Olfactory dysfunction in essential tremor versus tremor dominant Parkinson disease
•Essential tremor and tremor dominant Parkinson disease variant constitute the main causes of geriatric tremor.•Olfactory dysfunction is a consistent non-motor manifestations (NMM) of PD and and additional sign in ET patients.•Sniffin’ Sticks test as well as Olfactory bulb volume are valuable biomar...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2021-01, Vol.200, p.106352-106352, Article 106352 |
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| creator | Elhassanien, Mahmoud Ebrahim Mostafa Bahnasy, Wafik Said El-Heneedy, Yasser Abo Elfotoh Kishk, Ahmed Mustafa Tomoum, Mohamed Osama Ramadan, Kareem Mohammed Allah Ragab, Osama Abd |
| description | •Essential tremor and tremor dominant Parkinson disease variant constitute the main causes of geriatric tremor.•Olfactory dysfunction is a consistent non-motor manifestations (NMM) of PD and and additional sign in ET patients.•Sniffin’ Sticks test as well as Olfactory bulb volume are valuable biomarkers that differentiate doubtful TDPD and ET cases.
Essential tremor (ET) and tremor dominant Parkinson disease (TDPD) variant constitute the main causes of geriatric tremor which differentiation is not always an easy mission. The objective of this work was to study the olfactory performance in ET and PD patients for possible consideration as a differentiating biomarker.
This study was performed on 36ET, 22 TDPD variant and 24 healthy controls subjects (HCS) submitted to extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV).
There were significant decreases in SST threshold, discrimination, identification and TDI variables in TDPD patients compared to ET and HCS. ET patients showed significant decrease in the same variables compared to HCS. Regarding OBV, there were significant decreases in TDPD patients compared to ET and HCS with nonsignificant difference between the 2-latter groups. Our results showed that TDI score of 25 can differentiate between TDPD and ET patients with sensitivity and specificity (94 %, 91 %) respectively.
Olfactory assessment is a rapid, safe, and easily applicable biomarker that could differentiate TDPD from ET in doubtful cases. |
| doi_str_mv | 10.1016/j.clineuro.2020.106352 |
| format | Article |
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Essential tremor (ET) and tremor dominant Parkinson disease (TDPD) variant constitute the main causes of geriatric tremor which differentiation is not always an easy mission. The objective of this work was to study the olfactory performance in ET and PD patients for possible consideration as a differentiating biomarker.
This study was performed on 36ET, 22 TDPD variant and 24 healthy controls subjects (HCS) submitted to extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV).
There were significant decreases in SST threshold, discrimination, identification and TDI variables in TDPD patients compared to ET and HCS. ET patients showed significant decrease in the same variables compared to HCS. Regarding OBV, there were significant decreases in TDPD patients compared to ET and HCS with nonsignificant difference between the 2-latter groups. Our results showed that TDI score of 25 can differentiate between TDPD and ET patients with sensitivity and specificity (94 %, 91 %) respectively.
Olfactory assessment is a rapid, safe, and easily applicable biomarker that could differentiate TDPD from ET in doubtful cases.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2020.106352</identifier><identifier>PMID: 33168334</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Asymmetry ; Biomarkers ; Butanol ; Essential tremors ; Family medical history ; Identification ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Olfaction ; Olfaction disorders ; Olfactory bulb ; Olfactory bulb volumetry ; Olfactory discrimination ; Olfactory discrimination learning ; Parkinson's disease ; Sniffin’ sticks test ; Tremor ; Tremor (Muscular contraction) ; Tremor dominant Parkinson disease ; Variables</subject><ispartof>Clinical neurology and neurosurgery, 2021-01, Vol.200, p.106352-106352, Article 106352</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>2020. Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-89672009fcc9ac9b1d3dbb0e31ccd1e92706e22eefc66b3c67c5787d86b9d35a3</citedby><cites>FETCH-LOGICAL-c396t-89672009fcc9ac9b1d3dbb0e31ccd1e92706e22eefc66b3c67c5787d86b9d35a3</cites><orcidid>0000-0001-5544-3958 ; 0000-0003-0215-7629</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0303846720306958$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33168334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elhassanien, Mahmoud Ebrahim Mostafa</creatorcontrib><creatorcontrib>Bahnasy, Wafik Said</creatorcontrib><creatorcontrib>El-Heneedy, Yasser Abo Elfotoh</creatorcontrib><creatorcontrib>Kishk, Ahmed Mustafa</creatorcontrib><creatorcontrib>Tomoum, Mohamed Osama</creatorcontrib><creatorcontrib>Ramadan, Kareem Mohammed</creatorcontrib><creatorcontrib>Allah Ragab, Osama Abd</creatorcontrib><title>Olfactory dysfunction in essential tremor versus tremor dominant Parkinson disease</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>•Essential tremor and tremor dominant Parkinson disease variant constitute the main causes of geriatric tremor.•Olfactory dysfunction is a consistent non-motor manifestations (NMM) of PD and and additional sign in ET patients.•Sniffin’ Sticks test as well as Olfactory bulb volume are valuable biomarkers that differentiate doubtful TDPD and ET cases.
