Tissue engineering solutions to replace contractile function during pediatric heart surgery
•Pediatric heart sugery remains challenging.•New tools are needed to tackle this enormous challenge.•Bioengineered heart muscle, ventricles, Fontan pumps and hearts can be used in pediatric heart surgery.•This technology can prove to be game-changer in the field of pediatric heart surgery. Pediatric...
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| Veröffentlicht in: | Tissue & cell 2020-12, Vol.67, p.101452-101452, Article 101452 |
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| creator | Williams, Stuart K. Birla, Ravi K. |
| description | •Pediatric heart sugery remains challenging.•New tools are needed to tackle this enormous challenge.•Bioengineered heart muscle, ventricles, Fontan pumps and hearts can be used in pediatric heart surgery.•This technology can prove to be game-changer in the field of pediatric heart surgery.
Pediatric heart surgery remains challenging due to the small size of the pediatric heart, the severity of congenital abnormalities and the unique characteristics of each case. New tools and technologies are needed to tackle this enormous challenge. Tissue engineering strategies are focused on fabricating contractile heart muscle, ventricles, Fontan pumps and whole hearts, and a transplantable tissue equivalent has tremendous implications in pediatric heart surgery to provide functional cardiac tissue. This technology will prove to be a game-changer in the field of pediatric heart surgery and provide a novel toolkit for pediatric heart surgeons. This review will provide insight into the potential applications of tissue engineering technologies to replace lost contractile function in pediatric patients with heart abnormalities. |
| doi_str_mv | 10.1016/j.tice.2020.101452 |
| format | Article |
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Pediatric heart surgery remains challenging due to the small size of the pediatric heart, the severity of congenital abnormalities and the unique characteristics of each case. New tools and technologies are needed to tackle this enormous challenge. Tissue engineering strategies are focused on fabricating contractile heart muscle, ventricles, Fontan pumps and whole hearts, and a transplantable tissue equivalent has tremendous implications in pediatric heart surgery to provide functional cardiac tissue. This technology will prove to be a game-changer in the field of pediatric heart surgery and provide a novel toolkit for pediatric heart surgeons. This review will provide insight into the potential applications of tissue engineering technologies to replace lost contractile function in pediatric patients with heart abnormalities.</description><identifier>ISSN: 0040-8166</identifier><identifier>EISSN: 1532-3072</identifier><identifier>DOI: 10.1016/j.tice.2020.101452</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Abnormalities ; Cardiac muscle ; Fontan pumps ; Heart ; Heart surgery ; Heart transplantation ; HLHS ; Muscle contraction ; Muscles ; Pediatric heart surgery ; Pediatrics ; Single ventricle ; Surgery ; Tissue engineering ; Toolkits</subject><ispartof>Tissue & cell, 2020-12, Vol.67, p.101452-101452, Article 101452</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright Elsevier Science Ltd. Dec 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-64a844ba349d3f07cf5fddc404a53f133a968f049a9d4974e24ca7a5289cbcda3</citedby><cites>FETCH-LOGICAL-c361t-64a844ba349d3f07cf5fddc404a53f133a968f049a9d4974e24ca7a5289cbcda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0040816620306108$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Williams, Stuart K.</creatorcontrib><creatorcontrib>Birla, Ravi K.</creatorcontrib><title>Tissue engineering solutions to replace contractile function during pediatric heart surgery</title><title>Tissue & cell</title><description>•Pediatric heart sugery remains challenging.•New tools are needed to tackle this enormous challenge.•Bioengineered heart muscle, ventricles, Fontan pumps and hearts can be used in pediatric heart surgery.•This technology can prove to be game-changer in the field of pediatric heart surgery.
