Evolution of Novartis’ Small Molecule Screening Deck Design

This article summarizes the evolution of the screening deck at the Novartis Institutes for BioMedical Research (NIBR). Historically, the screening deck was an assembly of all available compounds. In 2015, we designed a first deck to facilitate access to diverse subsets with optimized properties. We...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2020-12, Vol.63 (23), p.14425-14447
Hauptverfasser:	Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Johanna, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren G, Pelliccioli, Anna Paola, Schwarze, Manuel, Shultz, Michael D, Stiefl, Nikolaus, Baeschlin, Daniel K
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Drug Evaluation, Preclinical - methods High-Throughput Screening Assays - methods Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!