Arterial function in hypertensive pregnant women. Is arterial stiffness a marker for the outcomes in pregnancy?
Hypertension (HTN) in pregnancy is a major cause of maternal, foetal and neonatal morbimortality in both developing and developed countries. Arterial stiffness is a predictor of cardiovascular events and can be assessed through augmentation index (AIx) and pulse wave velocity (PWV). This study was i...
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| Veröffentlicht in: | Life sciences (1973) 2021-01, Vol.264, p.118723-118723, Article 118723 |
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| creator | Turi, Vladiana Iurciuc, Stela Crețu, Octavian Marius Tit, Delia Mirela Bungau, Simona Apostol, Adrian Moleriu, Radu Dumitru Bustea, Cristiana Behl, Tapan Diaconu, Camelia Cristina Petre, Izabella |
| description | Hypertension (HTN) in pregnancy is a major cause of maternal, foetal and neonatal morbimortality in both developing and developed countries. Arterial stiffness is a predictor of cardiovascular events and can be assessed through augmentation index (AIx) and pulse wave velocity (PWV). This study was intended to analyse the arterial stiffness in three categories, hypertensive pregnant women vs. healthy women (both pregnant and non-pregnant).
Between 2018 and 2019, 150 women were prospectively included into three homogenous groups, of equal sizes (N = 50): pregnant women with HTN (group 1), pregnant women without HTN (group 2), and non-pregnant women (group 3). We assessed pregnant women 3 times (in all three trimesters) and six weeks postpartum, and the women from the control group once.
Significant differences (p |
| doi_str_mv | 10.1016/j.lfs.2020.118723 |
| format | Article |
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Between 2018 and 2019, 150 women were prospectively included into three homogenous groups, of equal sizes (N = 50): pregnant women with HTN (group 1), pregnant women without HTN (group 2), and non-pregnant women (group 3). We assessed pregnant women 3 times (in all three trimesters) and six weeks postpartum, and the women from the control group once.
Significant differences (p < 0.001) of the hemodynamic and arterial stiffness parameters and of the heart rate (HR) (p = 0.006) were observed between groups 1 and 2. Women with pregnancy-induced HTN had different values of arterial function parameters long time before the first signs of high blood pressure (BP) occurred. Also, body mass index (BMI) had a deleterious effect in all patients, but especially in pregnant HTN women. Significant differences (p < 0.001) between groups 2 and 3 were observed regarding the BP and aortic PWV (PWVao) and, as well, significant differences (p < 0.05) between BMI, aortic systolic BP (p = 0.02), brachial AIx (p = 0.01) and pulse pressure (PP) (p = 0.049) values.
The current study emphasizes the importance of the assessment of arterial function parameters and BMI as markers for future BP values and outcomes throughout gestation.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2020.118723</identifier><identifier>PMID: 33160988</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Ankle Brachial Index ; Aorta ; Arterial stiffness ; Blood pressure ; Blood Pressure - physiology ; Body mass ; Body Mass Index ; Body size ; Cardiovascular risk ; Developed countries ; Diastole - physiology ; Female ; Gestation ; Heart rate ; Heart Rate - physiology ; Hemodynamics ; High blood pressure ; Humans ; Hypertension ; Hypertension, Pregnancy-Induced - physiopathology ; Markers ; Neonates ; Parameters ; Postpartum ; Pregnancy ; Pregnancy Outcome ; Pulse Wave Analysis ; Pulse wave velocity ; Stiffness ; Systole - physiology ; Vascular Stiffness - physiology ; Wave velocity</subject><ispartof>Life sciences (1973), 2021-01, Vol.264, p.118723-118723, Article 118723</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier BV Jan 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-1bd610ac44e717c535970acc10a6016635c7df05fc053d4db1559b60651d0b63</citedby><cites>FETCH-LOGICAL-c381t-1bd610ac44e717c535970acc10a6016635c7df05fc053d4db1559b60651d0b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2020.118723$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33160988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turi, Vladiana</creatorcontrib><creatorcontrib>Iurciuc, Stela</creatorcontrib><creatorcontrib>Crețu, Octavian Marius</creatorcontrib><creatorcontrib>Tit, Delia Mirela</creatorcontrib><creatorcontrib>Bungau, Simona</creatorcontrib><creatorcontrib>Apostol, Adrian</creatorcontrib><creatorcontrib>Moleriu, Radu Dumitru</creatorcontrib><creatorcontrib>Bustea, Cristiana</creatorcontrib><creatorcontrib>Behl, Tapan</creatorcontrib><creatorcontrib>Diaconu, Camelia Cristina</creatorcontrib><creatorcontrib>Petre, Izabella</creatorcontrib><title>Arterial function in hypertensive pregnant women. Is arterial stiffness a marker for the outcomes in pregnancy?</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Hypertension (HTN) in pregnancy is a major cause of maternal, foetal and neonatal morbimortality in both developing and developed countries. Arterial stiffness is a predictor of cardiovascular events and can be assessed through augmentation index (AIx) and pulse wave velocity (PWV). This study was intended to analyse the arterial stiffness in three categories, hypertensive pregnant women vs. healthy women (both pregnant and non-pregnant).
