New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs

In the early 1960's, at Professor Bern's laboratory, University of California, Berkeley) in the US, Takasugi discovered ovary-independent, persistent vaginal changes in mice exposed neonatally to estrogen, which resulted in vaginal cancer later in life. Reproductive abnormalities in rodent...

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Veröffentlicht in:	Differentiation (London) 2021-03, Vol.118, p.4-23
Hauptverfasser:	Iguchi, Taisen, Sato, Tomomi, Nakajima, Tadaaki, Miyagawa, Shinichi, Takasugi, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cell proliferation Cell Proliferation - drug effects Diethylstilbestrol Diethylstilbestrol - pharmacology Endocrine disruptors Endocrinology Epithelial cells Estrogen Receptor alpha - genetics Estrogen receptors Estrogens Estrogens - analogs & derivatives Estrogens - toxicity Female Follicles Gonadal Steroid Hormones - biosynthesis Gonadal Steroid Hormones - metabolism Growth factors Humans Irreversible changes Mice Muellerian duct Mullerian Ducts - drug effects Mullerian Ducts - metabolism Mullerian Ducts - pathology Müllerian duct differentiation Neonates Perinatal effects Perinatal exposure Phosphorylation Polyovular follicle Pregnancy Reproductive organs Sex hormones Stromal effects Vagina Vagina - drug effects Vagina - metabolism Vagina - pathology Vaginal Neoplasms - chemically induced Vaginal Neoplasms - genetics Vaginal Neoplasms - pathology Wildlife Xenoestrogens
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