Epidemiology of invasive fungal disease in haematologic patients
Invasive fungal disease (IFD) is frequent in patients with haematologic malignancies and in recipients of haematopoietic cell transplantation (HCT). An epidemiologic study conducted in Brazil reported a high incidence of IFD in haematologic patients, and invasive fusariosis was the leading IFD. A li...
Gespeichert in:
Veröffentlicht in: | Mycoses 2021-03, Vol.64 (3), p.252-256 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 256 |
---|---|
container_issue | 3 |
container_start_page | 252 |
container_title | Mycoses |
container_volume | 64 |
creator | Souza, Luciana Nouér, Simone A. Morales, Hugo Simões, Belinda Solza, Cristiana Queiroz‐Telles, Flavio Nucci, Marcio |
description | Invasive fungal disease (IFD) is frequent in patients with haematologic malignancies and in recipients of haematopoietic cell transplantation (HCT). An epidemiologic study conducted in Brazil reported a high incidence of IFD in haematologic patients, and invasive fusariosis was the leading IFD. A limitation of that study was that galactomannan was not available for at least half of the study period. In order to characterise the epidemiology and burden of IFD in three cohorts, HCT, acute myeloid leukaemia (AML) or myelodysplasia (MDS), and acute lymphoid leukaemia (ALL), we conducted a prospective multicentre cohort study in four haematologic Brazilian centres. From August 2015 to July 2016, all patients receiving induction chemotherapy for newly diagnosed or relapsed AML, MDS or ALL, and all HCT recipients receiving conditioning regimen were followed during the period of neutropenia following chemotherapy or the conditioning regimen. During a 1‐year period, 192 patients were enrolled: 122 HCT recipients (71 allogeneic, 51 autologous), 46 with AML, and 24 with ALL. The global incidence of IFD was 13.0% (25 cases, 11 proven and 14 probable). Invasive aspergillosis (14 cases) was the leading IFD, followed by candidemia (6 cases) and fusariosis (3 cases). The incidence of IFD was 26.1% in AML/MDS, 16.7% in ALL, 11.3% in allogeneic HCT, and 2.0% in autologous HCT. The burden of IFD in haematologic patients in Brazil is high, with a higher frequency in AML and ALL. Invasive aspergillosis is the leading IFD, followed by invasive candidiasis and fusariosis. |
doi_str_mv | 10.1111/myc.13205 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2457663017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2488129294</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-56329f52025b213ad30ea173f69b70119f23cc521fb11a1239094cd957f969b3</originalsourceid><addsrcrecordid>eNp10E1LwzAYB_AgipvTg19ACl700C1P0jTLTRnzBSZedvFU0jSZGX2zaSf99mZ2ehDM5YHw48_z_BG6BDwF_2ZFr6ZACWZHaAwRFSFmmB-jMRaUhjzCfITOnNtiDFyQ-BSNKIUIRCzG6G5Z20wXtsqrTR9UJrDlTjq704Hpyo3Mg8w6LZ32_8G71IVs99KqoJat1WXrztGJkbnTF4c5QeuH5XrxFK5eH58X96tQUUZZyGJKhGEEE5YSoDKjWEvg1MQi5RhAGEKVYgRMCiCBUIFFpDLBuPF7pnSCbobYuqk-Ou3apLBO6TyXpa46l5CI8Tim_kJPr__QbdU1pV_Oq_kciCAi8up2UKqpnGu0SerGFrLpE8DJvtXEt5p8t-rt1SGxSwud_cqfGj2YDeDT5rr_Pyl5eVsMkV_X-37B</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2488129294</pqid></control><display><type>article</type><title>Epidemiology of invasive fungal disease in haematologic patients</title><source>Wiley Online Library - AutoHoldings Journals</source><creator>Souza, Luciana ; Nouér, Simone A. ; Morales, Hugo ; Simões, Belinda ; Solza, Cristiana ; Queiroz‐Telles, Flavio ; Nucci, Marcio</creator><creatorcontrib>Souza, Luciana ; Nouér, Simone A. ; Morales, Hugo ; Simões, Belinda ; Solza, Cristiana ; Queiroz‐Telles, Flavio ; Nucci, Marcio</creatorcontrib><description>Invasive fungal disease (IFD) is frequent in patients with