Relationships between the vascular structure and neural function of the macula in patients with diabetes mellitus
Purpose To determine the significance of the correlation between the vascular structure and neural function of the macula in patients with diabetes mellitus. Study design Single-center observational study. Patients and methods Ninety eyes of 90 diabetic patients with an average (SD) age of 63.5 (3.8...
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Veröffentlicht in: | Japanese journal of ophthalmology 2021, Vol.65 (1), p.77-88 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose
To determine the significance of the correlation between the vascular structure and neural function of the macula in patients with diabetes mellitus.
Study design
Single-center observational study.
Patients and methods
Ninety eyes of 90 diabetic patients with an average (SD) age of 63.5 (3.8) years were studied. Fifty of the eyes had no clinically apparent diabetic retinopathy (non-DR), and 40 eyes had mild-to-moderate nonproliferative DR (NPDR). Thirty age-matched healthy individuals were also studied in the same way. Swept-source optical coherence tomography angiography (OCTA) was performed to obtain 3 × 3-mm en face images of the posterior pole of the eye. The vascular densities (VDs) of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) were determined. The focal macular electroretinograms (ERGs) elicited by a 15° circular stimulus centered on the fovea were recorded. The amplitudes of the a- and b-waves, sum of the oscillatory potentials (ΣOPs), photopic negative response (PhNR), and implicit times of the individual OPs (OP1-OP3) were measured.
Results
The VDs of the SCP and DCP were reduced in eyes with advanced DR (
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ISSN: | 0021-5155 1613-2246 |
DOI: | 10.1007/s10384-020-00784-7 |