Feasibility and accuracy of cord blood sampling for admission laboratory investigations: A pilot trial
Aim Phlebotomy losses greatly contribute to anaemia following preterm birth. Therefore, the possibility of drawing initial tests from the placenta seems attractive. There is a lack of literature regarding the feasibility and accuracy of pathology tests taken from umbilical arterial and venous (UAB/U...
Gespeichert in:
| Veröffentlicht in: | Journal of paediatrics and child health 2021-05, Vol.57 (5), p.611-617 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 617 |
|---|---|
| container_issue | 5 |
| container_start_page | 611 |
| container_title | Journal of paediatrics and child health |
| container_volume | 57 |
| creator | Medeiros, Poliana De B Stark, Michael Long, Miriam Allen, Elizabeth Grace, Erin Andersen, Chad |
| description | Aim
Phlebotomy losses greatly contribute to anaemia following preterm birth. Therefore, the possibility of drawing initial tests from the placenta seems attractive. There is a lack of literature regarding the feasibility and accuracy of pathology tests taken from umbilical arterial and venous (UAB/UVB) compared to blood collected from the newborn.
Methods
UAB and UVB complete blood pictures were compared with the initial neonatal blood test. The relationship between UAB, UVB and neonatal complete blood picture values was determined by Spearman's Rho correlation with absolute values compared by Kruskal‐Wallis. P |
| doi_str_mv | 10.1111/jpc.15273 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2459625331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2522958772</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3533-2720ed2b3a290072460f9cb467f95352ab301511b905497f5a136bdcf11e71bd3</originalsourceid><addsrcrecordid>eNp1kE1LHTEUhkOp1I920T8ggW7qYjQnH5M73cmlakXQRbsOSSaRXHInYzKjzL83eq2LQrM5gfPwnJcXoa9ATqG-s81oT0FQyT6gA-CcNCAF_1j_hPGGr4Dso8NSNoQQKsTqE9pnDCQI1h4gf-F0CSbEMC1YDz3W1s5Z2wUnj23KPTYxpR4XvR1jGO6xTxnrfhtKCWnAUZuU9ZTygsPw6MoU7vVUF-UHPsdjiGnCUw46fkZ7XsfivrzNI_Tn4ufv9VVzc3v5a31-01gmGGuopMT11DBNO0Ik5S3xnTW8lb4TTFBtGAEBYDoieCe90MBa01sP4CSYnh2h7zvvmNPDXPOomtS6GPXg0lwU5aJraT0FFf32D7pJcx5qOkUFpZ1YSUkrdbKjbE6lZOfVmMNW50UBUS_lq1q-ei2_ssdvxtlsXf9O_m27Amc74ClEt_zfpK7v1jvlMwLcjSs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2522958772</pqid></control><display><type>article</type><title>Feasibility and accuracy of cord blood sampling for admission laboratory investigations: A pilot trial</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Medeiros, Poliana De B ; Stark, Michael ; Long, Miriam ; Allen, Elizabeth ; Grace, Erin ; Andersen, Chad</creator><creatorcontrib>Medeiros, Poliana De B ; Stark, Michael ; Long, Miriam ; Allen, Elizabeth ; Grace, Erin ; Andersen, Chad</creatorcontrib><description>Aim
Phlebotomy losses greatly contribute to anaemia following preterm birth. Therefore, the possibility of drawing initial tests from the placenta seems attractive. There is a lack of literature regarding the feasibility and accuracy of pathology tests taken from umbilical arterial and venous (UAB/UVB) compared to blood collected from the newborn.
Methods
UAB and UVB complete blood pictures were compared with the initial neonatal blood test. The relationship between UAB, UVB and neonatal complete blood picture values was determined by Spearman's Rho correlation with absolute values compared by Kruskal‐Wallis. P < 0.05 was considered significant.
Results
Neonatal haemoglobin, white cell count, immature/total ratio and platelets were significantly correlated to the corresponding values in the UAB and UVB (all P < 0.001). While UAB and UVB haemoglobin and white cell count were similar, both were significantly lower than the neonatal values (P < 0.001 and P = 0.014, respectively). No difference was seen for immature/total ratio and platelet concentrations. UVB blood culture (BC) was feasible (90%), even with delayed cord clamping, and the UVB BC volume was significantly higher (P < 0.001), with a low rate of BC contamination (1.5%).
