The QT Interval in Patients With the Turner Syndrome
•Patients with Turner syndrome have a longer corrected QT interval compared with matched controls.•Patients with Turner syndrome are commonly prescribed QTc prolonging medications.•Patients with Turner syndrome are not at greater risk for ventricular arrhythmias. Patients with the Turner syndrome (T...
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| Veröffentlicht in: | The American journal of cardiology 2021-02, Vol.140, p.118-121 |
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| container_title | The American journal of cardiology |
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| creator | Harrahill, Noah J. Yetman, Anji T. Danford, David A. Starr, Lois J. Sanmann, Jennifer N. Robinson, Jeffrey A. |
| description | •Patients with Turner syndrome have a longer corrected QT interval compared with matched controls.•Patients with Turner syndrome are commonly prescribed QTc prolonging medications.•Patients with Turner syndrome are not at greater risk for ventricular arrhythmias.
Patients with the Turner syndrome (TS) often have longer QT intervals compared with age-matched peers although the significance of this remains unknown. We sought to determine the degree, frequency and impact of QTc prolongation in patients with TS. A chart review of all patients with an electrocardiogram (ECG) and genetically proven TS was performed. Medications at the time of the ECG were reviewed and QTc calculated. Medications were classified according to QTc risk using www.crediblemeds.com. ECG parameters were compared with an age, gender, and cardiac lesion-matched control group. Over the 10-year period of review, 112 TS patients with a mean age of 34 ± 25 years underwent 226 ECGs. At least 1 QTc prolonging medication was prescribed in 81 (74%) patients. Longer QTc interval correlated with absence of y chromosomal material (p = 0.01), older age (p |
| doi_str_mv | 10.1016/j.amjcard.2020.09.061 |
| format | Article |
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Patients with the Turner syndrome (TS) often have longer QT intervals compared with age-matched peers although the significance of this remains unknown. We sought to determine the degree, frequency and impact of QTc prolongation in patients with TS. A chart review of all patients with an electrocardiogram (ECG) and genetically proven TS was performed. Medications at the time of the ECG were reviewed and QTc calculated. Medications were classified according to QTc risk using www.crediblemeds.com. ECG parameters were compared with an age, gender, and cardiac lesion-matched control group. Over the 10-year period of review, 112 TS patients with a mean age of 34 ± 25 years underwent 226 ECGs. At least 1 QTc prolonging medication was prescribed in 81 (74%) patients. Longer QTc interval correlated with absence of y chromosomal material (p = 0.01), older age (p <0.0001), increased number of QTc prolonging and nonprolonging medications (p <0.0001 each). During the 7.0 ± 5.1 years of follow-up, no patient had ventricular arrhythmia or unexplained sudden death. QTc was significantly shorter in matched controls using either Bazett or Hodges formula (424 ± 16 ms vs 448 ± 28 ms, p <0.0001; and 414.8 ± 16 ms vs 424.2 ± 20 ms; p = 0.0002, respectively). However, there was no difference in the frequency of QTc prolongation >460 msec (2.8% vs 2.6%, p = 0.9). In conclusion, despite frequent use of QT-prolonging medications, ventricular arrhythmias are rare in TS.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2020.09.061</identifier><identifier>PMID: 33144168</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age ; Arrhythmia ; Cardiac arrhythmia ; Cardiovascular disease ; Congenital diseases ; Coronary vessels ; EKG ; Electrocardiography ; Female ; Females ; Follow-Up Studies ; Genetic disorders ; Heart rate ; Heart Rate - physiology ; Humans ; Hypertension ; Liver diseases ; Long QT Syndrome - diagnosis ; Long QT Syndrome - etiology ; Long QT Syndrome - physiopathology ; Male ; Patients ; Prognosis ; Prolongation ; Retrospective Studies ; Turner Syndrome - complications ; Turner Syndrome - diagnosis ; Turner Syndrome - physiopathology ; Turner's syndrome ; Variables ; Ventricle ; Young Adult</subject><ispartof>The American journal of cardiology, 2021-02, Vol.140, p.118-121</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-92ee1238b5538d2670a0c38caec14d2a884c558a7d2fbc8a7fbe55e39649bd763</citedby><cites>FETCH-LOGICAL-c393t-92ee1238b5538d2670a0c38caec14d2a884c558a7d2fbc8a7fbe55e39649bd763</cites><orcidid>0000-0002-9212-2499 ; 0000-0003-0918-2755</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2475350492?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33144168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrahill, Noah J.</creatorcontrib><creatorcontrib>Yetman, Anji T.</creatorcontrib><creatorcontrib>Danford, David A.</creatorcontrib><creatorcontrib>Starr, Lois J.</creatorcontrib><creatorcontrib>Sanmann, Jennifer N.</creatorcontrib><creatorcontrib>Robinson, Jeffrey A.</creatorcontrib><title>The QT Interval in Patients With the Turner Syndrome</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>•Patients with Turner syndrome have a longer corrected QT interval compared with matched controls.•Patients with Turner syndrome are commonly prescribed QTc prolonging medications.•Patients with Turner syndrome are not at greater risk for ventricular arrhythmias.