Between 2018 and 2019, 150 women were prospectively included into three homogenous groups, of equal sizes (N = 50): pregnant women with HTN (group 1), pregnant women without HTN (group 2), and non-pregnant women (group 3). We assessed pregnant women 3 times (in all three trimesters) and six weeks postpartum, and the women from the control group once.
Significant differences (p < 0.001) of the hemodynamic and arterial stiffness parameters and of the heart rate (HR) (p = 0.006) were observed between groups 1 and 2. Women with pregnancy-induced HTN had different values of arterial function parameters long time before the first signs of high blood pressure (BP) occurred. Also, body mass index (BMI) had a deleterious effect in all patients, but especially in pregnant HTN women. Significant differences (p < 0.001) between groups 2 and 3 were observed regarding the BP and aortic PWV (PWVao) and, as well, significant differences (p < 0.05) between BMI, aortic systolic BP (p = 0.02), brachial AIx (p = 0.01) and pulse pressure (PP) (p = 0.049) values.
The current study emphasizes the importance of the assessment of arterial function parameters and BMI as markers for future BP values and outcomes throughout gestation.</description><subject>Adult</subject><subject>Ankle Brachial Index</subject><subject>Aorta</subject><subject>Arterial stiffness</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Cardiovascular risk</subject><subject>Developed countries</subject><subject>Diastole - physiology</subject><subject>Female</subject><subject>Gestation</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Hemodynamics</subject><subject>High blood pressure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pregnancy-Induced - physiopathology</subject><subject>Markers</subject><subject>Neonates</subject><subject>Parameters</subject><subject>Postpartum</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pulse Wave Analysis</subject><subject>Pulse wave velocity</subject><subject>Stiffness</subject><subject>Systole - physiology</subject><subject>Vascular Stiffness - physiology</subject><subject>Wave velocity</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9P3DAQxS1UVLa0H4ALstRLL1nGduwk6gEh1D9ISL1wtxJnDF6y9mI7i_bb16tdeuDQ02hGv_c0M4-QCwZLBkxdrZaTTUsOvPSsbbg4IYtSuwqUYB_IAoDXleAgz8inlFYAIGUjPpIzIZiCrm0XJNzEjNH1E7WzN9kFT52nT7sNlrlPbot0E_HR9z7T17BGv6R3ifZvopSdtR5TGdF1H58xUhsizU9Iw5xNEaS939HC7K4_k1PbTwm_HOs5efj54-H2d3X_59fd7c19ZUTLcsWGUTHoTV1jwxojheya0poyU-VyJaRpRgvSGpBirMeBSdkNCpRkIwxKnJNvB9tNDC8zpqzXLhmcpt5jmJPmtWw7xZuuLujXd-gqzNGX5TSXIBuuWi4LxQ6UiSGliFZvoisX7zQDvQ9Dr3QJQ-_D0Icwiuby6DwPaxz_Kd6-X4DvBwDLJ7YOo07GoTc4uogm6zG4_9j_BZRfmfI</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Turi, Vladiana</creator><creator>Iurciuc, Stela</creator><creator>Crețu, Octavian Marius</creator><creator>Tit, Delia Mirela</creator><creator>Bungau, Simona</creator><creator>Apostol, Adrian</creator><creator>Moleriu, Radu Dumitru</creator><creator>Bustea, Cristiana</creator><creator>Behl, Tapan</creator><creator>Diaconu, Camelia Cristina</creator><creator>Petre, Izabella</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Arterial function in hypertensive pregnant women. Is arterial stiffness a marker for the outcomes in pregnancy?</title><author>Turi, Vladiana ; Iurciuc, Stela ; Crețu, Octavian Marius ; Tit, Delia Mirela ; Bungau, Simona ; Apostol, Adrian ; Moleriu, Radu Dumitru ; Bustea, Cristiana ; Behl, Tapan ; Diaconu, Camelia Cristina ; Petre, Izabella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-1bd610ac44e717c535970acc10a6016635c7df05fc053d4db1559b60651d0b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Ankle Brachial Index</topic><topic>Aorta</topic><topic>Arterial stiffness</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Cardiovascular risk</topic><topic>Developed countries</topic><topic>Diastole - physiology</topic><topic>Female</topic><topic>Gestation</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Hemodynamics</topic><topic>High blood pressure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pregnancy-Induced - physiopathology</topic><topic>Markers</topic><topic>Neonates</topic><topic>Parameters</topic><topic>Postpartum</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pulse