Tracheal aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia
Objective Extreme preterm infants are a growing population in neonatal intensive care units who carry a high mortality and morbidity. Multiple factors play a role in preterm birth, resulting in major impact on organogenesis leading to complications including bronchopulmonary dysplasia (BPD). The goa...
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| Veröffentlicht in: | Journal of perinatology 2021-03, Vol.41 (3), p.551-561 |
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| creator | Oji-Mmuo, Christiana N. Siddaiah, Roopa Montes, Deborah T. Pham, Melody A. Spear, Debra Donnelly, Ann Fuentes, Nathalie Imamura-Kawasawa, Yuka Howrylak, Judie A. Thomas, Neal J. Silveyra, Patricia |
| description | Objective
Extreme preterm infants are a growing population in neonatal intensive care units who carry a high mortality and morbidity. Multiple factors play a role in preterm birth, resulting in major impact on organogenesis leading to complications including bronchopulmonary dysplasia (BPD). The goal of this study was to identify biomarker signatures associated with prematurity and BPD.
Study design
We analyzed miRNA and mRNA profiles in tracheal aspirates (TAs) from 55 infants receiving invasive mechanical ventilation. Twenty-eight infants were extremely preterm and diagnosed with BPD, and 27 were term babies receiving invasive mechanical ventilation for elective procedures.
Result
We found 22 miRNAs and 33 genes differentially expressed (FDR |
| doi_str_mv | 10.1038/s41372-020-00868-9 |
| format | Article |
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Extreme preterm infants are a growing population in neonatal intensive care units who carry a high mortality and morbidity. Multiple factors play a role in preterm birth, resulting in major impact on organogenesis leading to complications including bronchopulmonary dysplasia (BPD). The goal of this study was to identify biomarker signatures associated with prematurity and BPD.
Study design
We analyzed miRNA and mRNA profiles in tracheal aspirates (TAs) from 55 infants receiving invasive mechanical ventilation. Twenty-eight infants were extremely preterm and diagnosed with BPD, and 27 were term babies receiving invasive mechanical ventilation for elective procedures.
Result
We found 22 miRNAs and 33 genes differentially expressed (FDR < 0.05) in TAs of extreme preterm infants with BPD vs. term babies without BPD. Pathway analysis showed associations with inflammatory response, cellular growth/proliferation, and tissue development.
Conclusions
Specific mRNA-miRNA signatures in TAs may serve as biomarkers for BPD pathogenesis, a consequence of extreme prematurity.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-020-00868-9</identifier><identifier>PMID: 33177681</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>38 ; 38/77 ; 38/90 ; 692/499 ; 692/53/2421 ; Babies ; Biological markers ; Biomarkers ; Birth ; Bronchopulmonary dysplasia ; Complications ; Development and progression ; Diagnosis ; Dysplasia ; Genetic aspects ; Hospitals ; Infants ; Infants (Premature) ; Inflammation ; Inflammatory response ; Intensive care units ; Lung diseases ; Mechanical ventilation ; Medical examination ; Medicine ; Medicine & Public Health ; miRNA ; Morbidity ; Neonates ; Newborn babies ; Organogenesis ; Pathogenesis ; Pediatric research ; Pediatric Surgery ; Pediatrics ; Premature birth ; RNA ; Ventilation ; Ventilators</subject><ispartof>Journal of perinatology, 2021-03, Vol.41 (3), p.551-561</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-5e9a35867838bc068040e1f3b8f0a13e2fd52a489687be40b4e2b09e43ed5ed23</citedby><cites>FETCH-LOGICAL-c517t-5e9a35867838bc068040e1f3b8f0a13e2fd52a489687be40b4e2b09e43ed5ed23</cites><orcidid>0000-0001-9184-3908 ; 0000-0002-8897-9203 ; 0000-0002-2075-4219 ; 0000-0001-7083-8915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-020-00868-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-020-00868-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33177681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oji-Mmuo, Christiana N.</creatorcontrib><creatorcontrib>Siddaiah, Roopa</creatorcontrib><creatorcontrib>Montes, Deborah T.</creatorcontrib><creatorcontrib>Pham, Melody A.</creatorcontrib><creatorcontrib>Spear, Debra</creatorcontrib><creatorcontrib>Donnelly, Ann</creatorcontrib><creatorcontrib>Fuentes, Nathalie</creatorcontrib><creatorcontrib>Imamura-Kawasawa, Yuka</creatorcontrib><creatorcontrib>Howrylak, Judie A.</creatorcontrib><creatorcontrib>Thomas, Neal J.</creatorcontrib><creatorcontrib>Silveyra, Patricia</creatorcontrib><title>Tracheal aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
Extreme preterm infants are a growing population in neonatal intensive care units who carry a high mortality and morbidity. Multiple factors play a role in preterm birth, resulting in major impact on organogenesis leading to complications including bronchopulmonary dysplasia (BPD). The goal of this study was to identify biomarker signatures associated with prematurity and BPD.
