Selenium status in a Northern Irish pregnant cohort with iodine deficiency
Selenium and iodine are trace elements that are maximally concentrated in the thyroid. Iodine is a substrate for thyroid hormone synthesis, while the selenoproteins protect the thyroid from the oxidative stress incurred. We measured plasma selenium concentration in 241 pregnant women in 1st trimeste...
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| Veröffentlicht in: | European journal of clinical nutrition 2021-02, Vol.75 (2), p.403-405 |
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| creator | Mullan, K. R. McMullan, P. Hunter, A. McCance, D. R. Smyth, P. Bath, S. C. Rayman, M. Woodside, J. V. |
| description | Selenium and iodine are trace elements that are maximally concentrated in the thyroid. Iodine is a substrate for thyroid hormone synthesis, while the selenoproteins protect the thyroid from the oxidative stress incurred. We measured plasma selenium concentration in 241 pregnant women in 1st trimester, previously reported to have iodine deficiency. Mean age was 30.3 years (SD 5.4), BMI 26.2 kg/m
2
(SD 4.9) and 53% reported taking supplements. Median urinary iodine concentration was 73 μg/L (IQR 37–122) (WHO recommendation, ≥150 μg/L). Mean plasma selenium concentration was 75 µg/L (SD 7.7) which is below the 80–125 µg/L reported to be optimal. Four-day food diaries revealed a selenium intake of 43 µg/day (SD 15.9), also below the 55–70 µg/day reported to be optimal. This is the first report of selenium status in pregnancy on the island of Ireland. The possible combined effects of iodine and selenium deficiencies in pregnancy merit further investigation. |
| doi_str_mv | 10.1038/s41430-020-00721-4 |
| format | Article |
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2
(SD 4.9) and 53% reported taking supplements. Median urinary iodine concentration was 73 μg/L (IQR 37–122) (WHO recommendation, ≥150 μg/L). Mean plasma selenium concentration was 75 µg/L (SD 7.7) which is below the 80–125 µg/L reported to be optimal. Four-day food diaries revealed a selenium intake of 43 µg/day (SD 15.9), also below the 55–70 µg/day reported to be optimal. This is the first report of selenium status in pregnancy on the island of Ireland. The possible combined effects of iodine and selenium deficiencies in pregnancy merit further investigation.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-020-00721-4</identifier><identifier>PMID: 33168959</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/58 ; 631/45/776/1180 ; 692/699/1702/295 ; Brief Communication ; Clinical Nutrition ; Complications and side effects ; Diaries ; Dietary supplements ; Epidemiology ; Health aspects ; Internal Medicine ; Iodine ; Iodine deficiency diseases ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nutrient deficiency ; Oxidative stress ; Pregnancy ; Pregnant women ; Public Health ; Selenium ; Selenoproteins ; Substrates ; Thyroid ; Thyroid gland ; Trace elements</subject><ispartof>European journal of clinical nutrition, 2021-02, Vol.75 (2), p.403-405</ispartof><rights>Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-43b0f9a1db65791d7a8a0a8e7e78a067efffdcdcfb724d275ab5f9d1211467d43</citedby><cites>FETCH-LOGICAL-c555t-43b0f9a1db65791d7a8a0a8e7e78a067efffdcdcfb724d275ab5f9d1211467d43</cites><orcidid>0000-0003-3126-5709 ; 0000-0002-5691-4659 ; 0000-0002-6355-1964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41430-020-00721-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41430-020-00721-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33168959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mullan, K. R.</creatorcontrib><creatorcontrib>McMullan, P.</creatorcontrib><creatorcontrib>Hunter, A.</creatorcontrib><creatorcontrib>McCance, D. R.</creatorcontrib><creatorcontrib>Smyth, P.</creatorcontrib><creatorcontrib>Bath, S. C.</creatorcontrib><creatorcontrib>Rayman, M.</creatorcontrib><creatorcontrib>Woodside, J. V.</creatorcontrib><title>Selenium status in a Northern Irish pregnant cohort with iodine deficiency</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Selenium and iodine are trace elements that are maximally concentrated in the thyroid. Iodine is a substrate for thyroid hormone synthesis, while the selenoproteins protect the thyroid from the oxidative stress incurred. We measured plasma selenium concentration in 241 pregnant women in 1st trimester, previously reported to have iodine deficiency. Mean age was 30.3 years (SD 5.4), BMI 26.2 kg/m
2
(SD 4.9) and 53% reported taking supplements. Median urinary iodine concentration was 73 μg/L (IQR 37–122) (WHO recommendation, ≥150 μg/L). Mean plasma selenium concentration was 75 µg/L (SD 7.7) which is below the 80–125 µg/L reported to be optimal. Four-day food diaries revealed a selenium intake of 43 µg/day (SD 15.9), also below the 55–70 µg/day reported to be optimal. This is the first report of selenium status in pregnancy on the island of Ireland. 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2
(SD 4.9) and 53% reported taking supplements. Median urinary iodine concentration was 73 μg/L (IQR 37–122) (WHO recommendation, ≥150 μg/L). Mean plasma selenium concentration was 75 µg/L (SD 7.7) which is below the 80–125 µg/L reported to be optimal. Four-day food diaries revealed a selenium intake of 43 µg/day (SD 15.9), also below the 55–70 µg/day reported to be optimal. This is the first report of selenium status in pregnancy on the island of Ireland. The possible combined effects of iodine and selenium deficiencies in pregnancy merit further investigation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33168959</pmid><doi>10.1038/s41430-020-00721-4</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-3126-5709</orcidid><orcidid>https://orcid.org/0000-0002-5691-4659</orcidid><orcidid>https://orcid.org/0000-0002-6355-1964</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 101/58 631/45/776/1180 692/699/1702/295 Brief Communication Clinical Nutrition Complications and side effects Diaries Dietary supplements Epidemiology Health aspects Internal Medicine Iodine Iodine deficiency diseases Medicine Medicine & Public Health Metabolic Diseases Nutrient deficiency Oxidative stress Pregnancy Pregnant women Public Health Selenium Selenoproteins Substrates Thyroid Thyroid gland Trace elements |
| title | Selenium status in a Northern Irish pregnant cohort with iodine deficiency |
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