Transglutaminase Type 2 is Involved in the Hematopoietic Stem Cells Homeostasis
Type 2 transglutaminase (TG2) is a multifunctional protein involved in various biological processes playing a key regulatory role in cell homeostasis such as cell death and autophagy. New evidence is emerging that support an important role of autophagy in regulating normal hematopoiesis. Prompted by...
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| Veröffentlicht in: | Biochemistry (Moscow) 2020-10, Vol.85 (10), p.1159-1168 |
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| creator | Oliverio, S. Beltran, J. S. O. Occhigrossi, L. Bordoni, V. Agrati, C. D’Eletto, M. Rossin, F. Borelli, P. Amarante-Mendes, G. P. Demidov, O. Barlev, N. A. Piacentini, M. |
| description | Type 2 transglutaminase (TG2) is a multifunctional protein involved in various biological processes playing a key regulatory role in cell homeostasis such as cell death and autophagy. New evidence is emerging that support an important role of autophagy in regulating normal hematopoiesis. Prompted by these findings, in this study we investigated
in vivo
involvement of TG2 in mouse hematopoiesis under normal or nutrient deprivation conditions. We found that the number and rate of differentiation of bone marrow hematopoietic stem cell was decreased in the TG2 knockout mice. We present evidence showing that these effects on hematopoietic system are very likely due to the TG2-dependent impairment of autophagy. In fact, stimulation of autophagy by starvation is able to rescue the block of the differentiation of stem cells progenitors in the TG2 KO mice. It was also shown that the RhoA/ERK½ pathway, known to be essential for regulation of the bone marrow progenitor cells homeostasis, was significantly impaired in the absence of TG2. Hence, this study expanded our knowledge about TG2 discovering a role of this enzyme in regulation of hematopoiesis. |
| doi_str_mv | 10.1134/S0006297920100041 |
| format | Article |
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in vivo
involvement of TG2 in mouse hematopoiesis under normal or nutrient deprivation conditions. We found that the number and rate of differentiation of bone marrow hematopoietic stem cell was decreased in the TG2 knockout mice. We present evidence showing that these effects on hematopoietic system are very likely due to the TG2-dependent impairment of autophagy. In fact, stimulation of autophagy by starvation is able to rescue the block of the differentiation of stem cells progenitors in the TG2 KO mice. It was also shown that the RhoA/ERK½ pathway, known to be essential for regulation of the bone marrow progenitor cells homeostasis, was significantly impaired in the absence of TG2. Hence, this study expanded our knowledge about TG2 discovering a role of this enzyme in regulation of hematopoiesis.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297920100041</identifier><identifier>PMID: 33202201</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animals ; Autophagy ; Biochemistry ; Biological activity ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Bone marrow ; Cell death ; Cell Differentiation ; Cells, Cultured ; Deprivation ; Differentiation ; Female ; GTP-Binding Proteins - physiology ; Hematopoiesis ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - metabolism ; Hematopoietic system ; Homeostasis ; In vivo methods and tests ; Life Sciences ; MAP Kinase Signaling System ; Metabolic pathways ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microbiology ; Osteoprogenitor cells ; Phagocytosis ; Progenitor cells ; RhoA protein ; Stem cell transplantation ; Stem cells ; Transglutaminase 2 ; Transglutaminases - physiology</subject><ispartof>Biochemistry (Moscow), 2020-10, Vol.85 (10), p.1159-1168</ispartof><rights>Pleiades Publishing, Ltd. 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Pleiades Publishing, Ltd. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c391t-70f7c947b942a93462eb801ab2506b1f4384f70e1061fe9598a4eeb3046189773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297920100041$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297920100041$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33202201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliverio, S.</creatorcontrib><creatorcontrib>Beltran, J. S. O.</creatorcontrib><creatorcontrib>Occhigrossi, L.</creatorcontrib><creatorcontrib>Bordoni, V.</creatorcontrib><creatorcontrib>Agrati, C.</creatorcontrib><creatorcontrib>D’Eletto, M.</creatorcontrib><creatorcontrib>Rossin, F.</creatorcontrib><creatorcontrib>Borelli, P.</creatorcontrib><creatorcontrib>Amarante-Mendes, G. P.</creatorcontrib><creatorcontrib>Demidov, O.</creatorcontrib><creatorcontrib>Barlev, N. A.</creatorcontrib><creatorcontrib>Piacentini, M.</creatorcontrib><title>Transglutaminase Type 2 is Involved in the Hematopoietic Stem Cells Homeostasis</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>Type 2 transglutaminase (TG2) is a multifunctional protein involved in various biological processes playing a key regulatory role in cell homeostasis such as cell death and autophagy. New evidence is emerging that support an important role of autophagy in regulating normal hematopoiesis. Prompted by these findings, in this study we investigated
