The effect of geniposide on chronic unpredictable mild stress‐induced depressive mice through BTK/TLR4/NF‐κB and BDNF/TrkB signaling pathways

The purpose of this study was to estimate the pharmacological effect of geniposide (GEN) on depression, caused by chronic unpredictable mild stress (CUMS), and explore its potential mechanism. During the 6 week CUMS procedure, the mice were treated with GEN (10, 40 mg/kg) by gavage once daily for 3 ...

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Veröffentlicht in:	Phytotherapy research 2021-02, Vol.35 (2), p.932-945
Hauptverfasser:	Chen, Tong, Liu, Shengnan, Zheng, Menglin, Li, Yixuan, He, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BDNF/TrkB pathway Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - drug effects BTK/TLR4/NF‐κB pathway Corticosterone CUMS Cytokines depression Geniposide Inflammation Iridoids - pharmacology Iridoids - therapeutic use Male Mice MyD88 protein NF-kappa B - drug effects PC12 Cells Pheochromocytoma cells Proteins Rats Signal Transduction Signaling Stress, Psychological - drug therapy TLR4 protein Toll-Like Receptor 4 - drug effects Toll-like receptors TrkB receptors
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