Pediatric heart surgery remains challenging due to the small size of the pediatric heart, the severity of congenital abnormalities and the unique characteristics of each case. New tools and technologies are needed to tackle this enormous challenge. Tissue engineering strategies are focused on fabricating contractile heart muscle, ventricles, Fontan pumps and whole hearts, and a transplantable tissue equivalent has tremendous implications in pediatric heart surgery to provide functional cardiac tissue. This technology will prove to be a game-changer in the field of pediatric heart surgery and provide a novel toolkit for pediatric heart surgeons. This review will provide insight into the potential applications of tissue engineering technologies to replace lost contractile function in pediatric patients with heart abnormalities.</description><subject>Abnormalities</subject><subject>Cardiac muscle</subject><subject>Fontan pumps</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Heart transplantation</subject><subject>HLHS</subject><subject>Muscle contraction</subject><subject>Muscles</subject><subject>Pediatric heart surgery</subject><subject>Pediatrics</subject><subject>Single ventricle</subject><subject>Surgery</subject><subject>Tissue engineering</subject><subject>Toolkits</subject><issn>0040-8166</issn><issn>1532-3072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQQIMoWKt_wFPAi5et-drNLniR4hcIXurJQ0hnZ2vKNqlJVui_d2s9efAUGN4bJo-QS85mnPHqZj3LDnAmmPgZqFIckQkvpSgk0-KYTBhTrKh5VZ2Ss5TWjDGtuJ6Q94VLaUCKfuU8YnR-RVPoh-yCTzQHGnHbW0AKwedoIbseaTd42AO0HX6ELbbO5uiAfqCNmaYhrjDuzslJZ_uEF7_vlLw93C_mT8XL6-Pz_O6lAFnxXFTK1kotrVRNKzumoSu7tgXFlC1lx6W0TVV3TDW2aVWjFQoFVttS1A0sobVySq4Pe7cxfA6Ystm4BNj31mMYkhGq1KIWWokRvfqDrsMQ_XjdSOm6FmMuPVLiQEEMKUXszDa6jY07w5nZ9zZrs-9t9r3Nofco3R4kHL_65TCaBA49jG0iQjZtcP_p38vQii0</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Williams, Stuart K.</creator><creator>Birla, Ravi K.</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Tissue engineering solutions to replace contractile function during pediatric heart surgery</title><author>Williams, Stuart K. ; Birla, Ravi K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-64a844ba349d3f07cf5fddc404a53f133a968f049a9d4974e24ca7a5289cbcda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Cardiac muscle</topic><topic>Fontan pumps</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Heart transplantation</topic><topic>HLHS</topic><topic>Muscle contraction</topic><topic>Muscles</topic><topic>Pediatric heart surgery</topic><topic>Pediatrics</topic><topic>Single ventricle</topic><topic>Surgery</topic><topic>Tissue engineering</topic><topic>Toolkits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Stuart K.</creatorcontrib><creatorcontrib>Birla, Ravi K.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue & cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Stuart K.</au><au>Birla, Ravi K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue engineering solutions to replace contractile function during pediatric heart surgery</atitle><jtitle>Tissue & cell</jtitle><date>2020-12</date><risdate>2020</risdate><volume>67</volume><spage>101452</spage><epage>101452</epage><pages>101452-101452</pages><artnum>101452</artnum><issn>0040-8166</issn><eissn>1532-3072</eissn><abstract>•Pediatric heart sugery remains challenging.•New tools are needed to tackle this enormous challenge.•Bioengineered heart muscle, ventricles, Fontan pumps and hearts can be used in pediatric heart surgery.•This technology can prove to be game-changer in the field of pediatric heart surgery.
Pediatric heart surgery remains challenging due to the small size of the pediatric heart, the severity of congenital abnormalities and the unique characteristics of each case. New tools and technologies are needed to tackle this enormous challenge. Tissue engineering strategies are focused on fabricating contractile heart muscle, ventricles, Fontan pumps and whole hearts, and a transplantable tissue equivalent has tremendous implications in pediatric heart surgery to provide functional cardiac tissue. This technology will prove to be a game-changer in the field of pediatric heart surgery and provide a novel toolkit for pediatric heart surgeons. This review will provide insight into the potential applications of tissue engineering technologies to replace lost contractile function in pediatric patients with heart abnormalities.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.tice.2020.101452</doi><tpages>1</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Abnormalities Cardiac muscle Fontan pumps Heart Heart surgery Heart transplantation HLHS Muscle contraction Muscles Pediatric heart surgery Pediatrics Single ventricle Surgery Tissue engineering Toolkits |
| title | Tissue engineering solutions to replace contractile function during pediatric heart surgery |
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