Study design
We analyzed miRNA and mRNA profiles in tracheal aspirates (TAs) from 55 infants receiving invasive mechanical ventilation. Twenty-eight infants were extremely preterm and diagnosed with BPD, and 27 were term babies receiving invasive mechanical ventilation for elective procedures.
Result
We found 22 miRNAs and 33 genes differentially expressed (FDR < 0.05) in TAs of extreme preterm infants with BPD vs. term babies without BPD. Pathway analysis showed associations with inflammatory response, cellular growth/proliferation, and tissue development.
Conclusions
Specific mRNA-miRNA signatures in TAs may serve as biomarkers for BPD pathogenesis, a consequence of extreme prematurity.</description><subject>38</subject><subject>38/77</subject><subject>38/90</subject><subject>692/499</subject><subject>692/53/2421</subject><subject>Babies</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Birth</subject><subject>Bronchopulmonary dysplasia</subject><subject>Complications</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Dysplasia</subject><subject>Genetic aspects</subject><subject>Hospitals</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Intensive care units</subject><subject>Lung diseases</subject><subject>Mechanical ventilation</subject><subject>Medical examination</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>miRNA</subject><subject>Morbidity</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Organogenesis</subject><subject>Pathogenesis</subject><subject>Pediatric research</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature birth</subject><subject>RNA</subject><subject>Ventilation</subject><subject>Ventilators</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl1rFTEQhoMo9lj9A15IQBBvtk422SR7eSh-QVGQeh2yu7PnpOwma5JF--_N6anWikhgAjPPDJk3LyHPGZwx4PpNEoyruoIaKgAtddU-IBsmlKyaRvCHZANK8EpzIU_Ik5SuAA5F9ZiccM6UkpptyHIZbb9HO1GbFhdtRpqj9amPbslhdj21fqCz-_JpS5PbeZvXiImGkeKPHHFGupR4k6Wdi3lPv7sSuhh8vw_LOs3B23hNh-u0TDY5-5Q8Gu2U8NntfUq-vnt7ef6huvj8_uP59qLqG6Zy1WBreaOl0lx3PUgNApCNvNMjWMaxHoemtkK3UqsOBXQC6w5aFByHBoean5LXx7lLDN9WTNnMLvU4TdZjWJOphSyiMaVZQV_-hV6FNfryukK1rQCQUtxROzuhcX4MRaj-MNRsZdMoJrmAQp39gypnwCJm8Di6kr_X8OqPhsNP5H0K05pd8Ok-WB_BPoaUIo5miW4u2hoG5uAHc_SDKX4wN34wbWl6cbva2s04_G75ZYAC8COQSsnvMN7t_p-xPwFwK7-F</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Oji-Mmuo, Christiana N.</creator><creator>Siddaiah, Roopa</creator><creator>Montes, Deborah T.</creator><creator>Pham, Melody A.</creator><creator>Spear, Debra</creator><creator>Donnelly, Ann</creator><creator>Fuentes, Nathalie</creator><creator>Imamura-Kawasawa, Yuka</creator><creator>Howrylak, Judie A.</creator><creator>Thomas, Neal J.</creator><creator>Silveyra, Patricia</creator><general>Nature Publishing Group US</general><general>Nature Publishing 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aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia</title><author>Oji-Mmuo, Christiana N. ; Siddaiah, Roopa ; Montes, Deborah T. ; Pham, Melody A. ; Spear, Debra ; Donnelly, Ann ; Fuentes, Nathalie ; Imamura-Kawasawa, Yuka ; Howrylak, Judie A. ; Thomas, Neal J. ; Silveyra, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-5e9a35867838bc068040e1f3b8f0a13e2fd52a489687be40b4e2b09e43ed5ed23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>38</topic><topic>38/77</topic><topic>38/90</topic><topic>692/499</topic><topic>692/53/2421</topic><topic>Babies</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Birth</topic><topic>Bronchopulmonary dysplasia</topic><topic>Complications</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Dysplasia</topic><topic>Genetic aspects</topic><topic>Hospitals</topic><topic>Infants</topic><topic>Infants (Premature)</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Intensive care units</topic><topic>Lung diseases</topic><topic>Mechanical ventilation</topic><topic>Medical examination</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>miRNA</topic><topic>Morbidity</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Organogenesis</topic><topic>Pathogenesis</topic><topic>Pediatric research</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature birth</topic><topic>RNA</topic><topic>Ventilation</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oji-Mmuo, Christiana N.