Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score
Acute kidney injury (AKI) after major trauma is associated with increased mortality. The aim of this study was to assess if measurement of blood biomarkers in combination with clinical characteristics could be used to develop a tool to assist clinicians in identifying which orthopaedic trauma patien...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.20005, Article 20005 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 20005 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Kurth, Mary Jo McBride, William T. McLean, Gavin Watt, Joanne Domanska, Anna Lamont, John V. Maguire, Daniel Fitzgerald, Peter Ruddock, Mark W. |
| description | Acute kidney injury (AKI) after major trauma is associated with increased mortality. The aim of this study was to assess if measurement of blood biomarkers in combination with clinical characteristics could be used to develop a tool to assist clinicians in identifying which orthopaedic trauma patients are at risk of AKI. This is a prospective study of 237 orthopaedic trauma patients who were consecutively scheduled for open reduction and internal fixation of their fracture between May 2012 and August 2013. Clinical characteristics were recorded, and 28 biomarkers were analysed in patient blood samples. Post operatively a combination of H-FABP, sTNFR1 and MK had the highest predictive ability to identify patients at risk of developing AKI (AUROC 0.885). Three clinical characteristics; age, dementia and hypertension were identified in the orthopaedic trauma patients as potential risks for the development of AKI. Combining biomarker data with clinical characteristics allowed us to develop a proactive AKI clinical tool, which grouped patients into four risk categories that were associated with a clinical management regime that impacted patient care, management, length of hospital stay, and efficient use of hospital resources. |
| doi_str_mv | 10.1038/s41598-020-76929-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2461862199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2461862199</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-f27ab9f5b2e04b6918194c9b536cdab6c9da267682e6d738e19c107fe379c4d63</originalsourceid><addsrcrecordid>eNqNkkuLFDEUhQtRnGGcP-BCAm4EKc2rkspGGBpfMOBG1yGVSnWnuzopk5RSO3-6d6bGdnQhZpML-c7NPZxbVU8JfkUwa19nThrV1pjiWgpFVb08qM4p5k1NGaUP79Vn1WXOewynoYoT9bg6Y4xipgQ7r35c2bk4dPB9cAvyYT-nBSWfD1CjmMouTsb13qKSzHw0aDLFu1AympJDJvRoirmgPKetA-GcfdgigzofjyYdXEJm3Mbky-54C9vRB2_NuP6QbUzuSfVoMGN2l3f3RfXl3dvPmw_19af3HzdX17Xlkpd6oNJ0amg66jDvhCItUdyqrmHC9qYTVvWGCila6kQvWeuIsgTLwTGpLO8Fu6jerH2nuTu63oKJZEY9JQ-TLjoar_98CX6nt_GblkIywjA0eHHXIMWvs8tFH322bhxNcHHOmnJBWkGJUoA-_wvdxzkFsAeUJI3knDdA0ZWyKeac3HAahmB9k7FeM9aQsb7NWC8genbfxknyK1EA2hX47ro4ZAtpWXfCYAkE7AURN-tAm40vkGcMmziHAtKX_y8Fmq10BiJA_L9N_mP-n1DC1h4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471574445</pqid></control><display><type>article</type><title>Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score</title><source>Natureオープンアクセス</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Kurth, Mary Jo ; McBride, William T. ; McLean, Gavin ; Watt, Joanne ; Domanska, Anna ; Lamont, John V. ; Maguire, Daniel ; Fitzgerald, Peter ; Ruddock, Mark W.</creator><creatorcontrib>Kurth, Mary Jo ; McBride, William T. ; McLean, Gavin ; Watt, Joanne ; Domanska, Anna ; Lamont, John V. ; Maguire, Daniel ; Fitzgerald, Peter ; Ruddock, Mark W.</creatorcontrib><description>Acute kidney injury (AKI) after major trauma is associated with increased mortality. The aim of this study was to assess if measurement of blood biomarkers in combination with clinical characteristics could be used to develop a tool to assist clinicians in identifying which orthopaedic trauma patients are at risk of AKI. This is a prospective study of 237 orthopaedic trauma patients who were consecutively scheduled for open reduction and internal fixation of their fracture between May 2012 and August 2013. Clinical characteristics were recorded, and 28 biomarkers were analysed in patient blood samples. Post operatively a combination of H-FABP, sTNFR1 and MK had the highest predictive ability to identify patients at risk of developing AKI (AUROC 0.885). Three clinical characteristics; age, dementia and hypertension were identified in the orthopaedic trauma patients as potential risks for the development of AKI. Combining biomarker data with clinical characteristics allowed us to develop a proactive AKI clinical tool, which grouped patients into four risk categories that were associated with a clinical management regime that impacted patient care, management, length of hospital stay, and efficient use of hospital resources.