Mitochondria-ER Tethering in Neurodegenerative Diseases
Organelles juxtaposition has been detected for decades, although only recently gained importance due to a pivotal role in the regulation of cellular processes dependent on membrane contact sites. Endoplasmic reticulum (ER) and mitochondria interaction is a prime example of organelles contact sites....
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| Veröffentlicht in: | Cellular and molecular neurobiology 2022-05, Vol.42 (4), p.917-930 |
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| creator | Raeisossadati, Reza Ferrari, Merari F. R. |
| description | Organelles juxtaposition has been detected for decades, although only recently gained importance due to a pivotal role in the regulation of cellular processes dependent on membrane contact sites. Endoplasmic reticulum (ER) and mitochondria interaction is a prime example of organelles contact sites. Mitochondria-associated membranes (MAM) are proposed to harbor ER-mitochondria tether complexes, mainly when these organelles are less than 30 nm apart. Dysfunctions of proteins located at the MAM are associated with neurodegenerative diseases such as Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis, as well as neurodevelopmental disorders; hence any malfunction in MAM can potentially trigger cell death. This review will focus on the role of ER-mitochondria contact sites, regarding calcium homeostasis, lipid metabolism, autophagy, morphology and dynamics of mitochondria, mainly in the context of neurodegenerative diseases. Approaches that have been employed so far to study organelles contact sites, as well as methods that were not used in neurosciences yet, but are promising and accurate ways to unveil the functions of MAM during neurodegeneration, is also discussed in the present review. |
| doi_str_mv | 10.1007/s10571-020-01008-9 |
| format | Article |
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R.</creatorcontrib><title>Mitochondria-ER Tethering in Neurodegenerative Diseases</title><title>Cellular and molecular neurobiology</title><addtitle>Cell Mol Neurobiol</addtitle><addtitle>Cell Mol Neurobiol</addtitle><description>Organelles juxtaposition has been detected for decades, although only recently gained importance due to a pivotal role in the regulation of cellular processes dependent on membrane contact sites. Endoplasmic reticulum (ER) and mitochondria interaction is a prime example of organelles contact sites. Mitochondria-associated membranes (MAM) are proposed to harbor ER-mitochondria tether complexes, mainly when these organelles are less than 30 nm apart. Dysfunctions of proteins located at the MAM are associated with neurodegenerative diseases such as Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis, as well as neurodevelopmental disorders; hence any malfunction in MAM can potentially trigger cell death. 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Approaches that have been employed so far to study organelles contact sites, as well as methods that were not used in neurosciences yet, but are promising and accurate ways to unveil the functions of MAM during neurodegeneration, is also discussed in the present review.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Autophagy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium homeostasis</subject><subject>Calcium metabolism</subject><subject>Cell Biology</subject><subject>Cell Death</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Lipid metabolism</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondrial Membranes</subject><subject>Neurobiology</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Neurodevelopmental disorders</subject><subject>Neurosciences</subject><subject>Organelles</subject><subject>Review Paper</subject><issn>0272-4340</issn><issn>1573-6830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-AQ8S8OJldfYrmz1KrR9QFaSel00yaVPapO4mgv_e1FQFD54GhmfeeXkIOWVwyQD0VWCgNKPAgUK3SKjZI0OmtKBxImCfDIFrTqWQMCBHISwBwACoQzIQgpnYaDkk-rFs6mxRV7kvHZ28RDNsFujLah6VVfSEra9znGOF3jXlO0Y3ZUAXMByTg8KtAp7s5oi83k5m43s6fb57GF9PaSYla6iGNHeFAMcLVXATC4w54046bXQhBRZ5ComUoAzT4CBJdG50IriSSqRJbsSIXPS5G1-_tRgauy5DhquVq7Bug-UyZsLETEGHnv9Bl3Xrq66d5bHkQmujko7iPZX5OgSPhd34cu38h2Vgt1ptr9V2Wu2XVrttcbaLbtM15j8n3x47QPRA2Gzdof_9_U_sJ3TEf-o</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Raeisossadati, Reza</creator><creator>Ferrari, Merari F. 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| subjects | Amyotrophic lateral sclerosis Autophagy Biomedical and Life Sciences Biomedicine Calcium homeostasis Calcium metabolism Cell Biology Cell Death Endoplasmic reticulum Endoplasmic Reticulum - metabolism Homeostasis Humans Lipid metabolism Mitochondria Mitochondria - metabolism Mitochondrial Membranes Neurobiology Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodevelopmental disorders Neurosciences Organelles Review Paper |
| title | Mitochondria-ER Tethering in Neurodegenerative Diseases |
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