Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression
The foods of plants provide the rich nutrition and have protective function in human diseases, including cancers. Genistein is a major isoflavone constituent in soybeans, which has an anti‐cancer role in non‐small‐cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti‐cancer funct...
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| description | The foods of plants provide the rich nutrition and have protective function in human diseases, including cancers. Genistein is a major isoflavone constituent in soybeans, which has an anti‐cancer role in non‐small‐cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti‐cancer function of genistein in NSCLC remains largely unknown. NSCLC cells (H292 and A549) were exposed to genistein. Circular RNA hsa_circ_0031250 (circ_0031250), microRNA (miR)‐873‐5p and forkhead box M1 (FOXM1) abundances were examined via quantitative reverse transcription polymerase chain reaction and Western blotting. The function of genistein, circ_0031250, miR‐873‐5p, and FOXM1 on NSCLC progression was investigated via Cell Counting Kit‐8, colony formation, transwell well, wound healing, flow cytometry, Western blotting and xenograft model. The target relationship was analyzed by dual‐luciferase reporter analysis and RNA immunoprecipitation. Results showed that genistein inhibited NSCLC cell viability in dose‐time‐dependent patterns. circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure. circ_0031250 knockdown aggravated genistein‐caused suppression of cell proliferation, migration and invasion and elevation of apoptosis. miR‐873‐5p expression was decreased in NSCLC samples and cells. miR‐873‐5p was targeted via circ_0031250, and miR‐873‐5p knockdown attenuated the influence of circ_0031250 silence on NSCLC progression in the presence of genistein. FOXM1 was regulated via circ_0031250/miR‐873‐5p axis. miR‐873‐5p constrained cell proliferation, migration and invasion and increased apoptosis via regulating FOXM1 in genistein‐treated cells. circ_0031250 knockdown enhanced the inhibitive function of genistein on NSCLC cell growth in xenograft model. Collectively, genistein repressed NSCLC progression by modulating circ_0031250/miR‐873‐5p/FOXM1 axis. |
| doi_str_mv | 10.1002/iub.2404 |
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Genistein is a major isoflavone constituent in soybeans, which has an anti‐cancer role in non‐small‐cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti‐cancer function of genistein in NSCLC remains largely unknown. NSCLC cells (H292 and A549) were exposed to genistein. Circular RNA hsa_circ_0031250 (circ_0031250), microRNA (miR)‐873‐5p and forkhead box M1 (FOXM1) abundances were examined via quantitative reverse transcription polymerase chain reaction and Western blotting. The function of genistein, circ_0031250, miR‐873‐5p, and FOXM1 on NSCLC progression was investigated via Cell Counting Kit‐8, colony formation, transwell well, wound healing, flow cytometry, Western blotting and xenograft model. The target relationship was analyzed by dual‐luciferase reporter analysis and RNA immunoprecipitation. Results showed that genistein inhibited NSCLC cell viability in dose‐time‐dependent patterns. circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure. circ_0031250 knockdown aggravated genistein‐caused suppression of cell proliferation, migration and invasion and elevation of apoptosis. miR‐873‐5p expression was decreased in NSCLC samples and cells. miR‐873‐5p was targeted via circ_0031250, and miR‐873‐5p knockdown attenuated the influence of circ_0031250 silence on NSCLC progression in the presence of genistein. FOXM1 was regulated via circ_0031250/miR‐873‐5p axis. miR‐873‐5p constrained cell proliferation, migration and invasion and increased apoptosis via regulating FOXM1 in genistein‐treated cells. circ_0031250 knockdown enhanced the inhibitive function of genistein on NSCLC cell growth in xenograft model. Collectively, genistein repressed NSCLC progression by modulating circ_0031250/miR‐873‐5p/FOXM1 axis.</description><identifier>ISSN: 1521-6543</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1002/iub.2404</identifier><identifier>PMID: 33159503</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Anticarcinogenic Agents - pharmacology ; Apoptosis ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell growth ; Cell migration ; Cell Proliferation ; Cell viability ; Circular RNA ; Female ; Flow cytometry ; Food plants ; Forkhead Box Protein M1 - genetics ; Forkhead Box Protein M1 - metabolism ; Forkhead protein ; FOXM1 ; Gene Expression Regulation, Neoplastic - drug effects ; Genistein ; Genistein - pharmacology ; hsa_circ_0031250 ; Humans ; Immunoprecipitation ; Isoflavones ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs - genetics ; Middle Aged ; miRNA ; miR‐873‐5p ; Non-small cell lung carcinoma ; non‐small‐cell lung cancer ; Polymerase chain reaction ; Prognosis ; Reverse transcription ; RNA, Circular - genetics ; Soybeans ; Survival Rate ; Tumor Cells, Cultured ; Western blotting ; Wound healing ; Xenograft Model Antitumor