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-76929-y</identifier><identifier>PMID: 33203963</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308 ; 692/4022 ; 692/420 ; 692/499 ; 692/53 ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers - blood ; Blood ; Dementia ; Dementia disorders ; Fatty Acid Binding Protein 3 - blood ; Fatty acid-binding protein ; Female ; Health risks ; Humanities and Social Sciences ; Humans ; Hypertension ; Kidneys ; Male ; Midkine - blood ; multidisciplinary ; Multidisciplinary Sciences ; Musculoskeletal Diseases - complications ; Orthopedics ; Patients ; Perioperative Care - methods ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Surgery ; Trauma ; Trauma centers ; Tumor Necrosis Factor-alpha - blood ; Wounds and Injuries - blood ; Wounds and Injuries - complications ; Wounds and Injuries - surgery</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.20005, Article 20005</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000604516000025</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c474t-f27ab9f5b2e04b6918194c9b536cdab6c9da267682e6d738e19c107fe379c4d63</citedby><cites>FETCH-LOGICAL-c474t-f27ab9f5b2e04b6918194c9b536cdab6c9da267682e6d738e19c107fe379c4d63</cites><orcidid>0000-0001-8566-3572 ; 0000-0002-9839-134X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673130/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673130/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27928,27929,41124,42193,51580,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33203963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurth, Mary Jo</creatorcontrib><creatorcontrib>McBride, William T.</creatorcontrib><creatorcontrib>McLean, Gavin</creatorcontrib><creatorcontrib>Watt, Joanne</creatorcontrib><creatorcontrib>Domanska, Anna</creatorcontrib><creatorcontrib>Lamont, John V.</creatorcontrib><creatorcontrib>Maguire, Daniel</creatorcontrib><creatorcontrib>Fitzgerald, Peter</creatorcontrib><creatorcontrib>Ruddock, Mark W.</creatorcontrib><title>Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>SCI REP-UK</addtitle><addtitle>Sci Rep</addtitle><description>Acute kidney injury (AKI) after major trauma is associated with increased mortality. The aim of this study was to assess if measurement of blood biomarkers in combination with clinical characteristics could be used to develop a tool to assist clinicians in identifying which orthopaedic trauma patients are at risk of AKI. This is a prospective study of 237 orthopaedic trauma patients who were consecutively scheduled for open reduction and internal fixation of their fracture between May 2012 and August 2013. Clinical characteristics were recorded, and 28 biomarkers were analysed in patient blood samples. Post operatively a combination of H-FABP, sTNFR1 and MK had the highest predictive ability to identify patients at risk of developing AKI (AUROC 0.885). Three clinical characteristics; age, dementia and hypertension were identified in the orthopaedic trauma patients as potential risks for the development of AKI. Combining biomarker data with clinical characteristics allowed us to develop a proactive AKI clinical tool, which grouped patients into four risk categories that were associated with a clinical management regime that impacted patient care, management, length of hospital stay, and efficient use of hospital resources.</description><subject>692/308</subject><subject>692/4022</subject><subject>692/420</subject><subject>692/499</subject><subject>692/53</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Fatty Acid Binding Protein 3 - blood</subject><subject>Fatty acid-binding protein</subject><subject>Female</subject><subject>Health risks</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidneys</subject><subject>Male</subject><subject>Midkine - blood</subject><subject>multidisciplinary</subject><subject>Multidisciplinary Sciences</subject><subject>Musculoskeletal Diseases - complications</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Perioperative Care - methods</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Science (multidisciplinary)</subject><subject>Surgery</subject><subject>Trauma</subject><subject>Trauma centers</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Wounds and Injuries - blood</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - surgery</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkkuLFDEUhQtRnGGcP-BCAm4EKc2rkspGGBpfMOBG1yGVSnWnuzopk5RSO3-6d6bGdnQhZpML-c7NPZxbVU8JfkUwa19nThrV1pjiWgpFVb08qM4p5k1NGaUP79Vn1WXOewynoYoT9bg6Y4xipgQ7r35c2bk4dPB9cAvyYT-nBSWfD1CjmMouTsb13qKSzHw0aDLFu1AympJDJvRoirmgPKetA-GcfdgigzofjyYdXEJm3Mbky-54C9vRB2_NuP6QbUzuSfVoMGN2l3f3RfXl3dvPmw_19af3HzdX17Xlkpd6oNJ0amg66jDvhCItUdyqrmHC9qYTVvWGCila6kQvWeuIsgTLwTGpLO8Fu6jerH2nuTu63oKJZEY9JQ-TLjoar_98CX6nt_GblkIywjA0eHHXIMWvs8tFH322bhxNcHHOmnJBWkGJUoA-_wvdxzkFsAeUJI3knDdA0ZWyKeac3HAahmB9k7FeM9aQsb7NWC8genbfxknyK1EA2hX47ro4ZAtpWXfCYAkE7AURN-tAm40vkGcMmziHAtKX_y8Fmq10BiJA_L9N_mP-n1DC1h4</recordid><startdate>20201117</startdate><enddate>20201117</enddate><creator>Kurth, Mary Jo</creator><creator>McBride, William T.</creator><creator>McLean, Gavin</creator><creator>Watt, Joanne</creator><creator>Domanska, Anna</creator><creator>Lamont, John V.</creator><creator>Maguire, Daniel</creator><creator>Fitzgerald, Peter</creator><creator>Ruddock, Mark W.