Conclusions
Our findings support the feasibility and accuracy of umbilical blood in place of blood collected from the newborn. This reduces the phlebotomy losses and allows higher blood volume collection which may increase the sensitivity of BC collection.</description><identifier>ISSN: 1034-4810</identifier><identifier>EISSN: 1440-1754</identifier><identifier>DOI: 10.1111/jpc.15273</identifier><identifier>PMID: 33171536</identifier><language>eng</language><publisher>Australia: John Wiley & Sons Australia, Ltd</publisher><subject>Accuracy ; Blood ; Blood tests ; haematology ; Hemoglobin ; infectious disease ; Medical laboratories ; microbiology ; neonatology ; Pediatrics ; Phlebotomy ; Placenta ; Premature babies</subject><ispartof>Journal of paediatrics and child health, 2021-05, Vol.57 (5), p.611-617</ispartof><rights>2020 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)</rights><rights>2020 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).</rights><rights>2021 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-2720ed2b3a290072460f9cb467f95352ab301511b905497f5a136bdcf11e71bd3</citedby><cites>FETCH-LOGICAL-c3533-2720ed2b3a290072460f9cb467f95352ab301511b905497f5a136bdcf11e71bd3</cites><orcidid>0000-0001-7412-6624 ; 0000-0003-1835-8679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjpc.15273$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjpc.15273$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33171536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Medeiros, Poliana De B</creatorcontrib><creatorcontrib>Stark, Michael</creatorcontrib><creatorcontrib>Long, Miriam</creatorcontrib><creatorcontrib>Allen, Elizabeth</creatorcontrib><creatorcontrib>Grace, Erin</creatorcontrib><creatorcontrib>Andersen, Chad</creatorcontrib><title>Feasibility and accuracy of cord blood sampling for admission laboratory investigations: A pilot trial</title><title>Journal of paediatrics and child health</title><addtitle>J Paediatr Child Health</addtitle><description>Aim
Phlebotomy losses greatly contribute to anaemia following preterm birth. Therefore, the possibility of drawing initial tests from the placenta seems attractive. There is a lack of literature regarding the feasibility and accuracy of pathology tests taken from umbilical arterial and venous (UAB/UVB) compared to blood collected from the newborn.
Methods
UAB and UVB complete blood pictures were compared with the initial neonatal blood test. The relationship between UAB, UVB and neonatal complete blood picture values was determined by Spearman's Rho correlation with absolute values compared by Kruskal‐Wallis. P < 0.05 was considered significant.
Results
Neonatal haemoglobin, white cell count, immature/total ratio and platelets were significantly correlated to the corresponding values in the UAB and UVB (all P < 0.001). While UAB and UVB haemoglobin and white cell count were similar, both were significantly lower than the neonatal values (P < 0.001 and P = 0.014, respectively). No difference was seen for immature/total ratio and platelet concentrations. UVB blood culture (BC) was feasible (90%), even with delayed cord clamping, and the UVB BC volume was significantly higher (P < 0.001), with a low rate of BC contamination (1.5%).
Conclusions
Our findings support the feasibility and accuracy of umbilical blood in place of blood collected from the newborn. This reduces the phlebotomy losses and allows higher blood volume collection which may increase the sensitivity of BC collection.</description><subject>Accuracy</subject><subject>Blood</subject><subject>Blood tests</subject><subject>haematology</subject><subject>Hemoglobin</subject><subject>infectious disease</subject><subject>Medical laboratories</subject><subject>microbiology</subject><subject>neonatology</subject><subject>Pediatrics</subject><subject>Phlebotomy</subject><subject>Placenta</subject><subject>Premature babies</subject><issn>1034-4810</issn><issn>1440-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LHTEUhkOp1I920T8ggW7qYjQnH5M73cmlakXQRbsOSSaRXHInYzKjzL83eq2LQrM5gfPwnJcXoa9ATqG-s81oT0FQyT6gA-CcNCAF_1j_hPGGr4Dso8NSNoQQKsTqE9pnDCQI1h4gf-F0CSbEMC1YDz3W1s5Z2wUnj23KPTYxpR4XvR1jGO6xTxnrfhtKCWnAUZuU9ZTygsPw6MoU7vVUF-UHPsdjiGnCUw46fkZ7XsfivrzNI_Tn4ufv9VVzc3v5a31-01gmGGuopMT11DBNO0Ik5S3xnTW8lb4TTFBtGAEBYDoieCe90MBa01sP4CSYnh2h7zvvmNPDXPOomtS6GPXg0lwU5aJraT0FFf32D7pJcx5qOkUFpZ1YSUkrdbKjbE6lZOfVmMNW50UBUS_lq1q-ei2_ssdvxtlsXf9O_m27Amc74ClEt_zfpK7v1jvlMwLcjSs</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Medeiros, Poliana De B</creator><creator>Stark, Michael</creator><creator>Long, Miriam</creator><creator>Allen, Elizabeth</creator><creator>Grace, Erin</creator><creator>Andersen, Chad</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7412-6624</orcidid><orcidid>https://orcid.org/0000-0003-1835-8679</orcidid></search><sort><creationdate>202105</creationdate><title>Feasibility