Uncovering Clinically Relevant Gene Fusions with Integrated Genomic and Transcriptomic Profiling of Metastatic Cancers

Gene fusions are important oncogenic drivers and many are actionable. Whole-genome and transcriptome (WGS and RNA-seq, respectively) sequencing can discover novel clinically relevant fusions. Using WGS and RNA-seq, we reviewed the prevalence of fusions in a cohort of 570 patients with cancer, and co...

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Veröffentlicht in:	Clinical cancer research 2021-01, Vol.27 (2), p.522-531
Hauptverfasser:	Tsang, Erica S, Grisdale, Cameron J, Pleasance, Erin, Topham, James T, Mungall, Karen, Reisle, Caralyn, Choo, Caleb, Carreira, Marcus, Bowlby, Reanne, Karasinska, Joanna M, MacMillan, Daniel, Williamson, Laura M, Chuah, Eric, Moore, Richard A, Mungall, Andrew J, Zhao, Yongjun, Tessier-Cloutier, Basile, Ng, Tony, Sun, Sophie, Lim, Howard J, Schaeffer, David F, Renouf, Daniel J, Yip, Stephen, Laskin, Janessa, Marra, Marco A, Jones, Steven J M, Loree, Jonathan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression Profiling - methods Gene Fusion Genomics - methods Humans Neoplasm Metastasis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Oncogene Proteins, Fusion - genetics Retrospective Studies RNA-Seq - methods Treatment Outcome Whole Exome Sequencing - methods
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