</creatorcontrib><creatorcontrib>Siddaiah, Roopa</creatorcontrib><creatorcontrib>Montes, Deborah T.</creatorcontrib><creatorcontrib>Pham, Melody A.</creatorcontrib><creatorcontrib>Spear, Debra</creatorcontrib><creatorcontrib>Donnelly, Ann</creatorcontrib><creatorcontrib>Fuentes, Nathalie</creatorcontrib><creatorcontrib>Imamura-Kawasawa, Yuka</creatorcontrib><creatorcontrib>Howrylak, Judie A.</creatorcontrib><creatorcontrib>Thomas, Neal J.</creatorcontrib><creatorcontrib>Silveyra, Patricia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma 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Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oji-Mmuo, Christiana N.</au><au>Siddaiah, Roopa</au><au>Montes, Deborah T.</au><au>Pham, Melody A.</au><au>Spear, Debra</au><au>Donnelly, Ann</au><au>Fuentes, Nathalie</au><au>Imamura-Kawasawa, Yuka</au><au>Howrylak, Judie A.</au><au>Thomas, Neal J.</au><au>Silveyra, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tracheal aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>41</volume><issue>3</issue><spage>551</spage><epage>561</epage><pages>551-561</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
Extreme preterm infants are a growing population in neonatal intensive care units who carry a high mortality and morbidity. Multiple factors play a role in preterm birth, resulting in major impact on organogenesis leading to complications including bronchopulmonary dysplasia (BPD). The goal of this study was to identify biomarker signatures associated with prematurity and BPD.
Study design
We analyzed miRNA and mRNA profiles in tracheal aspirates (TAs) from 55 infants receiving invasive mechanical ventilation. Twenty-eight infants were extremely preterm and diagnosed with BPD, and 27 were term babies receiving invasive mechanical ventilation for elective procedures.
Result
We found 22 miRNAs and 33 genes differentially expressed (FDR < 0.05) in TAs of extreme preterm infants with BPD vs. term babies without BPD. Pathway analysis showed associations with inflammatory response, cellular growth/proliferation, and tissue development.
Conclusions
Specific mRNA-miRNA signatures in TAs may serve as biomarkers for BPD pathogenesis, a consequence of extreme prematurity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>33177681</pmid><doi>10.1038/s41372-020-00868-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9184-3908</orcidid><orcidid>https://orcid.org/0000-0002-8897-9203</orcidid><orcidid>https://orcid.org/0000-0002-2075-4219</orcidid><orcidid>https://orcid.org/0000-0001-7083-8915</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of perinatology, 2021-03, Vol.41 (3), p.551-561 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | 38 38/77 38/90 692/499 692/53/2421 Babies Biological markers Biomarkers Birth Bronchopulmonary dysplasia Complications Development and progression Diagnosis Dysplasia Genetic aspects Hospitals Infants Infants (Premature) Inflammation Inflammatory response Intensive care units Lung diseases Mechanical ventilation Medical examination Medicine Medicine & Public Health miRNA Morbidity Neonates Newborn babies Organogenesis Pathogenesis Pediatric research Pediatric Surgery Pediatrics Premature birth RNA Ventilation Ventilators |
| title | Tracheal aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia |
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