Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil
•No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by c...
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Veröffentlicht in: | Cancer epidemiology 2020-12, Vol.69, p.101851-101851, Article 101851 |
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creator | Junqueira, Maria Elizangela Ramos de Oliveira, Claúdia T. Tone, Luiz G. Lee, Maria Lúcia de M. de Andréa, Maria Lydia M. Bruniera, Paula Epelman, Sidnei Odone Filho, Vicente Bonilha, Eliana de A. de Freitas, Marina Okamura, Mirna N. Vico, Eneida R. Stevens, Anthony P. Rabello Neto, Dácio de L Wünsch Filho, Victor |
description | •No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by caesarean section in the highest educational group had a reduced risk of ALL (NS).
Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL.
Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo.
Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI).
We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69).
We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL. |
doi_str_mv | 10.1016/j.canep.2020.101851 |
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Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL.
Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo.
Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI).
We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69).
We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2020.101851</identifier><identifier>PMID: 33186820</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Adult ; Age ; Birth weight ; Births ; Brazil ; Caesarean section ; Cancer ; Case-Control Studies ; Case-control study ; Cesarean section ; Cesarean Section - statistics & numerical data ; Child ; Child, Preschool ; Childhood ; Childhood acute lymphoblastic leukaemia ; Children ; Children & youth ; Confidence intervals ; Epidemiology ; Etiology ; Female ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Interviews ; Leukemia ; Mothers ; Population studies ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology ; Prenatal and postnatal conditions ; Regression analysis ; Risk analysis ; Risk Factors ; Sample size ; Statistical analysis ; São Paulo ; Young Adult</subject><ispartof>Cancer epidemiology, 2020-12, Vol.69, p.101851-101851, Article 101851</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-fafbe3a9b68a991ffd7ce82dbb89bac801d40565b077b8d07d01cd1f560950573</citedby><cites>FETCH-LOGICAL-c387t-fafbe3a9b68a991ffd7ce82dbb89bac801d40565b077b8d07d01cd1f560950573</cites><orcidid>0000-0003-3174-2990</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1877782120301855$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33186820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Junqueira, Maria Elizangela Ramos</creatorcontrib><creatorcontrib>de Oliveira, Claúdia T.</creatorcontrib><creatorcontrib>Tone, Luiz G.</creatorcontrib><creatorcontrib>Lee, Maria Lúcia de M.</creatorcontrib><creatorcontrib>de Andréa, Maria Lydia M.</creatorcontrib><creatorcontrib>Bruniera, Paula</creatorcontrib><creatorcontrib>Epelman, Sidnei</creatorcontrib><creatorcontrib>Odone Filho, Vicente</creatorcontrib><creatorcontrib>Bonilha, Eliana de A.</creatorcontrib><creatorcontrib>de Freitas, Marina</creatorcontrib><creatorcontrib>Okamura, Mirna N.</creatorcontrib><creatorcontrib>Vico, Eneida R.</creatorcontrib><creatorcontrib>Stevens, Anthony P.</creatorcontrib><creatorcontrib>Rabello Neto, Dácio de L</creatorcontrib><creatorcontrib>Wünsch Filho, Victor</creatorcontrib><title>Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>•No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by caesarean section in the highest educational group had a reduced risk of ALL (NS).
Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL.
Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo.
Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI).
We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69).
We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Birth weight</subject><subject>Births</subject><subject>Brazil</subject><subject>Caesarean section</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Case-control study</subject><subject>Cesarean section</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Childhood acute lymphoblastic leukaemia</subject><subject>Children</subject><subject>Children & youth</subject><subject>Confidence intervals</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Interviews</subject><subject>Leukemia</subject><subject>Mothers</subject><subject>Population studies</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</subject><subject>Prenatal and postnatal conditions</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sample size</subject><subject>Statistical analysis</subject><subject>São Paulo</subject><subject>Young Adult</subject><issn>1877-7821</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcuKFDEUhgtRnIs-gSABNy6m2qQuSUpwMTbeYEBhFNyFU8kpOm26UiYpoX2U2foovpjprnEWLlzl9v3nhPMVxRNGV4wy_mK70jDitKpodbyRLbtXnDIpRClk_fX-3b5iJ8VZjFtKOWesfVic1DWTXFb0tLhZA0YICCOJqJP1Y7wgU8AREjgCoyGTj2k5aT8ae0SOD3pjndl4bwjoOSFx-9208b2DmKwmDudvgDsLL8kl0RCxzPEUvCMxzWZP7EjSBsl1ghz1A7n-_cuTTzA7f0FeB_hp3aPiwQAu4uPb9bz48vbN5_X78urjuw_ry6tS11KkcoChxxq6nkvoOjYMRmiUlel72fWgJWWmoS1veypELw0VhjJt2NBy2rW0FfV58XypOwX_fcaY1M5Gjc7l6fo5qqrhVHDKuzajz_5Bt34OY_7dgWpk0zVdnal6oXTwMQYc1BTsDsJeMaoO6tRWHdWpgzq1qMupp7e1536H5i7z11UGXi0A5mH8sBhU1BZHjcaGrE4Zb__b4A_b0a2_</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Junqueira, Maria Elizangela Ramos</creator><creator>de Oliveira, Claúdia T.