Binge‐Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood
Background Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed...
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| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2021-01, Vol.45 (1), p.56-63 |
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| creator | Maia, Cristiane do Socorro Ferraz Queiroz, Letícia Yoshitome Oliveira, Igor Gonçalves Silva, Carla Cristiane Soares Cunha, Rodrigo A. Souza‐Monteiro, Deiweson Ferreira, Maria Karolina Martins Silveira, Felipe Martins Silva, Jordana Conceição Balbinot, Gabriela de Souza Collares, Fabrício Mezzomo Martins, Marco Antônio Trevizani Martins, Manoela Domingues Lima, Rafael Rodrigues |
| description | Background
Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed to investigate the effect of EtOH binge drinking on the alveolar bone and the long‐term consequences after abstinence.
Methods
Adolescent female Wistar rats (35 days old) were exposed to 4 cycles of EtOH binge drinking (3 g/kg/d; 3 days On‐4 days Off) or distilled water (control group). Alveolar bone micromorphology and vertical bone distance were evaluated at 1, 30, and 60 days after that last EtOH intake through X‐ray computed microtomography. The mineral:matrix ratio was assessed through Raman spectroscopy.
Results
A decrease in both trabecular thickness and volume ratio, and an increase in trabecular separation were observed at the 1‐day evaluation (immediate withdrawal). After 30 and 60 days, the alveolar bone parameters were found similar to control, except for the mineral:matrix ratio in the long‐term abstinence.
Conclusions
EtOH binge drinking during adolescence results in alveolar bone damage that may persist in adulthood, even after abstinence. |
| doi_str_mv | 10.1111/acer.14501 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2458955649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2458955649</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3571-1ee2a6140daff2eca5d51716495c4e7c8542200dc7c974c7da32d40d66f77a133</originalsourceid><addsrcrecordid>eNp9kc9KxDAQh4Mouq5efAAJeBGhmrRJsz3Wtf6BBUX0XGIy1a7ZZk1adW8-gs_okxjt6sGDuQzMfHxk5ofQDiWHNLwjqcAdUsYJXUEDyhMSkViIVTQgoRmlhIw20Kb3U0IIG6XpOtpIEpryjJEBssd1cw8fb--T-hFw8Tq3vnOATzoX-jjX1oBX0CjAF43uFHh8Aq2rZ9C00uCiqkC1HtcNzs0zWCMdPrYN4PZBtvgKnK99-z3VnWkfrNVbaK2SxsP2sg7R7WlxMz6PJpdnF-N8EqmECxpRgFimlBEtqyoGJbnmVNCUZVwxEGrEWRwTopVQmWBKaJnEOtBpWgkhaZIM0X7vnTv71IFvy1kdFjFGNmA7X8aMjzLOgzCge3_Qqe1cE34XKJElQrCYBeqgp5Sz3juoynk4g3SLkpLyK4byK4byO4YA7y6V3d0M9C_6c_cA0B54qQ0s_lGV-bi47qWfdbmSpA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479377424</pqid></control><display><type>article</type><title>Binge‐Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Maia, Cristiane do Socorro Ferraz ; Queiroz, Letícia Yoshitome ; Oliveira, Igor Gonçalves ; Silva, Carla Cristiane Soares ; Cunha, Rodrigo A. ; Souza‐Monteiro, Deiweson ; Ferreira, Maria Karolina Martins ; Silveira, Felipe Martins ; Silva, Jordana Conceição ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Martins, Marco Antônio Trevizani ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues</creator><creatorcontrib>Maia, Cristiane do Socorro Ferraz ; Queiroz, Letícia Yoshitome ; Oliveira, Igor Gonçalves ; Silva, Carla Cristiane Soares ; Cunha, Rodrigo A. ; Souza‐Monteiro, Deiweson ; Ferreira, Maria Karolina Martins ; Silveira, Felipe Martins ; Silva, Jordana Conceição ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Martins, Marco Antônio Trevizani ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues</creatorcontrib><description>Background
Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed to investigate the effect of EtOH binge drinking on the alveolar bone and the long‐term consequences after abstinence.
Methods
Adolescent female Wistar rats (35 days old) were exposed to 4 cycles of EtOH binge drinking (3 g/kg/d; 3 days On‐4 days Off) or distilled water (control group). Alveolar bone micromorphology and vertical bone distance were evaluated at 1, 30, and 60 days after that last EtOH intake through X‐ray computed microtomography. The mineral:matrix ratio was assessed through Raman spectroscopy.
