Failure properties of abdominal aortic aneurysm tissue are orientation dependent
Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study inves...
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| Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2021-02, Vol.114, p.104181-104181, Article 104181 |
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| container_title | Journal of the mechanical behavior of biomedical materials |
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| creator | Polzer, Stanislav Man, Vojtěch Vlachovský, Robert Kubíček, Luboš Kracík, Jan Staffa, Robert Novotný, Tomáš Burša, Jiří Raghavan, M.L. |
| description | Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study investigates the effect of sample orientation on failure properties.
Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength Pult and ultimate tension Tult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests.
Medians of Pult (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p |
| doi_str_mv | 10.1016/j.jmbbm.2020.104181 |
| format | Article |
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Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength Pult and ultimate tension Tult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests.
Medians of Pult (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p < 10−4) and Tult (17.4 N/cm in circumferential vs. 11.2 N/cm in axial direction, p < 10−4) were significantly higher in circumferential direction. For paired data, the median of difference was 411 kPa (p < 10−3) in Pult and 7.4 N/cm (p < 10−4) in Tult in favor of circumferential direction.
In this first study of anisotropy in AAA wall failure properties using paired comparisons, the strength in circumferential orientation was found to be higher than in axial orientation.
[Display omitted]
•Failure properties of Abdominal aortic aneurysm studied.•45 patients; 90 samples in both axial and circumferential direction tested.•Data from 20 patients obtained in both directions for the first time.•Failure properties are significantly higher in circumferential direction.</description><identifier>ISSN: 1751-6161</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2020.104181</identifier><identifier>PMID: 33153925</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Abdominal aortic aneurysm ; Anisotropy ; Aortic Aneurysm, Abdominal ; Aortic Rupture ; Biomechanical Phenomena ; Failure properties ; Female ; Humans ; Mechanical testing ; Risk Assessment ; Sample orientation ; Stress, Mechanical</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2021-02, Vol.114, p.104181-104181, Article 104181</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-36c02409b5932962fc27568da88f026f058f55f29d12318f132696a9f8c966723</citedby><cites>FETCH-LOGICAL-c359t-36c02409b5932962fc27568da88f026f058f55f29d12318f132696a9f8c966723</cites><orcidid>0000-0002-5439-2009 ; 0000-0002-2960-185X ; 0000-0002-7092-9128</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1751616120307232$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33153925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Polzer, Stanislav</creatorcontrib><creatorcontrib>Man, Vojtěch</creatorcontrib><creatorcontrib>Vlachovský, Robert</creatorcontrib><creatorcontrib>Kubíček, Luboš</creatorcontrib><creatorcontrib>Kracík, Jan</creatorcontrib><creatorcontrib>Staffa, Robert</creatorcontrib><creatorcontrib>Novotný, Tomáš</creatorcontrib><creatorcontrib>Burša, Jiří</creatorcontrib><creatorcontrib>Raghavan, M.L.</creatorcontrib><title>Failure properties of abdominal aortic aneurysm tissue are orientation dependent</title><title>Journal of the mechanical behavior of biomedical materials</title><addtitle>J Mech Behav Biomed Mater</addtitle><description>Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study investigates the effect of sample orientation on failure properties.
Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength Pult and ultimate tension Tult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests.
Medians of Pult (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p < 10−4) and Tult (17.4 N/cm in circumferential vs. 11.2 N/cm in axial direction, p < 10−4) were significantly higher in circumferential direction. For paired data, the median of difference was 411 kPa (p < 10−3) in Pult and 7.4 N/cm (p < 10−4) in Tult in favor of circumferential direction.
In this first study of anisotropy in AAA wall failure properties using paired comparisons, the strength in circumferential orientation was found to be higher than in axial orientation.