in vivo
involvement of TG2 in mouse hematopoiesis under normal or nutrient deprivation conditions. We found that the number and rate of differentiation of bone marrow hematopoietic stem cell was decreased in the TG2 knockout mice. We present evidence showing that these effects on hematopoietic system are very likely due to the TG2-dependent impairment of autophagy. In fact, stimulation of autophagy by starvation is able to rescue the block of the differentiation of stem cells progenitors in the TG2 KO mice. It was also shown that the RhoA/ERK½ pathway, known to be essential for regulation of the bone marrow progenitor cells homeostasis, was significantly impaired in the absence of TG2. Hence, this study expanded our knowledge about TG2 discovering a role of this enzyme in regulation of hematopoiesis.</description><subject>Animals</subject><subject>Autophagy</subject><subject>Biochemistry</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Bone marrow</subject><subject>Cell death</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Deprivation</subject><subject>Differentiation</subject><subject>Female</subject><subject>GTP-Binding Proteins - physiology</subject><subject>Hematopoiesis</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Hematopoietic system</subject><subject>Homeostasis</subject><subject>In vivo methods and tests</subject><subject>Life Sciences</subject><subject>MAP Kinase Signaling System</subject><subject>Metabolic pathways</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Microbiology</subject><subject>Osteoprogenitor cells</subject><subject>Phagocytosis</subject><subject>Progenitor cells</subject><subject>RhoA protein</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transglutaminase 2</subject><subject>Transglutaminases - physiology</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1v1DAQhi0EokvhB3BBlrhwSZmxvXF8rFbAVqrUQ5dz5GQni6vEXmynUv89jrYU8SUf7PE87-sZD2NvES4Qpfp4CwC1MNoIwHJU-IytsIamkqDgOVst6WrJn7FXKd2VUICRL9mZlAJEEa3YzS5anw7jnO3kvE3Edw9H4oK7xK_8fRjvac-d5_kb8S1NNodjcJRdz28zTXxD45j4NkwUUrbJpdfsxWDHRG8e93P29fOn3WZbXd98udpcXle9NJgrDYPujdKdUcIaqWpBXQNoO7GGusNByUYNGgihxoHM2jRWEXWlrxobo7U8Zx9OvscYvs-Ucju51JdqrKcwp1Ys4Lq8sKDv_0Dvwhx9qa5QGptGQvmVJ-pgR2qdH0KOtl9M28taGg2IuC7UxT-osvY0uT54Gly5_02AJ0EfQ0qRhvYY3WTjQ4vQLkNs_xpi0bx7LHjuJto_KX5OrQDiBKSS8geKvzr6v-sPYYKhaQ</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Oliverio, S.</creator><creator>Beltran, J. 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S. O.</au><au>Occhigrossi, L.</au><au>Bordoni, V.</au><au>Agrati, C.</au><au>D’Eletto, M.</au><au>Rossin, F.</au><au>Borelli, P.</au><au>Amarante-Mendes, G. P.</au><au>Demidov, O.</au><au>Barlev, N. A.</au><au>Piacentini, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transglutaminase Type 2 is Involved in the Hematopoietic Stem Cells Homeostasis</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>85</volume><issue>10</issue><spage>1159</spage><epage>1168</epage><pages>1159-1168</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>Type 2 transglutaminase (TG2) is a multifunctional protein involved in various biological processes playing a key regulatory role in cell homeostasis such as cell death and autophagy. New evidence is emerging that support an important role of autophagy in regulating normal hematopoiesis. Prompted by these findings, in this study we investigated
in vivo
involvement of TG2 in mouse hematopoiesis under normal or nutrient deprivation conditions. We found that the number and rate of differentiation of bone marrow hematopoietic stem cell was decreased in the TG2 knockout mice. We present evidence showing that these effects on hematopoietic system are very likely due to the TG2-dependent impairment of autophagy. In fact, stimulation of autophagy by starvation is able to rescue the block of the differentiation of stem cells progenitors in the TG2 KO mice. It was also shown that the RhoA/ERK½ pathway, known to be essential for regulation of the bone marrow progenitor cells homeostasis, was significantly impaired in the absence of TG2. Hence, this study expanded our knowledge about TG2 discovering a role of this enzyme in regulation of hematopoiesis.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>33202201</pmid><doi>10.1134/S0006297920100041</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Autophagy Biochemistry Biological activity Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Bone marrow Cell death Cell Differentiation Cells, Cultured Deprivation Differentiation Female GTP-Binding Proteins - physiology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Hematopoietic system Homeostasis In vivo methods and tests Life Sciences MAP Kinase Signaling System Metabolic pathways Mice Mice, Inbred C57BL Mice, Knockout Microbiology Osteoprogenitor cells Phagocytosis Progenitor cells RhoA protein Stem cell transplantation Stem cells Transglutaminase 2 Transglutaminases - physiology |
| title | Transglutaminase Type 2 is Involved in the Hematopoietic Stem Cells Homeostasis |
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