Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats
Objective The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)‐induced obesity in Wistar rats. Methods Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The diet was admini...
Gespeichert in:
Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2021-01, Vol.29 (1), p.116-124 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 124 |
---|---|
container_issue | 1 |
container_start_page | 116 |
container_title | Obesity (Silver Spring, Md.) |
container_volume | 29 |
creator | Oliveira, Simone Feijó, Grace dos Santos Neto, João Jantsch, Jeferson Braga, Matheus Filipe Castro, Luís Felipe dos Santos Giovenardi, Márcia Porawski, Marilene Guedes, Renata Padilha |
description | Objective
The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)‐induced obesity in Wistar rats.
Methods
Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The diet was administered for 20 weeks; Zn treatment (10 mg/kg/d) started at week 16 and it was conducted until the end of the diet protocol. Weight gain, visceral fat, and plasma levels of glucose, triglycerides, insulin, TNF‐α, and IL‐6, as well as homeostatic model assessment of insulin resistance, were assessed. Glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba‐1) expression in the cerebral cortex and toll‐like receptor 4 (TLR‐4) in the cerebral cortex and hippocampus were evaluated. Memory was assessed by the novel object recognition test.
Results
CAF diet increased weight gain, visceral fat, and plasma glucose, triglyceride, and TNF‐α levels. Zn reversed the hyperglycemia caused by CAF diet and reduced IL‐6 levels. In the cerebral cortex, GFAP was similar between groups; Iba‐1 was increased by CAF diet but reduced in the CAF+Zn group. Zn reduced CAF‐dependent TLR‐4 increase in the hippocampus but not in the cerebral cortex. CAF‐fed animals showed impaired recognition memory, whereas Zn reversed it.
Conclusions
These findings demonstrate that Zn partially reverted obesity‐related metabolic dysfunction and reduced neuroinflammation and memory deficit caused by CAF diet. |
doi_str_mv | 10.1002/oby.23024 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2458039429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2458039429</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3534-def50a185c76314840d811fde4c3b926d53dae01bd8df482dacc36caa5b47cb63</originalsourceid><addsrcrecordid>eNp10ctKxDAUBuAgiveFLyAFN7qYmaRJell6V1AHvIC6KWlyCpE2GZNW6c5H8Bl9EqPVWQiuEsiXn8P5EdoieEwwjie27McxxTFbQKskp3iU0vx-cX7PyApa8_4JY5ZgTpbRCqWEc5qnq6h71EZGN91sVkMDphWttiY6AulAePDRtASv2_7j7f0aatGCiq6gc1abqhZNM2hhVHTezJx9CR8uoRWlrbWMTjoj5--X0FjXR9pE16L1G2ipErWHzZ9zHd2dHN8eno0upqfnh_sXI0k5ZSMFFceCZFymCSUsY1hlhFQKmKRlHieKUyUAk1JlqmJZrISUNJFC8JKlskzoOtodcsNwzx34tmi0l1DXwoDtfBEznmGaszgPdOcPfbKdM2G6oFJOaJYnPKi9QUlnvXdQFTOnG-H6guDiq4sidFF8dxHs9k9iVzag5vJ3-QFMBvCqa-j_TyqmBw9D5CfBr5XX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2475138965</pqid></control><display><type>article</type><title>Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats</title><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Oliveira, Simone ; Feijó, Grace dos Santos ; Neto, João ; Jantsch, Jeferson ; Braga, Matheus Filipe ; Castro, Luís Felipe dos Santos ; Giovenardi, Márcia ; Porawski, Marilene ; Guedes, Renata Padilha</creator><creatorcontrib>Oliveira, Simone ; Feijó, Grace dos Santos ; Neto, João ; Jantsch, Jeferson ; Braga, Matheus Filipe ; Castro, Luís Felipe dos Santos ; Giovenardi, Márcia ; Porawski, Marilene ; Guedes, Renata Padilha</creatorcontrib><description>Objective
The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)‐induced obesity in Wistar rats.
Methods
Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The diet was administered for 20 weeks; Zn treatment (10 mg/kg/d) started at week 16 and it was conducted until the end of the diet protocol. Weight gain, visceral fat, and plasma levels of glucose, triglycerides, insulin, TNF‐α, and IL‐6, as well as homeostatic model assessment of insulin resistance, were assessed. Glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba‐1) expression in the cerebral cortex and toll‐like receptor 4 (TLR‐4) in the cerebral cortex and hippocampus were evaluated. Memory was assessed by the novel object recognition test.
Results
CAF diet increased weight gain, visceral fat, and plasma glucose, triglyceride, and TNF‐α levels. Zn reversed the hyperglycemia caused by CAF diet and reduced IL‐6 levels. In the cerebral cortex, GFAP was similar between groups; Iba‐1 was increased by CAF diet but reduced in the CAF+Zn group. Zn reduced CAF‐dependent TLR‐4 increase in the hippocampus but not in the cerebral cortex. CAF‐fed animals showed impaired recognition memory, whereas Zn reversed it.
