Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake. Bioinformatics analysis shows that the three molecules of ubiquitin-specific protease 7 (USP7), p53 and TfR1 form a unique pathway of USP7/p53/...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Free radical biology & medicine 2021-01, Vol.162, p.339-352
Hauptverfasser:	Tang, Li-Jing, Zhou, Yuan-Jing, Xiong, Xiao-Ming, Li, Nian-Sheng, Zhang, Jie-Jie, Luo, Xiu-Ju, Peng, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ferroptosis Heart Ischemia Ischemia/reperfusion p53 Rats Rats, Sprague-Dawley Receptors, Transferrin Reperfusion Transferrin receptor 1 Tumor Suppressor Protein p53 - genetics Ubiquitin-Specific Peptidase 7 - genetics Ubiquitin-specific protease 7
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!