Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment

BACKGROUND:The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatmen...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2020-12, Vol.85 (4), p.517-524
Hauptverfasser:	Thorball, Christian W., Borghesi, Alessandro, Bachmann, Nadine, Von Siebenthal, Chantal, Vongrad, Valentina, Turk, Teja, Neumann, Kathrin, Beerenwinkel, Niko, Bogojeska, Jasmina, Roth, Volker, Kok, Yik Lim, Parbhoo, Sonali, Wieser, Mario, Böni, Jürg, Perreau, Matthieu, Klimkait, Thomas, Yerly, Sabine, Battegay, Manuel, Rauch, Andri, Schmid, Patrick, Bernasconi, Enos, Cavassini, Matthias, Kouyos, Roger D., Günthard, Huldrych F., Metzner, Karin J., Fellay, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Copy number Decay Decay rate Deoxyribonucleic acid DNA Eradication Genetic diversity Genetic Predisposition to Disease Genetic variance Genetic Variation Genetics Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics - methods Genotype Genotyping HIV HIV Infections - drug therapy HIV Infections - genetics HIV-1 Human immunodeficiency virus Humans Leukocytes (mononuclear) Peripheral blood mononuclear cells Phenotypic variations Time Factors
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