haematologic malignancies and in recipients of haematopoietic cell transplantation (HCT). An epidemiologic study conducted in Brazil reported a high incidence of IFD in haematologic patients, and invasive fusariosis was the leading IFD. A limitation of that study was that galactomannan was not available for at least half of the study period. In order to characterise the epidemiology and burden of IFD in three cohorts, HCT, acute myeloid leukaemia (AML) or myelodysplasia (MDS), and acute lymphoid leukaemia (ALL), we conducted a prospective multicentre cohort study in four haematologic Brazilian centres. From August 2015 to July 2016, all patients receiving induction chemotherapy for newly diagnosed or relapsed AML, MDS or ALL, and all HCT recipients receiving conditioning regimen were followed during the period of neutropenia following chemotherapy or the conditioning regimen. During a 1‐year period, 192 patients were enrolled: 122 HCT recipients (71 allogeneic, 51 autologous), 46 with AML, and 24 with ALL. The global incidence of IFD was 13.0% (25 cases, 11 proven and 14 probable). Invasive aspergillosis (14 cases) was the leading IFD, followed by candidemia (6 cases) and fusariosis (3 cases). The incidence of IFD was 26.1% in AML/MDS, 16.7% in ALL, 11.3% in allogeneic HCT, and 2.0% in autologous HCT. The burden of IFD in haematologic patients in Brazil is high, with a higher frequency in AML and ALL. Invasive aspergillosis is the leading IFD, followed by invasive candidiasis and fusariosis.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/myc.13205</identifier><identifier>PMID: 33141969</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acute lymphoblastic leukemia ; acute lymphoid leukaemia ; acute myeloid leukaemia ; Acute myeloid leukemia ; Aspergillosis ; Autografts ; Candidemia ; Candidiasis ; Chemotherapy ; Epidemiology ; Fungal diseases ; Fusariosis ; haematopoietic cell transplantation ; incidence ; invasive fungal disease ; Leukemia ; Myelodysplastic syndrome ; Neutropenia ; Transplantation</subject><ispartof>Mycoses, 2021-03, Vol.64 (3), p.252-256</ispartof><rights>2020 Wiley‐VCH GmbH</rights><rights>2020 Wiley-VCH GmbH.</rights><rights>2021 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-56329f52025b213ad30ea173f69b70119f23cc521fb11a1239094cd957f969b3</citedby><cites>FETCH-LOGICAL-c3535-56329f52025b213ad30ea173f69b70119f23cc521fb11a1239094cd957f969b3</cites><orcidid>0000-0001-7913-8958 ; 0000-0003-4867-0014</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmyc.13205$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmyc.13205$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33141969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza, Luciana</creatorcontrib><creatorcontrib>Nouér, Simone A.</creatorcontrib><creatorcontrib>Morales, Hugo</creatorcontrib><creatorcontrib>Simões, Belinda</creatorcontrib><creatorcontrib>Solza, Cristiana</creatorcontrib><creatorcontrib>Queiroz‐Telles, Flavio</creatorcontrib><creatorcontrib>Nucci, Marcio</creatorcontrib><title>Epidemiology of invasive fungal disease in haematologic patients</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Invasive fungal disease (IFD) is frequent in patients with haematologic malignancies and in recipients of haematopoietic cell transplantation (HCT). An epidemiologic study conducted in Brazil reported a high incidence of IFD in haematologic patients, and invasive fusariosis was the leading IFD. A limitation of that study was that galactomannan was not available for at least half of the study period. In order to characterise the epidemiology and burden of IFD in three cohorts, HCT, acute myeloid leukaemia (AML) or myelodysplasia (MDS), and