Wave Analysis</topic><topic>Pulse wave velocity</topic><topic>Stiffness</topic><topic>Systole - physiology</topic><topic>Vascular Stiffness - physiology</topic><topic>Wave velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turi, Vladiana</creatorcontrib><creatorcontrib>Iurciuc, Stela</creatorcontrib><creatorcontrib>Crețu, Octavian Marius</creatorcontrib><creatorcontrib>Tit, Delia Mirela</creatorcontrib><creatorcontrib>Bungau, Simona</creatorcontrib><creatorcontrib>Apostol, Adrian</creatorcontrib><creatorcontrib>Moleriu, Radu Dumitru</creatorcontrib><creatorcontrib>Bustea, Cristiana</creatorcontrib><creatorcontrib>Behl, Tapan</creatorcontrib><creatorcontrib>Diaconu, Camelia Cristina</creatorcontrib><creatorcontrib>Petre, Izabella</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turi, Vladiana</au><au>Iurciuc, Stela</au><au>Crețu, Octavian Marius</au><au>Tit, Delia Mirela</au><au>Bungau, Simona</au><au>Apostol, Adrian</au><au>Moleriu, Radu Dumitru</au><au>Bustea, Cristiana</au><au>Behl, Tapan</au><au>Diaconu, Camelia Cristina</au><au>Petre, Izabella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arterial function in hypertensive pregnant women. Is arterial stiffness a marker for the outcomes in pregnancy?</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>264</volume><spage>118723</spage><epage>118723</epage><pages>118723-118723</pages><artnum>118723</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Hypertension (HTN) in pregnancy is a major cause of maternal, foetal and neonatal morbimortality in both developing and developed countries. Arterial stiffness is a predictor of cardiovascular events and can be assessed through augmentation index (AIx) and pulse wave velocity (PWV). This study was intended to analyse the arterial stiffness in three categories, hypertensive pregnant women vs. healthy women (both pregnant and non-pregnant).
Between 2018 and 2019, 150 women were prospectively included into three homogenous groups, of equal sizes (N = 50): pregnant women with HTN (group 1), pregnant women without HTN (group 2), and non-pregnant women (group 3). We assessed pregnant women 3 times (in all three trimesters) and six weeks postpartum, and the women from the control group once.
Significant differences (p < 0.001) of the hemodynamic and arterial stiffness parameters and of the heart rate (HR) (p = 0.006) were observed between groups 1 and 2. Women with pregnancy-induced HTN had different values of arterial function parameters long time before the first signs of high blood pressure (BP) occurred. Also, body mass index (BMI) had a deleterious effect in all patients, but especially in pregnant HTN women. Significant differences (p < 0.001) between groups 2 and 3 were observed regarding the BP and aortic PWV (PWVao) and, as well, significant differences (p < 0.05) between BMI, aortic systolic BP (p = 0.02), brachial AIx (p = 0.01) and pulse pressure (PP) (p = 0.049) values.
The current study emphasizes the importance of the assessment of arterial function parameters and BMI as markers for future BP values and outcomes throughout gestation.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>33160988</pmid><doi>10.1016/j.lfs.2020.118723</doi><tpages>1</tpages></addata></record> |
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| ispartof | Life sciences (1973), 2021-01, Vol.264, p.118723-118723, Article 118723 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Ankle Brachial Index Aorta Arterial stiffness Blood pressure Blood Pressure - physiology Body mass Body Mass Index Body size Cardiovascular risk Developed countries Diastole - physiology Female Gestation Heart rate Heart Rate - physiology Hemodynamics High blood pressure Humans Hypertension Hypertension, Pregnancy-Induced - physiopathology Markers Neonates Parameters Postpartum Pregnancy Pregnancy Outcome Pulse Wave Analysis Pulse wave velocity Stiffness Systole - physiology Vascular Stiffness - physiology Wave velocity |
| title | Arterial function in hypertensive pregnant women. Is arterial stiffness a marker for the outcomes in pregnancy? |
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