Integrated In Silico-In Vitro Identification and Optimization of Bone Morphogenic Protein-2 Armpit Epitope as Its Antagonist Binding Site

Bone morphogenic protein-2 (BMP-2) is the most documented member of BMP family and plays a crucial role in bone formation and growth. In this study, we systematically analyze and compare the complex crystal structures and interaction properties of BMP-2 with its cognate receptors BMPR-I/BMPR-II and...

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Veröffentlicht in:	The Protein Journal 2020-12, Vol.39 (6), p.703-710
Hauptverfasser:	Wu, Yanping, Jia, Guanghong, Chi, Haiyan, Jiao, Zhaode, Sun, Yinghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal Anatomy Antigenic determinants Binding Sites Biochemistry Bioorganic Chemistry Bone growth Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - antagonists & inhibitors Bone Morphogenetic Protein 2 - chemistry Bone morphogenetic protein receptor type I Bone morphogenetic protein receptor type II Bone Morphogenetic Protein Receptors, Type I - chemistry Bone Morphogenetic Protein Receptors, Type II - chemistry Bone morphogenetic proteins Carrier Proteins - chemistry Chemistry Chemistry and Materials Science Computer Simulation Crystal structure Crystals Epitopes Epitopes - chemistry Fluorescence Histology Humans Morphology Optimization Organic Chemistry Osteogenesis Peptides Protein binding Proteins Receptor mechanisms Receptors Segments Structural analysis Structure Wrist
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