Asymptomatic Infection of Marburg Virus Reservoir Bats Is Explained by a Strategy of Immunoprotective Disease Tolerance

Marburg virus (MARV) is among the most virulent pathogens of primates, including humans. Contributors to severe MARV disease include immune response suppression and inflammatory gene dysregulation (“cytokine storm”), leading to systemic damage and often death. Conversely, MARV causes little to no cl...

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Veröffentlicht in:	Current biology 2021-01, Vol.31 (2), p.257-270.e5
Hauptverfasser:	Guito, Jonathan C., Prescott, Joseph B., Arnold, Catherine E., Amman, Brian R., Schuh, Amy J., Spengler, Jessica R., Sealy, Tara K., Harmon, Jessica R., Coleman-McCray, JoAnn D., Kulcsar, Kirsten A., Nagle, Elyse R., Kumar, Raina, Palacios, Gustavo F., Sanchez-Lockhart, Mariano, Towner, Jonathan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	bat disease tolerance emerging zoonotic pathogen filovirus gene expression immune response Marburg virus monocyte reservoir host virus-host interaction
Online-Zugang:	Volltext
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