Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles

Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and signal‐modulating roles. Afadin is a complex modulator of c...

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Veröffentlicht in:	BioEssays 2021-01, Vol.43 (1), p.e2000221-n/a
Hauptverfasser:	Huxham, Jennifer, Tabariès, Sébastien, Siegel, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions afadin Apoptosis Cancer cancer progression Cell Adhesion Cell Polarity Humans Metastases metastasis Microfilament Proteins Neoplasms - genetics Polarity Proteins Scaffolds Signal processing Signal transduction Tight Junctions
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