The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis
Vitamin C (ascorbic acid) is a water-soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-sur...
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| Veröffentlicht in: | British journal of nutrition 2022-01, Vol.127 (2), p.233-247 |
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| creator | Travica, N. Ried, K. Hudson, I. Scholey, A. Pipingas, A. Sali, A. |
| description | Vitamin C (ascorbic acid) is a water-soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of −17·99 µmol/l (39 % depletion) (CI −22·81, −13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and −18·80 µmol/l (21 % depletion) (CI −25·04, −12·56) (trial arms = 6, n 166, P < 0·001) 2–3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology. |
| doi_str_mv | 10.1017/S0007114520004353 |
| format | Article |
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A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of −17·99 µmol/l (39 % depletion) (CI −22·81, −13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and −18·80 µmol/l (21 % depletion) (CI −25·04, −12·56) (trial arms = 6, n 166, P < 0·001) 2–3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114520004353</identifier><identifier>PMID: 33143761</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Ascorbic Acid ; Bias ; Bioavailability ; Chronic illnesses ; Clinical trials ; Data analysis ; Depletion ; Heterogeneity ; Human and Clinical Nutrition ; Humans ; Intervention ; Investigations ; Meta-analysis ; Physiology ; Plasma ; Prospective Studies ; Scientific papers ; Standard deviation ; Subgroups ; Surgery ; Symptomology ; Systematic review ; Systematic Review and Meta-Analysis ; Trauma ; Vitamin C ; Vitamins</subject><ispartof>British journal of nutrition, 2022-01, Vol.127 (2), p.233-247</ispartof><rights>The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-ed2dc64338bd354b569f25975689f01bfcf8de66ca490767230fec80c4d32a403</citedby><cites>FETCH-LOGICAL-c416t-ed2dc64338bd354b569f25975689f01bfcf8de66ca490767230fec80c4d32a403</cites><orcidid>0000-0003-1841-3017</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114520004353/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,782,786,27933,27934,55637</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33143761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Travica, N.</creatorcontrib><creatorcontrib>Ried, K.</creatorcontrib><creatorcontrib>Hudson, I.</creatorcontrib><creatorcontrib>Scholey, A.</creatorcontrib><creatorcontrib>Pipingas, A.</creatorcontrib><creatorcontrib>Sali, A.</creatorcontrib><title>The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Vitamin C (ascorbic acid) is a water-soluble vitamin with an array of biological functions. A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of −17·99 µmol/l (39 % depletion) (CI −22·81, −13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and −18·80 µmol/l (21 % depletion) (CI −25·04, −12·56) (trial arms = 6, n 166, P < 0·001) 2–3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology.</description><subject>Ascorbic Acid</subject><subject>Bias</subject><subject>Bioavailability</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Data analysis</subject><subject>Depletion</subject><subject>Heterogeneity</subject><subject>Human and Clinical Nutrition</subject><subject>Humans</subject><subject>Intervention</subject><subject>Investigations</subject><subject>Meta-analysis</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Scientific papers</subject><subject>Standard deviation</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Symptomology</subject><subject>Systematic review</subject><subject>Systematic Review and Meta-Analysis</subject><subject>Trauma</subject><subject>Vitamin C</subject><subject>Vitamins</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUtr3DAQgEVpaTbb_oBeiqCXXJzVy5KdW1jygoUesjkbWR5tHCx7q7E37L-vlt200FB0kIb55ptBQ8g3zi4542bxyBgznKtcpIeSufxAZlyZPBNai49kdkhnh_wZOUd8SWHBWfmZnEnJlTSaz4hfPwMF78GNSAdPcYobiHs69HTbWQx2gRCnQHftaEPb0yV1Q--gH6Md26HHK2op7nGEkGJHI-xaeKW2b2iA0Wa2t90eW_xCPnnbIXw93XPydHuzXt5nq593D8vrVeYU12MGjWicVlIWdSNzVee69CIvTa6L0jNee-eLBrR2VpXMaCMkS5MXzKlGCquYnJOLo3cbh18T4FiFFh10ne1hmLASKjfJJUqT0B__oC_DFNO8idK8MOlonSh-pFwcECP4ahvbYOO-4qw6LKF6t4RU8_1knuoAzZ-Kt19PgDxJbahj22zgb-__a38DGvGQgw</recordid><startdate>20220128</startdate><enddate>20220128</enddate><creator>Travica, N.</creator><creator>Ried, K.</creator><creator>Hudson, I.</creator><creator>Scholey, A.</creator><creator>Pipingas, A.</creator><creator>Sali, A.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1841-3017</orcidid></search><sort><creationdate>20220128</creationdate><title>The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis</title><author>Travica, N. ; 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A number of proposed factors contribute to the vitamin’s plasma bioavailability and ability to exert optimal functionality. The aim of this review was to systematically assess plasma vitamin C levels post-surgery compared with pre-surgery/the magnitude and time frame of potential changes in concentration. We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases between 1970 and April 2020 for relevant research papers. Prospective studies, control groups and true placebo groups derived from controlled trials that reported means and standard deviations of plasma vitamin C concentrations pre- and postoperatively were included into the meta-analysis. Data were grouped into short-term (≤7 d) and long-term (>7 d) postoperative follow-up. Twenty-three of thirty-one studies involving 642 patients included in the systematic review were suitable for meta-analysis. Pooled data from the meta-analysis revealed a mean depletion of plasma vitamin C concentration of −17·99 µmol/l (39 % depletion) (CI −22·81, −13·17) (trial arms = 25, n 565, P < 0·001) during the first postoperative week and −18·80 µmol/l (21 % depletion) (CI −25·04, −12·56) (trial arms = 6, n 166, P < 0·001) 2–3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery; however, high heterogeneity was observed amongst trials assessing concentration change during the first postoperative week. Overall, our results warrant larger, long-term investigations of changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>33143761</pmid><doi>10.1017/S0007114520004353</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-1841-3017</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ascorbic Acid Bias Bioavailability Chronic illnesses Clinical trials Data analysis Depletion Heterogeneity Human and Clinical Nutrition Humans Intervention Investigations Meta-analysis Physiology Plasma Prospective Studies Scientific papers Standard deviation Subgroups Surgery Symptomology Systematic review Systematic Review and Meta-Analysis Trauma Vitamin C Vitamins |
| title | The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis |
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