Modulation of Memory B Cell Phenotypes and Toll-Like Receptor-7 in Chronic Hepatitis C Virus Infection During Direct-Acting Antiviral Interferon-Free Therapy: Correlation with Interleukin-7

Hepatitis C virus (HCV) infection is a major worldwide problem with the highest incidence rates in Egypt. It affects B cells that serve as reservoirs for persistent HCV, resulting in phenotypic B cell alterations. Interleukin-7 (IL-7) is a cytokine with antiviral activity, important for B cell physi...

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Veröffentlicht in:	Viral immunology 2021-05, Vol.34 (4), p.227-240
Hauptverfasser:	Moustafa, Hanan, Madkour, Marwa, Hamed, Fathi, Abouelnazar, Salma, Abo Elwafa, Reham, Moaaz, Mai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral activity Antiviral agents Antiviral Agents - therapeutic use Antiviral drugs Chronic infection Cytokines Enzyme-linked immunosorbent assay Flow cytometry Gene expression Hepacivirus - genetics Hepatitis Hepatitis C Hepatitis C - drug therapy Hepatitis C, Chronic Humans Immunological memory Immunomodulation Immunosuppressive agents Infections Interferon Interferons - therapeutic use Interleukin 7 Lymphocytes B Memory B Cells - drug effects Memory cells Original Articles Phenotype Phenotypes Polymerase chain reaction Prospective Studies Remission TLR7 protein Toll-Like Receptor 7 - drug effects Toll-Like Receptor 7 - genetics Toll-like receptors Viral infections
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