Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition

Protease-activated receptor 2 (PAR2) regulates inflammatory responses and lipid metabolism. However, its precise role in colitis remains unclear. In this study, we aimed to investigate the function of PAR2 in high-fat diet-fed mice with colitis and its potential role in autophagy. and mice were fed...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2021-01, Vol.320 (1), p.G30-G42
Hauptverfasser:	Her, Ji Yun, Lee, Yunna, Kim, Su Jin, Heo, Gwangbeom, Choo, Jieun, Kim, Yuju, Howe, Cody, Rhee, Sang Hoon, Yu, Hak Sun, Chung, Hae Young, Pothoulakis, Charalabos, Im, Eunok
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Body weight Body weight loss Caspase-3 Caspase-9 Colitis Colon Colon - drug effects Colon - metabolism Cytokines Cytokines - metabolism Dextran Dextran Sulfate - pharmacology Diarrhea Diet, High-Fat - adverse effects High fat diet Inflammation - drug therapy Inflammatory bowel disease Inflammatory bowel diseases Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Lipid metabolism Metabolic syndrome Mitochondria Mucosa Palmitic acid Phagocytosis Poly(ADP-ribose) Poly(ADP-ribose) polymerase Receptor, PAR-2 - drug effects Receptor, PAR-2 - metabolism Ribose SIRT1 protein Sodium sulfate Therapeutic targets Yes-associated protein
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