Results
A decrease in both trabecular thickness and volume ratio, and an increase in trabecular separation were observed at the 1‐day evaluation (immediate withdrawal). After 30 and 60 days, the alveolar bone parameters were found similar to control, except for the mineral:matrix ratio in the long‐term abstinence.
Conclusions
EtOH binge drinking during adolescence results in alveolar bone damage that may persist in adulthood, even after abstinence.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/acer.14501</identifier><identifier>PMID: 33165940</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescence ; Adolescents ; Alcohol ; Alcohol use ; Alveolar bone ; Alveolar Bone Loss - chemically induced ; Alveolar Bone Loss - diagnostic imaging ; Animals ; Binge drinking ; Child development ; Drinking behavior ; Ethanol ; Ethanol - adverse effects ; Female ; Gum disease ; Homeostasis ; Long bone ; Mandibular Diseases - chemically induced ; Mandibular Diseases - diagnostic imaging ; Musculoskeletal system ; Periodontal Disease ; Public health ; Raman spectroscopy ; Rats ; Rats, Wistar ; Solvents - adverse effects ; Teenagers ; Underage Drinking ; X-Ray Microtomography</subject><ispartof>Alcoholism, clinical and experimental research, 2021-01, Vol.45 (1), p.56-63</ispartof><rights>2020 by the Research Society on Alcoholism</rights><rights>2020 by the Research Society on Alcoholism.</rights><rights>2021 Research Society on Alcoholism</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-1ee2a6140daff2eca5d51716495c4e7c8542200dc7c974c7da32d40d66f77a133</citedby><cites>FETCH-LOGICAL-c3571-1ee2a6140daff2eca5d51716495c4e7c8542200dc7c974c7da32d40d66f77a133</cites><orcidid>0000-0001-7834-3319 ; 0000-0003-2550-6422 ; 0000-0001-8662-5965 ; 0000-0001-9076-2460 ; 0000-0003-4493-7375 ; 0000-0003-1843-4184 ; 0000-0003-1486-4013 ; 0000-0002-1382-0150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facer.14501$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facer.14501$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33165940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maia, Cristiane do Socorro Ferraz</creatorcontrib><creatorcontrib>Queiroz, Letícia Yoshitome</creatorcontrib><creatorcontrib>Oliveira, Igor Gonçalves</creatorcontrib><creatorcontrib>Silva, Carla Cristiane Soares</creatorcontrib><creatorcontrib>Cunha, Rodrigo A.</creatorcontrib><creatorcontrib>Souza‐Monteiro, Deiweson</creatorcontrib><creatorcontrib>Ferreira, Maria Karolina Martins</creatorcontrib><creatorcontrib>Silveira, Felipe Martins</creatorcontrib><creatorcontrib>Silva, Jordana Conceição</creatorcontrib><creatorcontrib>Balbinot, Gabriela de Souza</creatorcontrib><creatorcontrib>Collares, Fabrício Mezzomo</creatorcontrib><creatorcontrib>Martins, Marco Antônio Trevizani</creatorcontrib><creatorcontrib>Martins, Manoela Domingues</creatorcontrib><creatorcontrib>Lima, Rafael Rodrigues</creatorcontrib><title>Binge‐Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background
Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed to investigate the effect of EtOH binge drinking on the alveolar bone and the long‐term consequences after abstinence.
Methods
Adolescent female Wistar rats (35 days old) were exposed to 4 cycles of EtOH binge drinking (3 g/kg/d; 3 days On‐4 days Off) or distilled water (control group). Alveolar bone micromorphology and vertical bone distance were evaluated at 1, 30, and 60 days after that last EtOH intake through X‐ray computed microtomography. The mineral:matrix ratio was assessed through Raman spectroscopy.
Results
A decrease in both trabecular thickness and volume ratio, and an increase in trabecular separation were observed at the 1‐day evaluation (immediate withdrawal). After 30 and 60 days, the alveolar bone parameters were found similar to control, except for the mineral:matrix ratio in the long‐term abstinence.
