Chronic modafinil administration to preadolescent rats impairs social play behavior and dopaminergic system

Some clinical trials are investigating modafinil (Mod) as a treatment for attentional deficit and hyperactivity disorder (ADHD) in children and adolescents. Mod increases dopamine (DA) levels in the reward system by blocking dopamine transporter (DAT). Social interactions are rewarding behaviors and...

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Veröffentlicht in:	Neuropharmacology 2021-02, Vol.183, p.108404-108404, Article 108404
Hauptverfasser:	Cid-Jofré, Valeska, Gárate-Pérez, Macarena, Clark, Philip J., Valero-Jara, Viviana, España, Rodrigo A., Sotomayor-Zárate, Ramón, Cruz, Gonzalo, Renard, Georgina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System Stimulants - pharmacology Dopamine Dopamine - metabolism Dopaminergic Neurons - drug effects Locomotor activity Modafinil Modafinil - pharmacology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - metabolism Reward Social Interaction - drug effects Social play behavior
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