</creator><general>Nature Publishing Group UK</general><general>NATURE PORTFOLIO</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8566-3572</orcidid><orcidid>https://orcid.org/0000-0002-9839-134X</orcidid></search><sort><creationdate>20201117</creationdate><title>Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score</title><author>Kurth, Mary Jo ; McBride, William T. ; McLean, Gavin ; Watt, Joanne ; Domanska, Anna ; Lamont, John V. ; Maguire, Daniel ; Fitzgerald, Peter ; Ruddock, Mark W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-f27ab9f5b2e04b6918194c9b536cdab6c9da267682e6d738e19c107fe379c4d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/308</topic><topic>692/4022</topic><topic>692/420</topic><topic>692/499</topic><topic>692/53</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Fatty Acid Binding Protein 3 - blood</topic><topic>Fatty acid-binding protein</topic><topic>Female</topic><topic>Health risks</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Kidneys</topic><topic>Male</topic><topic>Midkine - blood</topic><topic>multidisciplinary</topic><topic>Multidisciplinary Sciences</topic><topic>Musculoskeletal Diseases - complications</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Perioperative Care - methods</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><topic>Science (multidisciplinary)</topic><topic>Surgery</topic><topic>Trauma</topic><topic>Trauma centers</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Wounds and Injuries - blood</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurth, Mary Jo</creatorcontrib><creatorcontrib>McBride, William T.</creatorcontrib><creatorcontrib>McLean, Gavin</creatorcontrib><creatorcontrib>Watt, Joanne</creatorcontrib><creatorcontrib>Domanska, Anna</creatorcontrib><creatorcontrib>Lamont, John V.</creatorcontrib><creatorcontrib>Maguire, Daniel</creatorcontrib><creatorcontrib>Fitzgerald, Peter</creatorcontrib><creatorcontrib>Ruddock, Mark W.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurth, Mary Jo</au><au>McBride, William T.</au><au>McLean, Gavin</au><au>Watt, Joanne</au><au>Domanska, Anna</au><au>Lamont, John V.</au><au>Maguire, Daniel</au><au>Fitzgerald, Peter</au><au>Ruddock, Mark W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2020-11-17</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>20005</spage><pages>20005-</pages><artnum>20005</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Acute kidney injury (AKI) after major trauma is associated with increased mortality. The aim of this study was to assess if measurement of blood biomarkers in combination with clinical characteristics could be used to develop a tool to assist clinicians in identifying which orthopaedic trauma patients are at risk of AKI. This is a prospective study of 237 orthopaedic trauma patients who were consecutively scheduled for open reduction and internal fixation of their fracture between May 2012 and August 2013. Clinical characteristics were recorded, and 28 biomarkers were analysed in patient blood samples. Post operatively a combination of H-FABP, sTNFR1 and MK had the highest predictive ability to identify patients at risk of developing AKI (AUROC 0.885). Three clinical characteristics; age, dementia and hypertension were identified in the orthopaedic trauma patients as potential risks for the development of AKI. Combining biomarker data with clinical characteristics allowed us to develop a proactive AKI clinical tool, which grouped patients into four risk categories that were associated with a clinical management regime that impacted patient care, management, length of hospital stay, and efficient use of hospital resources.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33203963</pmid><doi>10.1038/s41598-020-76929-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8566-3572</orcidid><orcidid>https://orcid.org/0000-0002-9839-134X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-11, Vol.10 (1), p.20005, Article 20005 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2461862199 |
| source | Natureオープンアクセス; MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/308 692/4022 692/420 692/499 692/53 Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Age Factors Aged Aged, 80 and over Biomarkers Biomarkers - blood Blood Dementia Dementia disorders Fatty Acid Binding Protein 3 - blood Fatty acid-binding protein Female Health risks Humanities and Social Sciences Humans Hypertension Kidneys Male Midkine - blood multidisciplinary Multidisciplinary Sciences Musculoskeletal Diseases - complications Orthopedics Patients Perioperative Care - methods Predictive Value of Tests Prospective Studies Risk Factors Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Surgery Trauma Trauma centers Tumor Necrosis Factor-alpha - blood Wounds and Injuries - blood Wounds and Injuries - complications Wounds and Injuries - surgery |
| title | Acute kidney injury risk in orthopaedic trauma patients pre and post surgery using a biomarker algorithm and clinical risk score |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T06%3A51%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20kidney%20injury%20risk%20in%20orthopaedic%20trauma%20patients%20pre%20and%20post%20surgery%20using%20a%20biomarker%20algorithm%20and%20clinical%20risk%20score&rft.jtitle=Scientific%20reports&rft.au=Kurth,%20Mary%20Jo&rft.date=2020-11-17&rft.volume=10&rft.issue=1&rft.spage=20005&rft.pages=20005-&rft.artnum=20005&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-76929-y&rft_dat=%3Cproquest_pubme%3E2461862199%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471574445&rft_id=info:pmid/33203963&rfr_iscdi=true |