Conclusions
EtOH binge drinking during adolescence results in alveolar bone damage that may persist in adulthood, even after abstinence.</description><subject>Adolescence</subject><subject>Adolescents</subject><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Alveolar bone</subject><subject>Alveolar Bone Loss - chemically induced</subject><subject>Alveolar Bone Loss - diagnostic imaging</subject><subject>Animals</subject><subject>Binge drinking</subject><subject>Child development</subject><subject>Drinking behavior</subject><subject>Ethanol</subject><subject>Ethanol - adverse effects</subject><subject>Female</subject><subject>Gum disease</subject><subject>Homeostasis</subject><subject>Long bone</subject><subject>Mandibular Diseases - chemically induced</subject><subject>Mandibular Diseases - diagnostic imaging</subject><subject>Musculoskeletal system</subject><subject>Periodontal Disease</subject><subject>Public health</subject><subject>Raman spectroscopy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Solvents - adverse effects</subject><subject>Teenagers</subject><subject>Underage Drinking</subject><subject>X-Ray Microtomography</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9KxDAQh4Mouq5efAAJeBGhmrRJsz3Wtf6BBUX0XGIy1a7ZZk1adW8-gs_okxjt6sGDuQzMfHxk5ofQDiWHNLwjqcAdUsYJXUEDyhMSkViIVTQgoRmlhIw20Kb3U0IIG6XpOtpIEpryjJEBssd1cw8fb--T-hFw8Tq3vnOATzoX-jjX1oBX0CjAF43uFHh8Aq2rZ9C00uCiqkC1HtcNzs0zWCMdPrYN4PZBtvgKnK99-z3VnWkfrNVbaK2SxsP2sg7R7WlxMz6PJpdnF-N8EqmECxpRgFimlBEtqyoGJbnmVNCUZVwxEGrEWRwTopVQmWBKaJnEOtBpWgkhaZIM0X7vnTv71IFvy1kdFjFGNmA7X8aMjzLOgzCge3_Qqe1cE34XKJElQrCYBeqgp5Sz3juoynk4g3SLkpLyK4byK4byO4YA7y6V3d0M9C_6c_cA0B54qQ0s_lGV-bi47qWfdbmSpA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Maia, Cristiane do Socorro Ferraz</creator><creator>Queiroz, Letícia Yoshitome</creator><creator>Oliveira, Igor Gonçalves</creator><creator>Silva, Carla Cristiane Soares</creator><creator>Cunha, Rodrigo A.</creator><creator>Souza‐Monteiro, Deiweson</creator><creator>Ferreira, Maria Karolina Martins</creator><creator>Silveira, Felipe Martins</creator><creator>Silva, Jordana Conceição</creator><creator>Balbinot, Gabriela de Souza</creator><creator>Collares, Fabrício Mezzomo</creator><creator>Martins, Marco Antônio Trevizani</creator><creator>Martins, Manoela Domingues</creator><creator>Lima, Rafael Rodrigues</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K7.</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7834-3319</orcidid><orcidid>https://orcid.org/0000-0003-2550-6422</orcidid><orcidid>https://orcid.org/0000-0001-8662-5965</orcidid><orcidid>https://orcid.org/0000-0001-9076-2460</orcidid><orcidid>https://orcid.org/0000-0003-4493-7375</orcidid><orcidid>https://orcid.org/0000-0003-1843-4184</orcidid><orcidid>https://orcid.org/0000-0003-1486-4013</orcidid><orcidid>https://orcid.org/0000-0002-1382-0150</orcidid></search><sort><creationdate>202101</creationdate><title>Binge‐Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood</title><author>Maia, Cristiane do Socorro Ferraz ; Queiroz, Letícia Yoshitome ; Oliveira, Igor Gonçalves ; Silva, Carla Cristiane Soares ; Cunha, Rodrigo A. ; Souza‐Monteiro, Deiweson ; Ferreira, Maria Karolina Martins ; Silveira, Felipe Martins ; Silva, Jordana Conceição ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Martins, Marco Antônio Trevizani ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-1ee2a6140daff2eca5d51716495c4e7c8542200dc7c974c7da32d40d66f77a133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescence</topic><topic>Adolescents</topic><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Alveolar bone</topic><topic>Alveolar Bone Loss - chemically induced</topic><topic>Alveolar Bone Loss - diagnostic imaging</topic><topic>Animals</topic><topic>Binge drinking</topic><topic>Child development</topic><topic>Drinking behavior</topic><topic>Ethanol</topic><topic>Ethanol - adverse effects</topic><topic>Female</topic><topic>Gum disease</topic><topic>Homeostasis</topic><topic>Long bone</topic><topic>Mandibular Diseases - chemically induced</topic><topic>Mandibular Diseases - diagnostic imaging</topic><topic>Musculoskeletal system</topic><topic>Periodontal Disease</topic><topic>Public health</topic><topic>Raman spectroscopy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Solvents - adverse effects</topic><topic>Teenagers</topic><topic>Underage Drinking</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maia, Cristiane do Socorro Ferraz</creatorcontrib><creatorcontrib>Queiroz, Letícia Yoshitome</creatorcontrib><creatorcontrib>Oliveira, Igor Gonçalves</creatorcontrib><creatorcontrib>Silva, Carla Cristiane Soares</creatorcontrib><creatorcontrib>Cunha, Rodrigo A.