[Display omitted]
•Failure properties of Abdominal aortic aneurysm studied.•45 patients; 90 samples in both axial and circumferential direction tested.•Data from 20 patients obtained in both directions for the first time.•Failure properties are significantly higher in circumferential direction.</description><subject>Abdominal aortic aneurysm</subject><subject>Anisotropy</subject><subject>Aortic Aneurysm, Abdominal</subject><subject>Aortic Rupture</subject><subject>Biomechanical Phenomena</subject><subject>Failure properties</subject><subject>Female</subject><subject>Humans</subject><subject>Mechanical testing</subject><subject>Risk Assessment</subject><subject>Sample orientation</subject><subject>Stress, Mechanical</subject><issn>1751-6161</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotlafQJBZupmaS5MmCxdSrAoFXeg6ZDInkDIzqcmM0Lc3Y6tLV-fC_5_Lh9A1wXOCibjbzrdtVbVziunYWRBJTtCUyKUsMZH4NOdLTkpBBJmgi5S2GAuMpTxHE8YIZ4ryKXpbG98MEYpdDDuIvYdUBFeYqg6t70xTmJCbtjAdDHGf2qL3KQ1QmGwJ0UPXm96HrqhhB12dy0t05kyT4OoYZ-hj_fi-ei43r08vq4dNaRlXfcmExXSBVcUVo0pQZ-mSC1kbKR2mwmEuHeeOqppQRqQjjAoljHLSKiGWlM3Q7WFuPvxzgNTr1icLTZMvDUPSdMElZlKoUcoOUhtDShGc3kXfmrjXBOsRpd7qH5R6RKkPKLPr5rhgqFqo_zy_7LLg_iCA_OaXh6iTzUAs1D6C7XUd_L8LvgH6lITM</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Polzer, Stanislav</creator><creator>Man, Vojtěch</creator><creator>Vlachovský, Robert</creator><creator>Kubíček, Luboš</creator><creator>Kracík, Jan</creator><creator>Staffa, Robert</creator><creator>Novotný, Tomáš</creator><creator>Burša, Jiří</creator><creator>Raghavan, M.L.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5439-2009</orcidid><orcidid>https://orcid.org/0000-0002-2960-185X</orcidid><orcidid>https://orcid.org/0000-0002-7092-9128</orcidid></search><sort><creationdate>202102</creationdate><title>Failure properties of abdominal aortic aneurysm tissue are orientation dependent</title><author>Polzer, Stanislav ; Man, Vojtěch ; Vlachovský, Robert ; Kubíček, Luboš ; Kracík, Jan ; Staffa, Robert ; Novotný, Tomáš ; Burša, Jiří ; Raghavan, M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-36c02409b5932962fc27568da88f026f058f55f29d12318f132696a9f8c966723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdominal aortic aneurysm</topic><topic>Anisotropy</topic><topic>Aortic Aneurysm, Abdominal</topic><topic>Aortic Rupture</topic><topic>Biomechanical Phenomena</topic><topic>Failure properties</topic><topic>Female</topic><topic>Humans</topic><topic>Mechanical testing</topic><topic>Risk Assessment</topic><topic>Sample orientation</topic><topic>Stress, Mechanical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Polzer, Stanislav</creatorcontrib><creatorcontrib>Man, Vojtěch</creatorcontrib><creatorcontrib>Vlachovský, Robert</creatorcontrib><creatorcontrib>Kubíček, Luboš</creatorcontrib><creatorcontrib>Kracík, Jan</creatorcontrib><creatorcontrib>Staffa, Robert</creatorcontrib><creatorcontrib>Novotný, Tomáš</creatorcontrib><creatorcontrib>Burša, Jiří</creatorcontrib><creatorcontrib>Raghavan, M.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Polzer, Stanislav</au><au>Man, Vojtěch</au><au>Vlachovský, Robert</au><au>Kubíček, Luboš</au><au>Kracík, Jan</au><au>Staffa, Robert</au><au>Novotný, Tomáš</au><au>Burša, Jiří</au><au>Raghavan, M.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure properties of abdominal aortic aneurysm tissue are orientation dependent</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><addtitle>J Mech Behav Biomed Mater</addtitle><date>2021-02</date><risdate>2021</risdate><volume>114</volume><spage>104181</spage><epage>104181</epage><pages>104181-104181</pages><artnum>104181</artnum><issn>1751-6161</issn><eissn>1878-0180</eissn><abstract>Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study investigates the effect of sample orientation on failure properties.
Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength Pult and ultimate tension Tult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests.
Medians of Pult (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p < 10−4) and Tult (17.4 N/cm in circumferential vs. 11.2 N/cm in axial direction, p < 10−4) were significantly higher in circumferential direction. For paired data, the median of difference was 411 kPa (p < 10−3) in Pult and 7.4 N/cm (p < 10−4) in Tult in favor of circumferential direction.
In this first study of anisotropy in AAA wall failure properties using paired comparisons, the strength in circumferential orientation was found to be higher than in axial orientation.
[Display omitted]
•Failure properties of Abdominal aortic aneurysm studied.•45 patients; 90 samples in both axial and circumferential direction tested.•Data from 20 patients obtained in both directions for the first time.•Failure properties are significantly higher in circumferential direction.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33153925</pmid><doi>10.1016/j.jmbbm.2020.104181</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5439-2009</orcidid><orcidid>https://orcid.org/0000-0002-2960-185X</orcidid><orcidid>https://orcid.org/0000-0002-7092-9128</orcidid></addata></record> |
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| subjects | Abdominal aortic aneurysm Anisotropy Aortic Aneurysm, Abdominal Aortic Rupture Biomechanical Phenomena Failure properties Female Humans Mechanical testing Risk Assessment Sample orientation Stress, Mechanical |
| title | Failure properties of abdominal aortic aneurysm tissue are orientation dependent |
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