and accuracy of cord blood sampling for admission laboratory investigations: A pilot trial</title><author>Medeiros, Poliana De B ; Stark, Michael ; Long, Miriam ; Allen, Elizabeth ; Grace, Erin ; Andersen, Chad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-2720ed2b3a290072460f9cb467f95352ab301511b905497f5a136bdcf11e71bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Accuracy</topic><topic>Blood</topic><topic>Blood tests</topic><topic>haematology</topic><topic>Hemoglobin</topic><topic>infectious disease</topic><topic>Medical laboratories</topic><topic>microbiology</topic><topic>neonatology</topic><topic>Pediatrics</topic><topic>Phlebotomy</topic><topic>Placenta</topic><topic>Premature babies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medeiros, Poliana De B</creatorcontrib><creatorcontrib>Stark, Michael</creatorcontrib><creatorcontrib>Long, Miriam</creatorcontrib><creatorcontrib>Allen, Elizabeth</creatorcontrib><creatorcontrib>Grace, Erin</creatorcontrib><creatorcontrib>Andersen, Chad</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of paediatrics and child health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medeiros, Poliana De B</au><au>Stark, Michael</au><au>Long, Miriam</au><au>Allen, Elizabeth</au><au>Grace, Erin</au><au>Andersen, Chad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility and accuracy of cord blood sampling for admission laboratory investigations: A pilot trial</atitle><jtitle>Journal of paediatrics and child health</jtitle><addtitle>J Paediatr Child Health</addtitle><date>2021-05</date><risdate>2021</risdate><volume>57</volume><issue>5</issue><spage>611</spage><epage>617</epage><pages>611-617</pages><issn>1034-4810</issn><eissn>1440-1754</eissn><abstract>Aim
Phlebotomy losses greatly contribute to anaemia following preterm birth. Therefore, the possibility of drawing initial tests from the placenta seems attractive. There is a lack of literature regarding the feasibility and accuracy of pathology tests taken from umbilical arterial and venous (UAB/UVB) compared to blood collected from the newborn.
Methods
UAB and UVB complete blood pictures were compared with the initial neonatal blood test. The relationship between UAB, UVB and neonatal complete blood picture values was determined by Spearman's Rho correlation with absolute values compared by Kruskal‐Wallis. P < 0.05 was considered significant.
Results
Neonatal haemoglobin, white cell count, immature/total ratio and platelets were significantly correlated to the corresponding values in the UAB and UVB (all P < 0.001). While UAB and UVB haemoglobin and white cell count were similar, both were significantly lower than the neonatal values (P < 0.001 and P = 0.014, respectively). No difference was seen for immature/total ratio and platelet concentrations. UVB blood culture (BC) was feasible (90%), even with delayed cord clamping, and the UVB BC volume was significantly higher (P < 0.001), with a low rate of BC contamination (1.5%).
Conclusions
Our findings support the feasibility and accuracy of umbilical blood in place of blood collected from the newborn. This reduces the phlebotomy losses and allows higher blood volume collection which may increase the sensitivity of BC collection.</abstract><cop>Australia</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33171536</pmid><doi>10.1111/jpc.15273</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7412-6624</orcidid><orcidid>https://orcid.org/0000-0003-1835-8679</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1034-4810 |
| ispartof | Journal of paediatrics and child health, 2021-05, Vol.57 (5), p.611-617 |
| issn | 1034-4810 1440-1754 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2459625331 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Accuracy Blood Blood tests haematology Hemoglobin infectious disease Medical laboratories microbiology neonatology Pediatrics Phlebotomy Placenta Premature babies |
| title | Feasibility and accuracy of cord blood sampling for admission laboratory investigations: A pilot trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T02%3A01%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feasibility%20and%20accuracy%20of%20cord%20blood%20sampling%20for%20admission%20laboratory%20investigations:%20A%20pilot%20trial&rft.jtitle=Journal%20of%20paediatrics%20and%20child%20health&rft.au=Medeiros,%20Poliana%20De%20B&rft.date=2021-05&rft.volume=57&rft.issue=5&rft.spage=611&rft.epage=617&rft.pages=611-617&rft.issn=1034-4810&rft.eissn=1440-1754&rft_id=info:doi/10.1111/jpc.15273&rft_dat=%3Cproquest_cross%3E2522958772%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2522958772&rft_id=info:pmid/33171536&rfr_iscdi=true |