Patients with the Turner syndrome (TS) often have longer QT intervals compared with age-matched peers although the significance of this remains unknown. We sought to determine the degree, frequency and impact of QTc prolongation in patients with TS. A chart review of all patients with an electrocardiogram (ECG) and genetically proven TS was performed. Medications at the time of the ECG were reviewed and QTc calculated. Medications were classified according to QTc risk using www.crediblemeds.com. ECG parameters were compared with an age, gender, and cardiac lesion-matched control group. Over the 10-year period of review, 112 TS patients with a mean age of 34 ± 25 years underwent 226 ECGs. At least 1 QTc prolonging medication was prescribed in 81 (74%) patients. Longer QTc interval correlated with absence of y chromosomal material (p = 0.01), older age (p <0.0001), increased number of QTc prolonging and nonprolonging medications (p <0.0001 each). During the 7.0 ± 5.1 years of follow-up, no patient had ventricular arrhythmia or unexplained sudden death. QTc was significantly shorter in matched controls using either Bazett or Hodges formula (424 ± 16 ms vs 448 ± 28 ms, p <0.0001; and 414.8 ± 16 ms vs 424.2 ± 20 ms; p = 0.0002, respectively). However, there was no difference in the frequency of QTc prolongation >460 msec (2.8% vs 2.6%, p = 0.9). In conclusion, despite frequent use of QT-prolonging medications, ventricular arrhythmias are rare in TS.</description><subject>Adult</subject><subject>Age</subject><subject>Arrhythmia</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Congenital diseases</subject><subject>Coronary vessels</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Genetic disorders</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Liver diseases</subject><subject>Long QT Syndrome - diagnosis</subject><subject>Long QT Syndrome - etiology</subject><subject>Long QT Syndrome - physiopathology</subject><subject>Male</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Prolongation</subject><subject>Retrospective Studies</subject><subject>Turner Syndrome - complications</subject><subject>Turner Syndrome - diagnosis</subject><subject>Turner Syndrome - physiopathology</subject><subject>Turner's syndrome</subject><subject>Variables</subject><subject>Ventricle</subject><subject>Young Adult</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkMtKw0AUhgdRbK0-ghJw4yZxrklmJVK8FAoqVlwOk5kTmpBLnUkLfXuntLpw4-rnwHfO-fkQuiQ4IZikt3Wi29poZxOKKU6wTHBKjtCY5JmMiSTsGI0xxjSWhMsROvO-DiMhIj1FI8YI5yTNx4gvlhC9LaJZN4Db6CaquuhVDxV0g48-q2EZDQFYrF0HLnrfdtb1LZyjk1I3Hi4OOUEfjw-L6XM8f3maTe_nsWGSDbGkAISyvBCC5ZamGdbYsNxoMIRbqvOcGyFynVlaFiZkWYAQwGTKZWGzlE3Qzf7uyvVfa_CDaitvoGl0B_3aK8pFlkqSYRbQ6z9o3YfSoV2gMsEE5pIGSuwp43rvHZRq5apWu60iWO20qlodtKqdVoWlClrD3tXh-rpowf5u_XgMwN0egKBjU4FT3gSHBmzlwAzK9tU_L74BdNeI2Q</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Harrahill, Noah J.</creator><creator>Yetman, Anji T.</creator><creator>Danford, David A.</creator><creator>Starr, Lois J.</creator><creator>Sanmann, Jennifer N.</creator><creator>Robinson, Jeffrey A.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9212-2499</orcidid><orcidid>https://orcid.org/0000-0003-0918-2755</orcidid></search><sort><creationdate>20210201</creationdate><title>The QT Interval in Patients With the Turner Syndrome</title><author>Harrahill, Noah J. ; Yetman, Anji T. ; Danford, David A. ; Starr, Lois J. ; Sanmann, Jennifer N. ; Robinson, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-92ee1238b5538d2670a0c38caec14d2a884c558a7d2fbc8a7fbe55e39649bd763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Age</topic><topic>Arrhythmia</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Congenital diseases</topic><topic>Coronary vessels</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Genetic disorders</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Liver diseases</topic><topic>Long QT Syndrome - diagnosis</topic><topic>Long QT Syndrome - etiology</topic><topic>Long QT Syndrome - physiopathology</topic><topic>Male</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Prolongation</topic><topic>Retrospective Studies</topic><topic>Turner Syndrome - complications</topic><topic>Turner Syndrome - diagnosis</topic><topic>Turner Syndrome - physiopathology</topic><topic>Turner's syndrome</topic><topic>Variables</topic><topic>Ventricle</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrahill, Noah J.