Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clini...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2021-05, Vol.221, p.107741-107741, Article 107741
Hauptverfasser:	Kohtala, S., Alitalo, O., Rosenholm, M., Rozov, S., Rantamäki, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressive Agents - pharmacology Circadian Circadian Rhythm - drug effects Depression Humans Ketamine - pharmacology Plasticity Rapid-acting antidepressant Sleep Sleep - drug effects Slow-wave sleep Time Factors Wakefulness - drug effects
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