Microenvironment‐Sensitive Fluorescent Ligand Binds Ascaris Telomere Antiparallel G‐Quadruplex DNA with Blue‐Shift and Enhanced Emission

The development of small molecules that can selectively target G‐quadruplex (G4) DNAs has drawn considerable attention due to their unique physiological and pathological functions. However, only a few molecules have been found to selectively bind a particular G4 DNA structure. We have developed a fl...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-03, Vol.22 (6), p.1042-1048
Hauptverfasser:	Yu, Quan‐Qi, Gao, Juan‐Juan, Lang, Xue‐Xian, Li, Hong‐Yao, Wang, Ming‐Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	antiparallel G4 DNA Aromatic compounds ASC20 carbazoles Binding Carbazole Carbazoles Cytoplasm Deoxyribonucleic acid DNA DNA structure Fluorescence fluorescent ligands Image enhancement Ligands microenvironment-sensitive Microenvironments Molecular docking phenylboronic acid Pyridines Selectivity Telomeres Titration
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