</creator><creator>Tone, Luiz G.</creator><creator>Lee, Maria Lúcia de M.</creator><creator>de Andréa, Maria Lydia M.</creator><creator>Bruniera, Paula</creator><creator>Epelman, Sidnei</creator><creator>Odone Filho, Vicente</creator><creator>Bonilha, Eliana de A.</creator><creator>de Freitas, Marina</creator><creator>Okamura, Mirna N.</creator><creator>Vico, Eneida R.</creator><creator>Stevens, Anthony P.</creator><creator>Rabello Neto, Dácio de L</creator><creator>Wünsch Filho, Victor</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3174-2990</orcidid></search><sort><creationdate>202012</creationdate><title>Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil</title><author>Junqueira, Maria Elizangela Ramos ; de Oliveira, Claúdia T. ; Tone, Luiz G. ; Lee, Maria Lúcia de M. ; de Andréa, Maria Lydia M. ; Bruniera, Paula ; Epelman, Sidnei ; Odone Filho, Vicente ; Bonilha, Eliana de A. ; de Freitas, Marina ; Okamura, Mirna N. ; Vico, Eneida R. ; Stevens, Anthony P. ; Rabello Neto, Dácio de L ; Wünsch Filho, Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-fafbe3a9b68a991ffd7ce82dbb89bac801d40565b077b8d07d01cd1f560950573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Birth weight</topic><topic>Births</topic><topic>Brazil</topic><topic>Caesarean section</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Case-control study</topic><topic>Cesarean section</topic><topic>Cesarean Section - statistics & numerical data</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Childhood acute lymphoblastic leukaemia</topic><topic>Children</topic><topic>Children & youth</topic><topic>Confidence intervals</topic><topic>Epidemiology</topic><topic>Etiology</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Interviews</topic><topic>Leukemia</topic><topic>Mothers</topic><topic>Population studies</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</topic><topic>Prenatal and postnatal conditions</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Sample size</topic><topic>Statistical analysis</topic><topic>São Paulo</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Junqueira, Maria Elizangela Ramos</creatorcontrib><creatorcontrib>de Oliveira, Claúdia T.</creatorcontrib><creatorcontrib>Tone, Luiz G.</creatorcontrib><creatorcontrib>Lee, Maria Lúcia de M.</creatorcontrib><creatorcontrib>de Andréa, Maria Lydia M.</creatorcontrib><creatorcontrib>Bruniera, Paula</creatorcontrib><creatorcontrib>Epelman, Sidnei</creatorcontrib><creatorcontrib>Odone Filho, Vicente</creatorcontrib><creatorcontrib>Bonilha, Eliana de A.</creatorcontrib><creatorcontrib>de Freitas, Marina</creatorcontrib><creatorcontrib>Okamura, Mirna N.</creatorcontrib><creatorcontrib>Vico, Eneida R.</creatorcontrib><creatorcontrib>Stevens, Anthony P.</creatorcontrib><creatorcontrib>Rabello Neto, Dácio de L</creatorcontrib><creatorcontrib>Wünsch Filho, Victor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Junqueira, Maria Elizangela Ramos</au><au>de Oliveira, Claúdia T.</au><au>Tone, Luiz G.</au><au>Lee, Maria Lúcia de M.</au><au>de Andréa, Maria Lydia M.</au><au>Bruniera, Paula</au><au>Epelman, Sidnei</au><au>Odone Filho, Vicente</au><au>Bonilha, Eliana de A.</au><au>de Freitas, Marina</au><au>Okamura, Mirna N.</au><au>Vico, Eneida R.</au><au>Stevens, Anthony P.</au><au>Rabello Neto, Dácio de L</au><au>Wünsch Filho, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>69</volume><spage>101851</spage><epage>101851</epage><pages>101851-101851</pages><artnum>101851</artnum><issn>1877-7821</issn><eissn>1877-783X</eissn><abstract>•No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by caesarean section in the highest educational group had a reduced risk of ALL (NS).
Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL.
Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo.
Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI).
We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69).
We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33186820</pmid><doi>10.1016/j.canep.2020.101851</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3174-2990</orcidid></addata></record> |
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subjects | Acute lymphoblastic leukemia Adolescent Adult Age Birth weight Births Brazil Caesarean section Cancer Case-Control Studies Case-control study Cesarean section Cesarean Section - statistics & numerical data Child Child, Preschool Childhood Childhood acute lymphoblastic leukaemia Children Children & youth Confidence intervals Epidemiology Etiology Female Hospitals Humans Infant Infant, Newborn Interviews Leukemia Mothers Population studies Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Prenatal and postnatal conditions Regression analysis Risk analysis Risk Factors Sample size Statistical analysis São Paulo Young Adult |
title | Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil |
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