Conclusions
These findings demonstrate that Zn partially reverted obesity‐related metabolic dysfunction and reduced neuroinflammation and memory deficit caused by CAF diet.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.23024</identifier><identifier>PMID: 33155397</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animal cognition ; Carbohydrates ; Cytokines ; Diet ; Glucose ; Inflammation ; Insulin resistance ; Kinases ; Memory ; Metabolism ; Obesity ; Plasma ; Proteins ; Rodents ; Triglycerides ; Tumor necrosis factor-TNF</subject><ispartof>Obesity (Silver Spring, Md.), 2021-01, Vol.29 (1), p.116-124</ispartof><rights>2020 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-def50a185c76314840d811fde4c3b926d53dae01bd8df482dacc36caa5b47cb63</citedby><cites>FETCH-LOGICAL-c3534-def50a185c76314840d811fde4c3b926d53dae01bd8df482dacc36caa5b47cb63</cites><orcidid>0000-0002-0336-5238 ; 0000-0002-1855-1308 ; 0000-0003-3412-8507 ; 0000-0003-0903-8956 ; 0000-0001-8361-999X ; 0000-0001-8765-2113 ; 0000-0003-3680-5815 ; 0000-0003-3213-2641 ; 0000-0002-4456-767X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.23024$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.23024$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33155397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Simone</creatorcontrib><creatorcontrib>Feijó, Grace dos Santos</creatorcontrib><creatorcontrib>Neto, João</creatorcontrib><creatorcontrib>Jantsch, Jeferson</creatorcontrib><creatorcontrib>Braga, Matheus Filipe</creatorcontrib><creatorcontrib>Castro, Luís Felipe dos Santos</creatorcontrib><creatorcontrib>Giovenardi, Márcia</creatorcontrib><creatorcontrib>Porawski, Marilene</creatorcontrib><creatorcontrib>Guedes, Renata Padilha</creatorcontrib><title>Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)‐induced obesity in Wistar rats.
Methods
Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The diet was administered for 20 weeks; Zn treatment (10 mg/kg/d) started at week 16 and it was conducted until the end of the diet protocol. Weight gain, visceral fat, and plasma levels of glucose, triglycerides, insulin, TNF‐α, and IL‐6, as well as homeostatic model assessment of insulin resistance, were assessed. Glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba‐1) expression in the cerebral cortex and toll‐like receptor 4 (TLR‐4) in the cerebral cortex and hippocampus were evaluated. Memory was assessed by the novel object recognition test.
Results
CAF diet increased weight gain, visceral fat, and plasma glucose, triglyceride, and TNF‐α levels. Zn reversed the hyperglycemia caused by CAF diet and reduced IL‐6 levels. In the cerebral cortex, GFAP was similar between groups; Iba‐1 was increased by CAF diet but reduced in the CAF+Zn group. Zn reduced CAF‐dependent TLR‐4 increase in the hippocampus but not in the cerebral cortex. CAF‐fed animals showed impaired recognition memory, whereas Zn reversed it.
Conclusions
These findings demonstrate that Zn partially reverted obesity‐related metabolic dysfunction and reduced neuroinflammation and memory deficit caused by CAF diet.</description><subject>Animal cognition</subject><subject>Carbohydrates</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Glucose</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Memory</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Triglycerides</subject><subject>Tumor necrosis factor-TNF</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10ctKxDAUBuAgiveFLyAFN7qYmaRJell6V1AHvIC6KWlyCpE2GZNW6c5H8Bl9EqPVWQiuEsiXn8P5EdoieEwwjie27McxxTFbQKskp3iU0vx-cX7PyApa8_4JY5ZgTpbRCqWEc5qnq6h71EZGN91sVkMDphWttiY6AulAePDRtASv2_7j7f0aatGCiq6gc1abqhZNM2hhVHTezJx9CR8uoRWlrbWMTjoj5--X0FjXR9pE16L1G2ipErWHzZ9zHd2dHN8eno0upqfnh_sXI0k5ZSMFFceCZFymCSUsY1hlhFQKmKRlHieKUyUAk1JlqmJZrISUNJFC8JKlskzoOtodcsNwzx34tmi0l1DXwoDtfBEznmGaszgPdOcPfbKdM2G6oFJOaJYnPKi9QUlnvXdQFTOnG-H6guDiq4sidFF8dxHs9k9iVzag5vJ3-QFMBvCqa-j_TyqmBw9D5CfBr5XX</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Oliveira, Simone</creator><creator>Feijó, Grace dos Santos</creator><creator>Neto, João</creator><creator>Jantsch, Jeferson</creator><creator>Braga, Matheus Filipe</creator><creator>Castro, Luís Felipe dos Santos</creator><creator>Giovenardi, Márcia</creator><creator>Porawski, Marilene</creator><creator>Guedes, Renata Padilha</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0336-5238</orcidid><orcidid>https://orcid.org/0000-0002-1855-1308</orcidid><orcidid>https://orcid.org/0000-0003-3412-8507</orcidid><orcidid>https://orcid.org/0000-0003-0903-8956</orcidid><orcidid>https://orcid.org/0000-0001-8361-999X</orcidid><orcidid>https://orcid.org/0000-0001-8765-2113</orcidid><orcidid>https://orcid.org/0000-0003-3680-5815</orcidid><orcidid>https://orcid.org/0000-0003-3213-2641</orcidid><orcidid>https://orcid.org/0000-0002-4456-767X</orcidid></search><sort><creationdate>202101</creationdate><title>Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats</title><author>Oliveira, Simone ; Feijó, Grace dos Santos ; Neto, João ; Jantsch, Jeferson ; Braga, Matheus Filipe ; Castro, Luís Felipe dos Santos ; Giovenardi, Márcia ; Porawski, Marilene ; Guedes, Renata Padilha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-def50a185c76314840d811fde4c3b926d53dae01bd8df482dacc36caa5b47cb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal cognition</topic><topic>Carbohydrates</topic><topic>Cytokines</topic><topic>Diet</topic><topic>Glucose</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Memory</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Triglycerides</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Simone</creatorcontrib><creatorcontrib>Feijó, Grace dos Santos</creatorcontrib><creatorcontrib>Neto, João</creatorcontrib><creatorcontrib>Jantsch, Jeferson</creatorcontrib><creatorcontrib>Braga, Matheus Filipe</creatorcontrib><creatorcontrib>Castro, Luís Felipe dos Santos</creatorcontrib><creatorcontrib>Giovenardi, Márcia</creatorcontrib><creatorcontrib>Porawski, Marilene</creatorcontrib><creatorcontrib>Guedes, Renata Padilha</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Simone</au><au>Feijó, Grace dos Santos</au><au>Neto, João</au><au>Jantsch, Jeferson</au><au>Braga, Matheus Filipe</au><au>Castro, Luís Felipe dos Santos</au><au>Giovenardi, Márcia</au><au>Porawski, Marilene</au><au>Guedes, Renata Padilha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2021-01</date><risdate>2021</risdate><volume>29</volume><issue>1</issue><spage>116</spage><epage>124</epage><pages>116-124</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)‐induced obesity in Wistar rats.
Methods
Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The diet was administered for 20 weeks; Zn treatment (10 mg/kg/d) started at week 16 and it was conducted until the end of the diet protocol. Weight gain, visceral fat, and plasma levels of glucose, triglycerides, insulin, TNF‐α, and IL‐6, as well as homeostatic model assessment of insulin resistance, were assessed. Glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba‐1) expression in the cerebral cortex and toll‐like receptor 4 (TLR‐4) in the cerebral cortex and hippocampus were evaluated. Memory was assessed by the novel object recognition test.
Results
CAF diet increased weight gain, visceral fat, and plasma glucose, triglyceride, and TNF‐α levels. Zn reversed the hyperglycemia caused by CAF diet and reduced IL‐6 levels. In the cerebral cortex, GFAP was similar between groups; Iba‐1 was increased by CAF diet but reduced in the CAF+Zn group. Zn reduced CAF‐dependent TLR‐4 increase in the hippocampus but not in the cerebral cortex. CAF‐fed animals showed impaired recognition memory, whereas Zn reversed it.
Conclusions
These findings demonstrate that Zn partially reverted obesity‐related metabolic dysfunction and reduced neuroinflammation and memory deficit caused by CAF diet.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>33155397</pmid><doi>10.1002/oby.23024</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0336-5238</orcidid><orcidid>https://orcid.org/0000-0002-1855-1308</orcidid><orcidid>https://orcid.org/0000-0003-3412-8507</orcidid><orcidid>https://orcid.org/0000-0003-0903-8956</orcidid><orcidid>https://orcid.org/0000-0001-8361-999X</orcidid><orcidid>https://orcid.org/0000-0001-8765-2113</orcidid><orcidid>https://orcid.org/0000-0003-3680-5815</orcidid><orcidid>https://orcid.org/0000-0003-3213-2641</orcidid><orcidid>https://orcid.org/0000-0002-4456-767X</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1930-7381 |
ispartof | Obesity (Silver Spring, Md.), 2021-01, Vol.29 (1), p.116-124 |
issn | 1930-7381 1930-739X |
language | eng |
recordid | cdi_proquest_miscellaneous_2458039429 |
source | Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
subjects | Animal cognition Carbohydrates Cytokines Diet Glucose Inflammation Insulin resistance Kinases Memory Metabolism Obesity Plasma Proteins Rodents Triglycerides Tumor necrosis factor-TNF |
title | Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T15%3A29%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zinc%20Supplementation%20Decreases%20Obesity%E2%80%90Related%20Neuroinflammation%20and%20Improves%20Metabolic%20Function%20and%20Memory%20in%20Rats&rft.jtitle=Obesity%20(Silver%20Spring,%20Md.)&rft.au=Oliveira,%20Simone&rft.date=2021-01&rft.volume=29&rft.issue=1&rft.spage=116&rft.epage=124&rft.pages=116-124&rft.issn=1930-7381&rft.eissn=1930-739X&rft_id=info:doi/10.1002/oby.23024&rft_dat=%3Cproquest_cross%3E2458039429%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2475138965&rft_id=info:pmid/33155397&rfr_iscdi=true |