including serum albumin, serum triglyceride, and serum cholesterol.
Results
When comparing baseline and 9-month follow-up values, significant improvement was recorded in height Z-score, LTM, and serum albumin in the intervention group unlike the control group where no significant changes were recorded.
Conclusion
IDPN is proposed to be an effective method for preventing and treating malnutrition in children with CKD 5. However, further multi-centric studies with larger sample size and longer duration of follow-up are still recommended.</description><subject>Adipose tissue</subject><subject>Albumin</subject><subject>Amino Acids</subject><subject>Body composition</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child Nutrition Disorders</subject><subject>Children</subject><subject>Cholesterol</subject><subject>Chronic kidney failure</subject><subject>Complications and side effects</subject><subject>Dialysis</subject><subject>Hand Strength</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intravenous administration</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic</subject><subject>Malnutrition</subject><subject>Malnutrition - etiology</subject><subject>Malnutrition - prevention & control</subject><subject>Malnutrition in children</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Morbidity</subject><subject>Nephrology</subject><subject>Nutritional Status</subject><subject>Original Article</subject><subject>Parenteral feeding</subject><subject>Parenteral nutrition</subject><subject>Parenteral therapy</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Placebos</subject><subject>Prospective Studies</subject><subject>Protein-Energy Malnutrition</subject><subject>Renal Dialysis - adverse effects</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Urology</subject><subject>What’s New in Chronic Kidney Disease</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kk1rVDEYhS-i2LH6B1xIQBA3t-bj3kyyLKV-QMGNQnchN3kzkzaT1CQXO__eTKdaK4NkEXjf5xzIyem61wSfEIyXHwrGA1_2mOIeDwLz_vZJtyADoz2R4vJpt8CSkbYil0fdi1KuMMZiFPx5d8QYxZxSseiuz53zRpstSg75WLO2Xodt9QbpjY8JaeNtQSmiONfsq09RB1SqrnNpPDJrH2yGiH76ut7NV4DGNs0pNotrbyNskfUFdIGX3TOnQ4FX9_dx9_3j-bezz_3F109fzk4vejMSUnsuJs2skXIiUlrHQA6jNITxgQFIyiR10xKDBTFR7UbH-Dgxy5gY-SRsExx37_e-Nzn9mKFUtfHFQAg6QpqLogMngjMscEPf_oNepTm3JzZqJHLksmX8QK10AOWjSy0nszNVp5xjSpi8o_oD1AoiZB1SBOfb-BF_coBvx8LGm4OCd38J1qBDXZcU5t2nlMcg3YMmp1IyOHWT_UbnrSJY7aqj9tVRrTrqrjrqtone3EcxTxuwfyS_u9IAtgdKW8UV5Ies_mP7C0tOzSs</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>El-Serw, Hagar El-Saied Saad</creator><creator>Bassiouni, Dina Abdel Rasoul Helal</creator><creator>Al-Wakeil, Angy Adel</creator><creator>El-Masry, Ragaa Shawky Aly Ibrahim</creator><creator>Bakr, Ashraf Mohamed Abd EI Basset</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3575-887X</orcidid></search><sort><creationdate>20210601</creationdate><title>Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease</title><author>El-Serw, Hagar El-Saied Saad ; Bassiouni, Dina Abdel Rasoul Helal ; Al-Wakeil, Angy Adel ; El-Masry, Ragaa Shawky Aly Ibrahim ; Bakr, Ashraf Mohamed Abd EI Basset</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-68ba3dc99b199df3e9459c13643ee92392fb70ede8b2af5f365b3d33856b8ddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Albumin</topic><topic>Amino Acids</topic><topic>Body composition</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child Nutrition Disorders</topic><topic>Children</topic><topic>Cholesterol</topic><topic>Chronic kidney failure</topic><topic>Complications and side effects</topic><topic>Dialysis</topic><topic>Hand Strength</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Intravenous administration</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic</topic><topic>Malnutrition</topic><topic>Malnutrition - etiology</topic><topic>Malnutrition - prevention & control</topic><topic>Malnutrition in children</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Morbidity</topic><topic>Nephrology</topic><topic>Nutritional Status</topic><topic>Original Article</topic><topic>Parenteral