Essential tremor (ET) and tremor dominant Parkinson disease (TDPD) variant constitute the main causes of geriatric tremor which differentiation is not always an easy mission. The objective of this work was to study the olfactory performance in ET and PD patients for possible consideration as a differentiating biomarker.
This study was performed on 36ET, 22 TDPD variant and 24 healthy controls subjects (HCS) submitted to extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV).
There were significant decreases in SST threshold, discrimination, identification and TDI variables in TDPD patients compared to ET and HCS. ET patients showed significant decrease in the same variables compared to HCS. Regarding OBV, there were significant decreases in TDPD patients compared to ET and HCS with nonsignificant difference between the 2-latter groups. Our results showed that TDI score of 25 can differentiate between TDPD and ET patients with sensitivity and specificity (94 %, 91 %) respectively.
Olfactory assessment is a rapid, safe, and easily applicable biomarker that could differentiate TDPD from ET in doubtful cases.</description><subject>Asymmetry</subject><subject>Biomarkers</subject><subject>Butanol</subject><subject>Essential tremors</subject><subject>Family medical history</subject><subject>Identification</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Olfaction</subject><subject>Olfaction disorders</subject><subject>Olfactory bulb</subject><subject>Olfactory bulb volumetry</subject><subject>Olfactory discrimination</subject><subject>Olfactory discrimination learning</subject><subject>Parkinson's disease</subject><subject>Sniffin’ sticks test</subject><subject>Tremor</subject><subject>Tremor (Muscular contraction)</subject><subject>Tremor dominant Parkinson disease</subject><subject>Variables</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1r3DAQhkVoSTZp_kIw9NKLt_qwZenWEtI2EEgp7VnIozFoY0upxg7sv6-XzfbQS09C0vO-MzyM3Qi-FVzoj7stjDHhUvJWcnl41KqVZ2wjTCdrbbV5wzZccVWbRncX7JJoxzlXSptzdqGU0EapZsN-PI6DhzmXfRX2NCwJ5phTFVOFRJjm6MdqLjjlUr1goYVOt5CnmHyaq---PMVEayhEQk_4jr0d_Eh4_XpesV9f7n7efqsfHr_e335-qEFZPdfG6k5ybgcA68H2IqjQ9xyVAAgCrey4RikRB9C6V6A7aDvTBaN7G1Tr1RX7cOx9Lvn3gjS7KRLgOPqEeSEnm9aqxjRdu6Lv_0F3eSlp3W6l1v_GNu2B0kcKSiYqOLjnEidf9k5wd7Dudu5k3R2su6P1NXjzWr_0E4a_sZPmFfh0BHD18RKxOIKICTDEgjC7kOP_ZvwBLCaX7A</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Elhassanien, Mahmoud Ebrahim Mostafa</creator><creator>Bahnasy, Wafik Said</creator><creator>El-Heneedy, Yasser Abo Elfotoh</creator><creator>Kishk, Ahmed Mustafa</creator><creator>Tomoum, Mohamed Osama</creator><creator>Ramadan, Kareem Mohammed</creator><creator>Allah Ragab, Osama Abd</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5544-3958</orcidid><orcidid>https://orcid.org/0000-0003-0215-7629</orcidid></search><sort><creationdate>202101</creationdate><title>Olfactory dysfunction in essential tremor versus tremor dominant Parkinson disease</title><author>Elhassanien, Mahmoud Ebrahim Mostafa ; 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Essential tremor (ET) and tremor dominant Parkinson disease (TDPD) variant constitute the main causes of geriatric tremor which differentiation is not always an easy mission. The objective of this work was to study the olfactory performance in ET and PD patients for possible consideration as a differentiating biomarker.
This study was performed on 36ET, 22 TDPD variant and 24 healthy controls subjects (HCS) submitted to extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV).
There were significant decreases in SST threshold, discrimination, identification and TDI variables in TDPD patients compared to ET and HCS. ET patients showed significant decrease in the same variables compared to HCS. Regarding OBV, there were significant decreases in TDPD patients compared to ET and HCS with nonsignificant difference between the 2-latter groups. Our results showed that TDI score of 25 can differentiate between TDPD and ET patients with sensitivity and specificity (94 %, 91 %) respectively.
Olfactory assessment is a rapid, safe, and easily applicable biomarker that could differentiate TDPD from ET in doubtful cases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33168334</pmid><doi>10.1016/j.clineuro.2020.106352</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5544-3958</orcidid><orcidid>https://orcid.org/0000-0003-0215-7629</orcidid></addata></record> |
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| ispartof | Clinical neurology and neurosurgery, 2021-01, Vol.200, p.106352-106352, Article 106352 |
| issn | 0303-8467 1872-6968 |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Asymmetry Biomarkers Butanol Essential tremors Family medical history Identification Movement disorders Neurodegenerative diseases Neurology Olfaction Olfaction disorders Olfactory bulb Olfactory bulb volumetry Olfactory discrimination Olfactory discrimination learning Parkinson's disease Sniffin’ sticks test Tremor Tremor (Muscular contraction) Tremor dominant Parkinson disease Variables |
| title | Olfactory dysfunction in essential tremor versus tremor dominant Parkinson disease |
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