Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway

Lung cancer is the major cause of cancer-associated death worldwide, and development of new therapeutic drugs is needed to improve treatment outcomes. Three-dimensional (3D) tumorspheroids offer many advantages over conventional two-dimensional cell cultures due to the similarities to in vivo tumors...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2020-11, Vol.10 (11), p.1521, Article 1521
Hauptverfasser:	Lee, Ji Hae, Park, So-Young, Hwang, Wonbin, Sung, Jee Young, Cho, Myoung-Lae, Shim, Jaegal, Kim, Yong-Nyun, Yoon, Kyungsil
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Alkaloids Animals apoptosis Apoptosis - drug effects Biochemistry & Molecular Biology Caenorhabditis elegans - drug effects Caenorhabditis elegans - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation - drug effects Cephalotaxus - chemistry Harringtonines - pharmacology Health aspects Humans isoharringtonine Life Sciences & Biomedicine Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice NR4A1 NSCLC Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Physiological aspects Science & Technology Signal Transduction - drug effects tumorspheroids Xenograft Model Antitumor Assays
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