feeding</topic><topic>Parenteral nutrition</topic><topic>Parenteral therapy</topic><topic>Pediatric research</topic><topic>Pediatrics</topic><topic>Placebos</topic><topic>Prospective Studies</topic><topic>Protein-Energy Malnutrition</topic><topic>Renal Dialysis - adverse effects</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Urology</topic><topic>What’s New in Chronic Kidney Disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Serw, Hagar El-Saied Saad</creatorcontrib><creatorcontrib>Bassiouni, Dina Abdel Rasoul Helal</creatorcontrib><creatorcontrib>Al-Wakeil, Angy Adel</creatorcontrib><creatorcontrib>El-Masry, Ragaa Shawky Aly Ibrahim</creatorcontrib><creatorcontrib>Bakr, Ashraf Mohamed Abd EI Basset</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Serw, Hagar El-Saied Saad</au><au>Bassiouni, Dina Abdel Rasoul Helal</au><au>Al-Wakeil, Angy Adel</au><au>El-Masry, Ragaa Shawky Aly Ibrahim</au><au>Bakr, Ashraf Mohamed Abd EI Basset</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>36</volume><issue>6</issue><spage>1561</spage><epage>1569</epage><pages>1561-1569</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
Protein energy wasting (PEW) is a common cause of morbidity and mortality in patients with stage 5 chronic kidney disease (CKD 5). Intradialytic parenteral nutrition (IDPN) has been used as a therapy for preventing and treating PEW in children with CKD 5 when other conventional modalities fail. However, not enough data is available to define its effectiveness in treating malnutrition in children. This study aims to investigate potential benefits of IDPN in Egyptian children with CKD 5.
Methods
In this prospective, placebo-controlled, parallel-group single blinded study, we enrolled 50 CKD 5 patients; 25 patients (intervention group) received intravenous amino acids (KIDIMN), while 25 patients (control group) received normal saline as placebo, each given during regular dialysis 3 times a week for 9 months. Patients were subjected to nutritional assessment at baseline and 3-, 6-, and 9-month follow-up using height Z-score, hand grip strength (HGS) for muscle power assessment, body composition monitor (BCM) for assessing lean tissue mass (LTM) and adipose tissue mass (ATM), and biochemical measures including serum albumin, serum triglyceride, and serum cholesterol.
Results
When comparing baseline and 9-month follow-up values, significant improvement was recorded in height Z-score, LTM, and serum albumin in the intervention group unlike the control group where no significant changes were recorded.
Conclusion
IDPN is proposed to be an effective method for preventing and treating malnutrition in children with CKD 5. However, further multi-centric studies with larger sample size and longer duration of follow-up are still recommended.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33206228</pmid><doi>10.1007/s00467-020-04806-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3575-887X</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric nephrology (Berlin, West), 2021-06, Vol.36 (6), p.1561-1569 |
| issn | 0931-041X 1432-198X |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adipose tissue Albumin Amino Acids Body composition Care and treatment Child Child Nutrition Disorders Children Cholesterol Chronic kidney failure Complications and side effects Dialysis Hand Strength Health aspects Humans Intravenous administration Kidney diseases Kidney Failure, Chronic Malnutrition Malnutrition - etiology Malnutrition - prevention & control Malnutrition in children Medicine Medicine & Public Health Methods Morbidity Nephrology Nutritional Status Original Article Parenteral feeding Parenteral nutrition Parenteral therapy Pediatric research Pediatrics Placebos Prospective Studies Protein-Energy Malnutrition Renal Dialysis - adverse effects Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - therapy Urology What’s New in Chronic Kidney Disease |
| title | Efficacy of intradialytic amino acids on nutritional status in children with stage 5 chronic kidney disease |
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