Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations
We present an approach for the elucidation of C=C bond position and cis/trans isomers, which is achieved by the reaction of ambient water radical cations and double bonds, followed by the fragmentation of epoxide radical cations to generate diagnostic ions in tandem mass spectrometry. Hexenol double...
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| Veröffentlicht in: | Analytica chimica acta 2020-12, Vol.1139, p.146-154 |
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| container_title | Analytica chimica acta |
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| creator | Zhang, Xiaoping Ren, Xiang Chingin, Konstantin Xu, Jiaquan Yan, Xin Chen, Huanwen |
| description | We present an approach for the elucidation of C=C bond position and cis/trans isomers, which is achieved by the reaction of ambient water radical cations and double bonds, followed by the fragmentation of epoxide radical cations to generate diagnostic ions in tandem mass spectrometry. Hexenol double bond positional isomers and cis/trans isomers which exhibit different properties and biological functions are characterized as a proof of concept. The merits of the approach include the simplicity of experimental setup, rapid derivatization (within seconds), the obviation of organic solvents, as well as easy spectral interpretation.
[Display omitted]
•A novel approach for the elucidation of C=C bond position and cis/trans isomers.•In situ epoxidation reaction of ambient water radical cations and C=C bonds.•No need of special instrumentation and organic solvents. |
| doi_str_mv | 10.1016/j.aca.2020.09.027 |
| format | Article |
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[Display omitted]
•A novel approach for the elucidation of C=C bond position and cis/trans isomers.•In situ epoxidation reaction of ambient water radical cations and C=C bonds.•No need of special instrumentation and organic solvents.</description><identifier>ISSN: 0003-2670</identifier><identifier>EISSN: 1873-4324</identifier><identifier>DOI: 10.1016/j.aca.2020.09.027</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Ambient corona discharge ionization mass spectrometry ; Carbon-carbon double bond ; Cis/trans isomers ; Positional isomers ; Water radical cations</subject><ispartof>Analytica chimica acta, 2020-12, Vol.1139, p.146-154</ispartof><rights>2020 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-bc72d47734ddcc050385673f171bad93e2c0943b024e6900b6de7dc3ebeb1bcf3</citedby><cites>FETCH-LOGICAL-c330t-bc72d47734ddcc050385673f171bad93e2c0943b024e6900b6de7dc3ebeb1bcf3</cites><orcidid>0000-0002-5505-3578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.aca.2020.09.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Zhang, Xiaoping</creatorcontrib><creatorcontrib>Ren, Xiang</creatorcontrib><creatorcontrib>Chingin, Konstantin</creatorcontrib><creatorcontrib>Xu, Jiaquan</creatorcontrib><creatorcontrib>Yan, Xin</creatorcontrib><creatorcontrib>Chen, Huanwen</creatorcontrib><title>Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations</title><title>Analytica chimica acta</title><description>We present an approach for the elucidation of C=C bond position and cis/trans isomers, which is achieved by the reaction of ambient water radical cations and double bonds, followed by the fragmentation of epoxide radical cations to generate diagnostic ions in tandem mass spectrometry. Hexenol double bond positional isomers and cis/trans isomers which exhibit different properties and biological functions are characterized as a proof of concept. The merits of the approach include the simplicity of experimental setup, rapid derivatization (within seconds), the obviation of organic solvents, as well as easy spectral interpretation.
[Display omitted]
•A novel approach for the elucidation of C=C bond position and cis/trans isomers.•In situ epoxidation reaction of ambient water radical cations and C=C bonds.•No need of special instrumentation and organic solvents.</description><subject>Ambient corona discharge ionization mass spectrometry</subject><subject>Carbon-carbon double bond</subject><subject>Cis/trans isomers</subject><subject>Positional isomers</subject><subject>Water radical cations</subject><issn>0003-2670</issn><issn>1873-4324</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPAzEQhC0EEuHxA-hc0tyxti9nDKJAES8JRAO15bM3wdHlLngdUP49RqGm2tnVzEj7MXYmoBYg2otl7byrJUiowdQg9R6biEutqkbJZp9NAEBVstVwyI6IlmWVApoJSy-OiNMafU7jCnPa8hApx2GxifRRBp_dzHg_epfjOHA3BO4jXeTkBuKRSiTRFb_lVC4ZF1seh5hjkYF3W_5dROLJhehdz3cddMIO5q4nPP2bx-z9_u5t9lg9vz48zW6fK68U5KrzWoZGa9WE4D1MQV1OW63mQovOBaNQejCN6kA22BqArg2og1fYYSc6P1fH7HzXu07j5wYp21Ukj33vBhw3ZGXTgjFGG1msYmf1aSRKOLfrFFcuba0A-8vXLm3ha3_5WjC28C2Z610Gyw9fEZMlH3HwGGIqNG0Y4z_pH3dnhPA</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Zhang, Xiaoping</creator><creator>Ren, Xiang</creator><creator>Chingin, Konstantin</creator><creator>Xu, Jiaquan</creator><creator>Yan, Xin</creator><creator>Chen, Huanwen</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5505-3578</orcidid></search><sort><creationdate>20201201</creationdate><title>Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations</title><author>Zhang, Xiaoping ; Ren, Xiang ; Chingin, Konstantin ; Xu, Jiaquan ; Yan, Xin ; Chen, Huanwen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-bc72d47734ddcc050385673f171bad93e2c0943b024e6900b6de7dc3ebeb1bcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ambient corona discharge ionization mass spectrometry</topic><topic>Carbon-carbon double bond</topic><topic>Cis/trans isomers</topic><topic>Positional isomers</topic><topic>Water radical cations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaoping</creatorcontrib><creatorcontrib>Ren, Xiang</creatorcontrib><creatorcontrib>Chingin, Konstantin</creatorcontrib><creatorcontrib>Xu, Jiaquan</creatorcontrib><creatorcontrib>Yan, Xin</creatorcontrib><creatorcontrib>Chen, Huanwen</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Analytica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaoping</au><au>Ren, Xiang</au><au>Chingin, Konstantin</au><au>Xu, Jiaquan</au><au>Yan, Xin</au><au>Chen, Huanwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations</atitle><jtitle>Analytica chimica acta</jtitle><date>2020-12-01</date><risdate>2020</risdate><volume>1139</volume><spage>146</spage><epage>154</epage><pages>146-154</pages><issn>0003-2670</issn><eissn>1873-4324</eissn><abstract>We present an approach for the elucidation of C=C bond position and cis/trans isomers, which is achieved by the reaction of ambient water radical cations and double bonds, followed by the fragmentation of epoxide radical cations to generate diagnostic ions in tandem mass spectrometry. Hexenol double bond positional isomers and cis/trans isomers which exhibit different properties and biological functions are characterized as a proof of concept. The merits of the approach include the simplicity of experimental setup, rapid derivatization (within seconds), the obviation of organic solvents, as well as easy spectral interpretation.
[Display omitted]
•A novel approach for the elucidation of C=C bond position and cis/trans isomers.•In situ epoxidation reaction of ambient water radical cations and C=C bonds.•No need of special instrumentation and organic solvents.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.aca.2020.09.027</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5505-3578</orcidid></addata></record> |
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| subjects | Ambient corona discharge ionization mass spectrometry Carbon-carbon double bond Cis/trans isomers Positional isomers Water radical cations |
| title | Mass spectrometry distinguishing C=C location and cis/trans isomers: A strategy initiated by water radical cations |
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