</creatorcontrib><creatorcontrib>Yetman, Anji T.</creatorcontrib><creatorcontrib>Danford, David A.</creatorcontrib><creatorcontrib>Starr, Lois J.</creatorcontrib><creatorcontrib>Sanmann, Jennifer N.</creatorcontrib><creatorcontrib>Robinson, Jeffrey A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrahill, Noah J.</au><au>Yetman, Anji T.</au><au>Danford, David A.</au><au>Starr, Lois J.</au><au>Sanmann, Jennifer N.</au><au>Robinson, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The QT Interval in Patients With the Turner Syndrome</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>140</volume><spage>118</spage><epage>121</epage><pages>118-121</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>•Patients with Turner syndrome have a longer corrected QT interval compared with matched controls.•Patients with Turner syndrome are commonly prescribed QTc prolonging medications.•Patients with Turner syndrome are not at greater risk for ventricular arrhythmias.
Patients with the Turner syndrome (TS) often have longer QT intervals compared with age-matched peers although the significance of this remains unknown. We sought to determine the degree, frequency and impact of QTc prolongation in patients with TS. A chart review of all patients with an electrocardiogram (ECG) and genetically proven TS was performed. Medications at the time of the ECG were reviewed and QTc calculated. Medications were classified according to QTc risk using www.crediblemeds.com. ECG parameters were compared with an age, gender, and cardiac lesion-matched control group. Over the 10-year period of review, 112 TS patients with a mean age of 34 ± 25 years underwent 226 ECGs. At least 1 QTc prolonging medication was prescribed in 81 (74%) patients. Longer QTc interval correlated with absence of y chromosomal material (p = 0.01), older age (p <0.0001), increased number of QTc prolonging and nonprolonging medications (p <0.0001 each). During the 7.0 ± 5.1 years of follow-up, no patient had ventricular arrhythmia or unexplained sudden death. QTc was significantly shorter in matched controls using either Bazett or Hodges formula (424 ± 16 ms vs 448 ± 28 ms, p <0.0001; and 414.8 ± 16 ms vs 424.2 ± 20 ms; p = 0.0002, respectively). However, there was no difference in the frequency of QTc prolongation >460 msec (2.8% vs 2.6%, p = 0.9). In conclusion, despite frequent use of QT-prolonging medications, ventricular arrhythmias are rare in TS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33144168</pmid><doi>10.1016/j.amjcard.2020.09.061</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9212-2499</orcidid><orcidid>https://orcid.org/0000-0003-0918-2755</orcidid></addata></record> |
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| subjects | Adult Age Arrhythmia Cardiac arrhythmia Cardiovascular disease Congenital diseases Coronary vessels EKG Electrocardiography Female Females Follow-Up Studies Genetic disorders Heart rate Heart Rate - physiology Humans Hypertension Liver diseases Long QT Syndrome - diagnosis Long QT Syndrome - etiology Long QT Syndrome - physiopathology Male Patients Prognosis Prolongation Retrospective Studies Turner Syndrome - complications Turner Syndrome - diagnosis Turner Syndrome - physiopathology Turner's syndrome Variables Ventricle Young Adult |
| title | The QT Interval in Patients With the Turner Syndrome |
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