Pharmacogenetic profile and the development of the dyskinesia induced by levodopa-therapy in Parkinson’s disease patients: a population-based cohort study

Levodopa-induced dyskinesia (LID) is an adverse effect that negatively impacts the quality of life of patients with Parkinson’s disease (PD). Studies report that genetic variations in the genes of the pharmacogenetic pathway of the levodopa (L-DOPA) might be associated with LID development. The goal...

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Veröffentlicht in:	Molecular biology reports 2020-11, Vol.47 (11), p.8997-9004
Hauptverfasser:	dos Santos, Erinaldo Ubirajara Damasceno, da Silva, Isaura Isabelle Fonseca Gomes, Asano, Amdore Guescel C., Asano, Nadja Maria Jorge, De Mascena Diniz Maia, Maria, de Souza, Paulo Roberto Eleutério
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cohort analysis Dopamine D1 receptors Dopamine D2 receptors Dyskinesia Gene polymorphism Genetic diversity Genotype & phenotype Genotyping Histology Levodopa Life Sciences Morphology Movement disorders Neurodegenerative diseases Original Article Parkinson's disease Patients Population studies Population-based studies Quality of life Regression analysis Restriction fragment length polymorphism Risk factors
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