</creatorcontrib><creatorcontrib>Souza‐Monteiro, Deiweson</creatorcontrib><creatorcontrib>Ferreira, Maria Karolina Martins</creatorcontrib><creatorcontrib>Silveira, Felipe Martins</creatorcontrib><creatorcontrib>Silva, Jordana Conceição</creatorcontrib><creatorcontrib>Balbinot, Gabriela de Souza</creatorcontrib><creatorcontrib>Collares, Fabrício Mezzomo</creatorcontrib><creatorcontrib>Martins, Marco Antônio Trevizani</creatorcontrib><creatorcontrib>Martins, Manoela Domingues</creatorcontrib><creatorcontrib>Lima, Rafael Rodrigues</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maia, Cristiane do Socorro Ferraz</au><au>Queiroz, Letícia Yoshitome</au><au>Oliveira, Igor Gonçalves</au><au>Silva, Carla Cristiane Soares</au><au>Cunha, Rodrigo A.</au><au>Souza‐Monteiro, Deiweson</au><au>Ferreira, Maria Karolina Martins</au><au>Silveira, Felipe Martins</au><au>Silva, Jordana Conceição</au><au>Balbinot, Gabriela de Souza</au><au>Collares, Fabrício Mezzomo</au><au>Martins, Marco Antônio Trevizani</au><au>Martins, Manoela Domingues</au><au>Lima, Rafael Rodrigues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binge‐Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2021-01</date><risdate>2021</risdate><volume>45</volume><issue>1</issue><spage>56</spage><epage>63</epage><pages>56-63</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><abstract>Background
Alcohol (EtOH) intake during adolescence has become an important public health issue. Although the detrimental effects of EtOH intake on the musculoskeletal system are well known, only a few studies have investigated its impact on the stomatognathic system of adolescents. This study aimed to investigate the effect of EtOH binge drinking on the alveolar bone and the long‐term consequences after abstinence.
Methods
Adolescent female Wistar rats (35 days old) were exposed to 4 cycles of EtOH binge drinking (3 g/kg/d; 3 days On‐4 days Off) or distilled water (control group). Alveolar bone micromorphology and vertical bone distance were evaluated at 1, 30, and 60 days after that last EtOH intake through X‐ray computed microtomography. The mineral:matrix ratio was assessed through Raman spectroscopy.
Results
A decrease in both trabecular thickness and volume ratio, and an increase in trabecular separation were observed at the 1‐day evaluation (immediate withdrawal). After 30 and 60 days, the alveolar bone parameters were found similar to control, except for the mineral:matrix ratio in the long‐term abstinence.
Conclusions
EtOH binge drinking during adolescence results in alveolar bone damage that may persist in adulthood, even after abstinence.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33165940</pmid><doi>10.1111/acer.14501</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7834-3319</orcidid><orcidid>https://orcid.org/0000-0003-2550-6422</orcidid><orcidid>https://orcid.org/0000-0001-8662-5965</orcidid><orcidid>https://orcid.org/0000-0001-9076-2460</orcidid><orcidid>https://orcid.org/0000-0003-4493-7375</orcidid><orcidid>https://orcid.org/0000-0003-1843-4184</orcidid><orcidid>https://orcid.org/0000-0003-1486-4013</orcidid><orcidid>https://orcid.org/0000-0002-1382-0150</orcidid></addata></record> |
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| ispartof | Alcoholism, clinical and experimental research, 2021-01, Vol.45 (1), p.56-63 |
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| subjects | Adolescence Adolescents Alcohol Alcohol use Alveolar bone Alveolar Bone Loss - chemically induced Alveolar Bone Loss - diagnostic imaging Animals Binge drinking Child development Drinking behavior Ethanol Ethanol - adverse effects Female Gum disease Homeostasis Long bone Mandibular Diseases - chemically induced Mandibular Diseases - diagnostic imaging Musculoskeletal system Periodontal Disease Public health Raman spectroscopy Rats Rats, Wistar Solvents - adverse effects Teenagers Underage Drinking X-Ray Microtomography |
| title | Binge‐Like Exposure During Adolescence Induces Detrimental Effects in Alveolar Bone that Persist in Adulthood |
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