“Breaking down” the mechanisms of expansion

“Breaking down” the mechanisms of expansion

In this issue of Blood, Subramaniam et al reveals that UM171 mechanistically facilitates expansion of human umbilical cord blood (UCB) hematopoietic stem cells (HSCs) by targeting the proteo-degradation of lysine-specific histone demethylase 1A (LSD1) and also targeting the RCOR1 subunit of CoREST.(...

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Veröffentlicht in:Blood 2020-11, Vol.136 (19), p.2095-2096
1. Verfasser: O'Leary, Heather A.
Format: Artikel
Sprache:eng
Schlagworte:
Hematology
Humans
Life Sciences & Biomedicine
Lysine
Science & Technology
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Zusammenfassung:In this issue of Blood, Subramaniam et al reveals that UM171 mechanistically facilitates expansion of human umbilical cord blood (UCB) hematopoietic stem cells (HSCs) by targeting the proteo-degradation of lysine-specific histone demethylase 1A (LSD1) and also targeting the RCOR1 subunit of CoREST.(1)
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2020007600