Polyphenol Honokiol and Flavone 2′,3′,4′-Trihydroxyflavone Differentially Interact with α‑Synuclein at Distinct Phases of Aggregation

The association between protein aggregation and neurodegenerative diseases such as Parkinson’s disease continues to be well interrogated but poorly elucidated at a mechanistic level. Nevertheless, the formation of amyloid fibrils from the destabilization and misfolding of native proteins is a molecu...

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Veröffentlicht in:ACS chemical neuroscience 2020-12, Vol.11 (24), p.4469-4477
Hauptverfasser: Jovcevski, Blagojce, Das, Sukanya, Smid, Scott, Pukala, Tara Louise
Format: Artikel
Sprache:eng
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