Bioorthogonal Activation of Dual Catalytic and Anti‐Cancer Activities of Organogold(I) Complexes in Living Systems

Controllably activating the bio‐reactivity of metal complexes in living systems is challenging but highly desirable because it can minimize off‐target bindings and improve spatiotemporal specificity. Herein, we report a new bioorthogonal activation approach by employing Pd(II)‐triggered transmetalla...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-02, Vol.60 (8), p.4133-4141
Hauptverfasser:	Long, Yan, Cao, Bei, Xiong, Xiaolin, Chan, Albert S. C., Sun, Raymond Wai‐Yin, Zou, Taotao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Angiogenesis Animals anti-cancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology bioorthogonal activation Cancer Catalysis Cell Line, Tumor Cell proliferation Cell Survival - drug effects Coordination Complexes - chemistry Coordination Complexes - metabolism Coordination Complexes - pharmacology Coordination compounds Danio rerio Density Functional Theory Embryo, Nonmammalian - chemistry Embryo, Nonmammalian - metabolism Fluorescence Gold - chemistry gold medicine Humans in-cell catalysis Metal complexes Methane - analogs & derivatives Methane - chemistry NMR Nuclear magnetic resonance Optical Imaging Palladium Palladium - chemistry Reductases thiol reactivity Thiols Thioredoxin Zebrafish Zebrafish - growth & development Zebrafish - metabolism
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