An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity. To fill the scarcity of clinically relevant models of GEP-NEN, we here established 25 lines of NEN organ...

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Veröffentlicht in:	Cell 2020-11, Vol.183 (5), p.1420-1435.e21
Hauptverfasser:	Kawasaki, Kenta, Toshimitsu, Kohta, Matano, Mami, Fujita, Masashi, Fujii, Masayuki, Togasaki, Kazuhiro, Ebisudani, Toshiki, Shimokawa, Mariko, Takano, Ai, Takahashi, Sirirat, Ohta, Yuki, Nanki, Kosaku, Igarashi, Ryo, Ishimaru, Kazuhiro, Ishida, Hiroki, Sukawa, Yasutaka, Sugimoto, Shinya, Saito, Yoshimasa, Maejima, Kazuhiro, Sasagawa, Shota, Lee, Hwajin, Kim, Hong-Gee, Ha, Kyungsik, Hamamoto, Junko, Fukunaga, Koichi, Maekawa, Aya, Tanabe, Minoru, Ishihara, Soichiro, Hamamoto, Yasuo, Yasuda, Hiroyuki, Sekine, Shigeki, Kudo, Atsushi, Kitagawa, Yuko, Kanai, Takanori, Nakagawa, Hidewaki, Sato, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	3D culture Animals Biological Specimen Banks Chromosomes, Human - genetics CRISPR-Cas9 epigenome fusion gene gastrinoma Genotype Humans Intercellular Signaling Peptides and Proteins - metabolism Intestinal Neoplasms - genetics Intestinal Neoplasms - pathology lineage reprogramming Male Mice Models, Genetic multi-omics Mutation - genetics Neuroendocrine Tumors - genetics Neuroendocrine Tumors - pathology NKX2-5 Organoids - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Phenotype stem cell niche Stomach Neoplasms - genetics Stomach Neoplasms - pathology transcription factors Transcriptome - genetics Whole Genome Sequencing
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