Gingival fibroblasts dynamically reprogram cellular metabolism during infection of Porphyromonas gingivalis

•Gingival fibroblasts reprogram metabolism to address P.gingivalis infection.•ABC transporters, GSH and pyrimidine metabolism were altered during infection.•Metabolites in gingival fibroblasts may support the inflammatory responses. The purpose of the present study was to explore the sequential chan...

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Veröffentlicht in:	Archives of oral biology 2021-01, Vol.121, p.104963-104963, Article 104963
Hauptverfasser:	Su, Wenqi, Shi, Jiahong, Zhao, Yunhe, Li, Houxuan, Lei, Lang
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteroidaceae Infections - metabolism Cells, Cultured Dentistry Fibroblasts - metabolism Fibroblasts - microbiology Gingiva - cytology gingival fibroblasts Humans Inflammation Metabolome metabolomics periodontitis Porphyromonas gingivalis Porphyromonas gingivalis - pathogenicity Real-Time Polymerase Chain Reaction
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