Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells

•Romidepsin treatment decreases ACTH synthesis in corticotroph tumor cells.•Romidepsin suppresses cell proliferation via PTTG1.•HDAC1 is involved in the proliferation of corticotroph cells via PTTG1. Cushing’s disease is mainly caused by autonomous production of adrenocorticotropic hormone (ACTH) fr...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2021-02, Vol.136, p.170441-170441, Article 170441
Hauptverfasser:	Hagiwara, Rie, Kageyama, Kazunori, Niioka, Kanako, Takayasu, Shinobu, Tasso, Mizuki, Daimon, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic hormone Corticotroph tumor Cushing’s disease Histone deacetylase Proopiomelanocortin
Online-Zugang:	Volltext
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