Assays ; Xenografts</subject><ispartof>IUBMB life, 2021-01, Vol.73 (1), p.92-107</ispartof><rights>2020 International Union of Biochemistry and Molecular Biology</rights><rights>2020 International Union of Biochemistry and Molecular Biology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4494-ed6e7515b81374e3bcfed81642b512a26ac2550b2087302df3bdbabe1cafa9fa3</citedby><cites>FETCH-LOGICAL-c4494-ed6e7515b81374e3bcfed81642b512a26ac2550b2087302df3bdbabe1cafa9fa3</cites><orcidid>0000-0002-9515-0233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fiub.2404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fiub.2404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33159503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Yaying</creatorcontrib><creatorcontrib>Xing, Yanwei</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Zhang, Qianqian</creatorcontrib><creatorcontrib>Huang, Shuangjian</creatorcontrib><creatorcontrib>Li, Xinxin</creatorcontrib><creatorcontrib>Gao, Chao</creatorcontrib><title>Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression</title><title>IUBMB life</title><addtitle>IUBMB Life</addtitle><description>The foods of plants provide the rich nutrition and have protective function in human diseases, including cancers. Genistein is a major isoflavone constituent in soybeans, which has an anti‐cancer role in non‐small‐cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti‐cancer function of genistein in NSCLC remains largely unknown. NSCLC cells (H292 and A549) were exposed to genistein. Circular RNA hsa_circ_0031250 (circ_0031250), microRNA (miR)‐873‐5p and forkhead box M1 (FOXM1) abundances were examined via quantitative reverse transcription polymerase chain reaction and Western blotting. The function of genistein, circ_0031250, miR‐873‐5p, and FOXM1 on NSCLC progression was investigated via Cell Counting Kit‐8, colony formation, transwell well, wound healing, flow cytometry, Western blotting and xenograft model. The target relationship was analyzed by dual‐luciferase reporter analysis and RNA immunoprecipitation. Results showed that genistein inhibited NSCLC cell viability in dose‐time‐dependent patterns. circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure. circ_0031250 knockdown aggravated genistein‐caused suppression of cell proliferation, migration and invasion and elevation of apoptosis. miR‐873‐5p expression was decreased in NSCLC samples and cells. miR‐873‐5p was targeted via circ_0031250, and miR‐873‐5p knockdown attenuated the influence of circ_0031250 silence on NSCLC progression in the presence of genistein. FOXM1 was regulated via circ_0031250/miR‐873‐5p axis. miR‐873‐5p constrained cell proliferation, migration and invasion and increased apoptosis via regulating FOXM1 in genistein‐treated cells. circ_0031250 knockdown enhanced the inhibitive function of genistein on NSCLC cell growth in xenograft model. Collectively, genistein repressed NSCLC progression by modulating circ_0031250/miR‐873‐5p/FOXM1 axis.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Cell Proliferation</subject><subject>Cell viability</subject><subject>Circular RNA</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Food plants</subject><subject>Forkhead Box Protein M1 - genetics</subject><subject>Forkhead Box Protein M1 - metabolism</subject><subject>Forkhead protein</subject><subject>FOXM1</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Genistein</subject><subject>Genistein - pharmacology</subject><subject>hsa_circ_0031250</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>Isoflavones</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>miR‐873‐5p</subject><subject>Non-small cell lung carcinoma</subject><subject>non‐small‐cell lung cancer</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Reverse transcription</subject><subject>RNA, Circular - genetics</subject><subject>Soybeans</subject><subject>Survival Rate</subject><subject>Tumor Cells, Cultured</subject><subject>Western blotting</subject><subject>Wound healing</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenografts</subject><issn>1521-6543</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdtqFTEUhkOx2INCn0AC3ngz3Tnu2XOpxdZCpWBb8C4kmTW7KTPJmLWnuu8KfQGf0Scx2x4EwVxkBfLxrR9-Qg44O-SMiVmY3KFQTG2RXa4Fr-Za8xfPbyV3yB7iDSunZs1LsiMl141mcpfcX6Q1DZi63t6mCHQJMeAKQqQhXgcXVkiv0RofsjeMSS40mw3hy6-7n4talluPs-Pzr585tT8C0lWiOI1jBkQaUyz_ONi-L9ND39N-ikvqbfSQ6ZjTcsOFFF-R7c72CK8f5z65Ov54efSpOjs_OT16f1Z5pRpVQTuHWnPtFlzWCqTzHbQLPlfCaS6smFsvtGZOsBKNibaTrnXWAfe2s01n5T559-Atu79NgCszBNwEsxHShEYovaiFYI0s6Nt_0Js05VjSFaoWjeKS8b9CnxNihs6MOQw2rw1nZlOMKcWYTTEFffMonNwA7TP41EQBqgfge-hh_V-ROb368Ef4GzIdmno</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Yu, Yaying</creator><creator>Xing, Yanwei</creator><creator>Zhang, Qian</creator><creator>Zhang, Qianqian</creator><creator>Huang, Shuangjian</creator><creator>Li, Xinxin</creator><creator>Gao, Chao</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9515-0233</orcidid></search><sort><creationdate>202101</creationdate><title>Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression</title><author>Yu, Yaying ; Xing, Yanwei ; Zhang, Qian ; Zhang, Qianqian ; Huang, Shuangjian ; Li, Xinxin ; Gao, Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4494-ed6e7515b81374e3bcfed81642b512a26ac2550b2087302df3bdbabe1cafa9fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell growth</topic><topic>Cell migration</topic><topic>Cell Proliferation</topic><topic>Cell viability</topic><topic>Circular RNA</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Food plants</topic><topic>Forkhead Box Protein M1 - genetics</topic><topic>Forkhead Box Protein M1 - metabolism</topic><topic>Forkhead protein</topic><topic>FOXM1</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Genistein</topic><topic>Genistein - pharmacology</topic><topic>hsa_circ_0031250</topic><topic>Humans</topic><topic>Immunoprecipitation</topic><topic>Isoflavones</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>miR‐873‐5p</topic><topic>Non-small cell lung carcinoma</topic><topic>non‐small‐cell lung cancer</topic><topic>Polymerase chain reaction</topic><topic>Prognosis</topic><topic>Reverse transcription</topic><topic>RNA, Circular - genetics</topic><topic>Soybeans</topic><topic>Survival Rate</topic><topic>Tumor Cells, Cultured</topic><topic>Western blotting</topic><topic>Wound healing</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Xenografts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Yaying</creatorcontrib><creatorcontrib>Xing, Yanwei</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Zhang, Qianqian</creatorcontrib><creatorcontrib>Huang, Shuangjian</creatorcontrib><creatorcontrib>Li, Xinxin</creatorcontrib><creatorcontrib>Gao, Chao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>IUBMB life</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Yaying</au><au>Xing, Yanwei</au><au>Zhang, Qian</au><au>Zhang, Qianqian</au><au>Huang, Shuangjian</au><au>Li, Xinxin</au><au>Gao, Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression</atitle><jtitle>IUBMB life</jtitle><addtitle>IUBMB Life</addtitle><date>2021-01</date><risdate>2021</risdate><volume>73</volume><issue>1</issue><spage>92</spage><epage>107</epage><pages>92-107</pages><issn>1521-6543</issn><eissn>1521-6551</eissn><abstract>The foods of plants provide the rich nutrition and have protective function in human diseases, including cancers. Genistein is a major isoflavone constituent in soybeans, which has an anti‐cancer role in non‐small‐cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti‐cancer function of genistein in NSCLC remains largely unknown. NSCLC cells (H292 and A549) were exposed to genistein. Circular RNA hsa_circ_0031250 (circ_0031250), microRNA (miR)‐873‐5p and forkhead box M1 (FOXM1) abundances were examined via quantitative reverse transcription polymerase chain reaction and Western blotting. The function of genistein, circ_0031250, miR‐873‐5p, and FOXM1 on NSCLC progression was investigated via Cell Counting Kit‐8, colony formation, transwell well, wound healing, flow cytometry, Western blotting and xenograft model. The target relationship was analyzed by dual‐luciferase reporter analysis and RNA immunoprecipitation. Results showed that genistein inhibited NSCLC cell viability in dose‐time‐dependent patterns. circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure. circ_0031250 knockdown aggravated genistein‐caused suppression of cell proliferation, migration and invasion and elevation of apoptosis. miR‐873‐5p expression was decreased in NSCLC samples and cells. miR‐873‐5p was targeted via circ_0031250, and miR‐873‐5p knockdown attenuated the influence of circ_0031250 silence on NSCLC progression in the presence of genistein. FOXM1 was regulated via circ_0031250/miR‐873‐5p axis. miR‐873‐5p constrained cell proliferation, migration and invasion and increased apoptosis via regulating FOXM1 in genistein‐treated cells. circ_0031250 knockdown enhanced the inhibitive function of genistein on NSCLC cell growth in xenograft model. Collectively, genistein repressed NSCLC progression by modulating circ_0031250/miR‐873‐5p/FOXM1 axis.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33159503</pmid><doi>10.1002/iub.2404</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-9515-0233</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anticarcinogenic Agents - pharmacology Apoptosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell growth Cell migration Cell Proliferation Cell viability Circular RNA Female Flow cytometry Food plants Forkhead Box Protein M1 - genetics Forkhead Box Protein M1 - metabolism Forkhead protein FOXM1 Gene Expression Regulation, Neoplastic - drug effects Genistein Genistein - pharmacology hsa_circ_0031250 Humans Immunoprecipitation Isoflavones Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics Middle Aged miRNA miR‐873‐5p Non-small cell lung carcinoma non‐small‐cell lung cancer Polymerase chain reaction Prognosis Reverse transcription RNA, Circular - genetics Soybeans Survival Rate Tumor Cells, Cultured Western blotting Wound healing Xenograft Model Antitumor Assays Xenografts |
| title | Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression |
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