Influence of single nucleotide polymorphism of LAT1 on therapeutic response to gabapentinoids in Pakistani patients with neuropathic pain

Gabapentinoids are substrate of L‐type amino acid transporter 1 (LAT1) for distribution across the blood‐brain barrier. The present study aimed to evaluate the effect of LAT1 rs4240803 genetic polymorphism on the clinical efficacy and tolerability of gabapentinoids in Pakistani patients with neuropa...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2021-03, Vol.128 (3), p.503-510
Hauptverfasser:	Shaheen, Abida, Alam, Syed Mahboob, Azam, Fahad, Khan, Moosa, Ahmad Saleem, Salman, Liaquat, Afrose, Mumtaz, Sana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Amino acids Blood-brain barrier gabapentin Gene polymorphism Genotype & phenotype Neuralgia neuropathic pain Nucleotides Pain Patients Pharmacogenetics Polymorphism pregabalin Single-nucleotide polymorphism Substrates
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