acute lymphoid leukaemia (ALL), we conducted a prospective multicentre cohort study in four haematologic Brazilian centres. From August 2015 to July 2016, all patients receiving induction chemotherapy for newly diagnosed or relapsed AML, MDS or ALL, and all HCT recipients receiving conditioning regimen were followed during the period of neutropenia following chemotherapy or the conditioning regimen. During a 1‐year period, 192 patients were enrolled: 122 HCT recipients (71 allogeneic, 51 autologous), 46 with AML, and 24 with ALL. The global incidence of IFD was 13.0% (25 cases, 11 proven and 14 probable). Invasive aspergillosis (14 cases) was the leading IFD, followed by candidemia (6 cases) and fusariosis (3 cases). The incidence of IFD was 26.1% in AML/MDS, 16.7% in ALL, 11.3% in allogeneic HCT, and 2.0% in autologous HCT. The burden of IFD in haematologic patients in Brazil is high, with a higher frequency in AML and ALL. Invasive aspergillosis is the leading IFD, followed by invasive candidiasis and fusariosis.</description><subject>Acute lymphoblastic leukemia</subject><subject>acute lymphoid leukaemia</subject><subject>acute myeloid leukaemia</subject><subject>Acute myeloid leukemia</subject><subject>Aspergillosis</subject><subject>Autografts</subject><subject>Candidemia</subject><subject>Candidiasis</subject><subject>Chemotherapy</subject><subject>Epidemiology</subject><subject>Fungal diseases</subject><subject>Fusariosis</subject><subject>haematopoietic cell transplantation</subject><subject>incidence</subject><subject>invasive fungal disease</subject><subject>Leukemia</subject><subject>Myelodysplastic syndrome</subject><subject>Neutropenia</subject><subject>Transplantation</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10E1LwzAYB_AgipvTg19ACl700C1P0jTLTRnzBSZedvFU0jSZGX2zaSf99mZ2ehDM5YHw48_z_BG6BDwF_2ZFr6ZACWZHaAwRFSFmmB-jMRaUhjzCfITOnNtiDFyQ-BSNKIUIRCzG6G5Z20wXtsqrTR9UJrDlTjq704Hpyo3Mg8w6LZ32_8G71IVs99KqoJat1WXrztGJkbnTF4c5QeuH5XrxFK5eH58X96tQUUZZyGJKhGEEE5YSoDKjWEvg1MQi5RhAGEKVYgRMCiCBUIFFpDLBuPF7pnSCbobYuqk-Ou3apLBO6TyXpa46l5CI8Tim_kJPr__QbdU1pV_Oq_kciCAi8up2UKqpnGu0SerGFrLpE8DJvtXEt5p8t-rt1SGxSwud_cqfGj2YDeDT5rr_Pyl5eVsMkV_X-37B</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Souza, Luciana</creator><creator>Nouér, Simone A.</creator><creator>Morales, Hugo</creator><creator>Simões, Belinda</creator><creator>Solza, Cristiana</creator><creator>Queiroz‐Telles, Flavio</creator><creator>Nucci, Marcio</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7913-8958</orcidid><orcidid>https://orcid.org/0000-0003-4867-0014</orcidid></search><sort><creationdate>202103</creationdate><title>Epidemiology of invasive fungal disease in haematologic patients</title><author>Souza, Luciana ; Nouér, Simone A. ; Morales, Hugo ; Simões, Belinda ; Solza, Cristiana ; Queiroz‐Telles, Flavio ; Nucci, Marcio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-56329f52025b213ad30ea173f69b70119f23cc521fb11a1239094cd957f969b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>acute lymphoid leukaemia</topic><topic>acute myeloid leukaemia</topic><topic>Acute myeloid leukemia</topic><topic>Aspergillosis</topic><topic>Autografts</topic><topic>Candidemia</topic><topic>Candidiasis</topic><topic>Chemotherapy</topic><topic>Epidemiology</topic><topic>Fungal diseases</topic><topic>Fusariosis</topic><topic>haematopoietic cell transplantation</topic><topic>incidence</topic><topic>invasive fungal disease</topic><topic>Leukemia</topic><topic>Myelodysplastic syndrome</topic><topic>Neutropenia</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Souza, Luciana</creatorcontrib><creatorcontrib>Nouér, Simone A.