Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis

Neutrophil infiltration, pro-inflammatory cytokines, and reactive oxygen species (ROS) production have been implicated in development and progression of ulcerative colitis (UC), an inflammatory bowel disease (IBD) characterized by ulcerating inflammation of the mucosal layer generally restricted to...

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Veröffentlicht in:	Chemico-biological interactions 2021-01, Vol.333, p.109315-109315, Article 109315
Hauptverfasser:	Guazelli, Carla F.S., Fattori, Victor, Ferraz, Camila R., Borghi, Sergio M., Casagrande, Rubia, Baracat, Marcela M., Verri, Waldiceu A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - pharmacology Antioxidants - therapeutic use Chalcones - pharmacology Chalcones - therapeutic use Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Colitis, Ulcerative - immunology Colitis, Ulcerative - metabolism Colon - drug effects Colon - pathology Cytokines - biosynthesis Disease Models, Animal Edema - complications Hesperidin - analogs & derivatives Hesperidin - pharmacology Hesperidin - therapeutic use Hesperidin methyl chalcone Inflammation Male Mice Neutrophil Infiltration - drug effects NF-kappa B - metabolism Oxidative stress Oxidative Stress - drug effects Ulcerative colitis
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