Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts

Objective Double‐strand (ds) DNA‐enveloped viruses can cause oral infection. Our aim is to investigate whether oral mucosal cells participate in immune response against cytosolic dsDNA invasion. Methods We examined the response to transfected herpes simplex virus (HSV) dsDNA via intracellular recept...

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Veröffentlicht in:	Oral diseases 2022-01, Vol.28 (1), p.150-163
Hauptverfasser:	Naruse, Takako, Ohta, Kouji, Kato, Hiroki, Ishida, Yoko, Shigeishi, Hideo, Sakuma, Miyuki, Fukui, Akiko, Nakagawa, Takayuki, Tobiume, Kei, Nishi, Hiromi, Takechi, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Restriction Factors - immunology Cell activation Cell Line Chemokine CXCL10 - immunology CXCL10 protein Cytoplasm cytosolic DNA Deoxyribonucleic acid DNA DNA viruses DNA, Viral - immunology Fibroblasts Fibroblasts - immunology Herpes simplex Humans IFI16 Immune response Immunity Immunomodulation Intracellular Keratinocytes Keratinocytes - immunology Mucosal immunity Nuclear Proteins - immunology Nuclear transport oral fibroblasts Oral infection oral keratinocytes Phosphoproteins - immunology Receptors, Retinoic Acid - immunology RIG‐I Simplexvirus - immunology TNF‐α Tumor necrosis factor Tumor Necrosis Factor-alpha - immunology
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