Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil

•No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by c...

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Veröffentlicht in:Cancer epidemiology 2020-12, Vol.69, p.101851-101851, Article 101851
Hauptverfasser: Junqueira, Maria Elizangela Ramos, de Oliveira, Claúdia T., Tone, Luiz G., Lee, Maria Lúcia de M., de Andréa, Maria Lydia M., Bruniera, Paula, Epelman, Sidnei, Odone Filho, Vicente, Bonilha, Eliana de A., de Freitas, Marina, Okamura, Mirna N., Vico, Eneida R., Stevens, Anthony P., Rabello Neto, Dácio de L, Wünsch Filho, Victor
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container_end_page 101851
container_issue
container_start_page 101851
container_title Cancer epidemiology
container_volume 69
creator Junqueira, Maria Elizangela Ramos
de Oliveira, Claúdia T.
Tone, Luiz G.
Lee, Maria Lúcia de M.
de Andréa, Maria Lydia M.
Bruniera, Paula
Epelman, Sidnei
Odone Filho, Vicente
Bonilha, Eliana de A.
de Freitas, Marina
Okamura, Mirna N.
Vico, Eneida R.
Stevens, Anthony P.
Rabello Neto, Dácio de L
Wünsch Filho, Victor
description •No statistically significant associations between caesarean section and ALL were observed.•Children born by caesarean section had a slight non-significant (NS) increased risk of ALL.•Children under 3 years old born by caesarean section had the highest risk of ALL (NS).•Children of mothers born by caesarean section in the highest educational group had a reduced risk of ALL (NS). Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo. Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI). We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69). We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL.
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Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo. Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI). 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Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo. Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI). We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69). We found a tenuous suggestive association between caesarean sections and childhood ALL. 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de Oliveira, Claúdia T. ; Tone, Luiz G. ; Lee, Maria Lúcia de M. ; de Andréa, Maria Lydia M. ; Bruniera, Paula ; Epelman, Sidnei ; Odone Filho, Vicente ; Bonilha, Eliana de A. ; de Freitas, Marina ; Okamura, Mirna N. ; Vico, Eneida R. ; Stevens, Anthony P. ; Rabello Neto, Dácio de L ; Wünsch Filho, Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-fafbe3a9b68a991ffd7ce82dbb89bac801d40565b077b8d07d01cd1f560950573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Birth weight</topic><topic>Births</topic><topic>Brazil</topic><topic>Caesarean section</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Case-control study</topic><topic>Cesarean section</topic><topic>Cesarean Section - statistics &amp; numerical data</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Childhood acute lymphoblastic leukaemia</topic><topic>Children</topic><topic>Children &amp; 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Brazil has high rates of caesarean sections, which has been suggested as a risk factor for acute lymphoblastic leukaemia (ALL). In addition, some pre- and postnatal conditions have been identified as relevant in the etiology of ALL. Investigate the association of caesarean sections, pre- and postnatal conditions with childhood ALL in the State of São Paulo. Population-based case-control study including children that are below10 years old. Information on study variables was obtained through face to face interviews, through a questionnaire, and the State of São Paulo Declarations of Live Births database. The conditional and unconditional logistic regression approaches were used to calculate the odds ratio (OR) of the associations between caesarean sections, pre- and postnatal conditions with ALL, and 95 % confidence intervals (95 % CI). We observed a weak and non-statistically significant risk for ALL among children exposed to caesarean sections (unconditional logistic regression OR 1.08; 95 % CI 0.70–1.66; conditional logistic regression OR 1.21; 95 % CI 0.72–2.02), but among children under 3 years old and born through a caesarean sections, the risk of ALL was greater (unconditional logistic regression OR 1.70; 95 % CI 0.69–4.21). A negative association for ALL was observed among children with mothers who reported 12 years of schooling or more (unconditional logistic regression OR 0.34; 95 % CI 0.16−0.69). We found a tenuous suggestive association between caesarean sections and childhood ALL. The mother's high level of education showed an inverse association with ALL.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33186820</pmid><doi>10.1016/j.canep.2020.101851</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3174-2990</orcidid></addata></record>
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identifier ISSN: 1877-7821
ispartof Cancer epidemiology, 2020-12, Vol.69, p.101851-101851, Article 101851
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1877-783X
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Acute lymphoblastic leukemia
Adolescent
Adult
Age
Birth weight
Births
Brazil
Caesarean section
Cancer
Case-Control Studies
Case-control study
Cesarean section
Cesarean Section - statistics & numerical data
Child
Child, Preschool
Childhood
Childhood acute lymphoblastic leukaemia
Children
Children & youth
Confidence intervals
Epidemiology
Etiology
Female
Hospitals
Humans
Infant
Infant, Newborn
Interviews
Leukemia
Mothers
Population studies
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Prenatal and postnatal conditions
Regression analysis
Risk analysis
Risk Factors
Sample size
Statistical analysis
São Paulo
Young Adult
title Caesarean sections, prenatal and postnatal conditions and childhood acute lymphoblastic leukaemia: A case-control study in the State of São Paulo, Brazil
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