Tissue engineering solutions to replace contractile function during pediatric heart surgery

•Pediatric heart sugery remains challenging.•New tools are needed to tackle this enormous challenge.•Bioengineered heart muscle, ventricles, Fontan pumps and hearts can be used in pediatric heart surgery.•This technology can prove to be game-changer in the field of pediatric heart surgery. Pediatric...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tissue & cell 2020-12, Vol.67, p.101452-101452, Article 101452
Hauptverfasser: Williams, Stuart K., Birla, Ravi K.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Pediatric heart sugery remains challenging.•New tools are needed to tackle this enormous challenge.•Bioengineered heart muscle, ventricles, Fontan pumps and hearts can be used in pediatric heart surgery.•This technology can prove to be game-changer in the field of pediatric heart surgery. Pediatric heart surgery remains challenging due to the small size of the pediatric heart, the severity of congenital abnormalities and the unique characteristics of each case. New tools and technologies are needed to tackle this enormous challenge. Tissue engineering strategies are focused on fabricating contractile heart muscle, ventricles, Fontan pumps and whole hearts, and a transplantable tissue equivalent has tremendous implications in pediatric heart surgery to provide functional cardiac tissue. This technology will prove to be a game-changer in the field of pediatric heart surgery and provide a novel toolkit for pediatric heart surgeons. This review will provide insight into the potential applications of tissue engineering technologies to replace lost contractile function in pediatric patients with heart abnormalities.
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2020.101452