</creatorcontrib><creatorcontrib>Morales, Hugo</creatorcontrib><creatorcontrib>Simões, Belinda</creatorcontrib><creatorcontrib>Solza, Cristiana</creatorcontrib><creatorcontrib>Queiroz‐Telles, Flavio</creatorcontrib><creatorcontrib>Nucci, Marcio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Souza, Luciana</au><au>Nouér, Simone A.</au><au>Morales, Hugo</au><au>Simões, Belinda</au><au>Solza, Cristiana</au><au>Queiroz‐Telles, Flavio</au><au>Nucci, Marcio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of invasive fungal disease in haematologic patients</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2021-03</date><risdate>2021</risdate><volume>64</volume><issue>3</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Invasive fungal disease (IFD) is frequent in patients with haematologic malignancies and in recipients of haematopoietic cell transplantation (HCT). An epidemiologic study conducted in Brazil reported a high incidence of IFD in haematologic patients, and invasive fusariosis was the leading IFD. A limitation of that study was that galactomannan was not available for at least half of the study period. In order to characterise the epidemiology and burden of IFD in three cohorts, HCT, acute myeloid leukaemia (AML) or myelodysplasia (MDS), and acute lymphoid leukaemia (ALL), we conducted a prospective multicentre cohort study in four haematologic Brazilian centres. From August 2015 to July 2016, all patients receiving induction chemotherapy for newly diagnosed or relapsed AML, MDS or ALL, and all HCT recipients receiving conditioning regimen were followed during the period of neutropenia following chemotherapy or the conditioning regimen. During a 1‐year period, 192 patients were enrolled: 122 HCT recipients (71 allogeneic, 51 autologous), 46 with AML, and 24 with ALL. The global incidence of IFD was 13.0% (25 cases, 11 proven and 14 probable). Invasive aspergillosis (14 cases) was the leading IFD, followed by candidemia (6 cases) and fusariosis (3 cases). The incidence of IFD was 26.1% in AML/MDS, 16.7% in ALL, 11.3% in allogeneic HCT, and 2.0% in autologous HCT. The burden of IFD in haematologic patients in Brazil is high, with a higher frequency in AML and ALL. Invasive aspergillosis is the leading IFD, followed by invasive candidiasis and fusariosis.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33141969</pmid><doi>10.1111/myc.13205</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7913-8958</orcidid><orcidid>https://orcid.org/0000-0003-4867-0014</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0933-7407 |
ispartof | Mycoses, 2021-03, Vol.64 (3), p.252-256 |
issn | 0933-7407 1439-0507 |
language | eng |
recordid | cdi_proquest_miscellaneous_2457663017 |
source | Wiley Online Library - AutoHoldings Journals |
subjects | Acute lymphoblastic leukemia acute lymphoid leukaemia acute myeloid leukaemia Acute myeloid leukemia Aspergillosis Autografts Candidemia Candidiasis Chemotherapy Epidemiology Fungal diseases Fusariosis haematopoietic cell transplantation incidence invasive fungal disease Leukemia Myelodysplastic syndrome Neutropenia Transplantation |
title | Epidemiology of invasive fungal disease in haematologic patients |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T15%3A03%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiology%20of%20invasive%20fungal%20disease%20in%20haematologic%20patients&rft.jtitle=Mycoses&rft.au=Souza,%20Luciana&rft.date=2021-03&rft.volume=64&rft.issue=3&rft.spage=252&rft.epage=256&rft.pages=252-256&rft.issn=0933-7407&rft.eissn=1439-0507&rft_id=info:doi/10.1111/myc.13205&rft_dat=%3Cproquest_cross%3E2488129294%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2488129294&rft_id=info:pmid/33141969&rfr_iscdi=true |