A highly potent maytansinoid analogue and its use as a cytotoxic therapeutic agent in gold nanoparticles for the treatment of hepatocellular carcinoma

[Display omitted] Gold nanoparticles are promising drug delivery agents with the potential to deliver chemotherapeutic agents to tumour sites. The highly cytotoxic maytansinoid tubulin inhibitor DM1 has been attached to gold nanoparticles and shows tumour growth inhibition in mouse models of hepatoc...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-12, Vol.30 (24), p.127634-127634, Article 127634
Hauptverfasser:	Porter, John, Ding, Yao, Hale, Sarah J.M., Perrins, Richard D., Robinson, Angela, Mazanetz, Michael P., Wu, Yubo, Ma, Yinping, Conlon, Kelly, Coulter, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapy DM1 Gold nanoparticles Heptocellular carcinoma Maytansine Nanomedicine Therapeutic cytotoxin
Online-Zugang:	Volltext
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