A decade of cell death studies: Breathing new life into necroptosis
Programmed cell death (PCD) has been a major area of constantly growing interest over the last three decades. Originally, apoptosis was considered the only mechanistic pathway for PCD, but recently several different pathways (i.e., necroptosis, pyroptosis, ferroptosis) have emerged as important in b...
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| Veröffentlicht in: | Pharmacology & therapeutics (Oxford) 2021-04, Vol.220, p.107717-107717, Article 107717 |
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| container_end_page | 107717 |
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| container_title | Pharmacology & therapeutics (Oxford) |
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| creator | Khan, Imran Yousif, Abdelrahman Chesnokov, Mikhail Hong, Linda Chefetz, IIana |
| description | Programmed cell death (PCD) has been a major area of constantly growing interest over the last three decades. Originally, apoptosis was considered the only mechanistic pathway for PCD, but recently several different pathways (i.e., necroptosis, pyroptosis, ferroptosis) have emerged as important in both normal and pathological conditions.
This review focuses on programmed cell necrosis (i.e., necroptosis) as a promising research direction that will help us in understanding the molecular and cellular processes behind different pathological conditions, such as chronic inflammation, neurodegeneration, and cardiovascular diseases. In addition, we discuss natural and chemical compounds and novel targeted therapies triggering necroptosis to induce cell death in cancer cells to overcome chemoresistance. |
| doi_str_mv | 10.1016/j.pharmthera.2020.107717 |
| format | Article |
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| ispartof | Pharmacology & therapeutics (Oxford), 2021-04, Vol.220, p.107717-107717, Article 107717 |
| issn | 0163-7258 1879-016X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Apoptosis Cancer Cardiovascular disorders Cell Death Cell programmed necrosis Humans MLKL Necroptosis Necrosis Neurodegenerative diseases RIPK1 RIPK3 |
| title | A decade of cell death studies: Breathing new life into necroptosis |
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